{"id":"https://openalex.org/W82247670","doi":"https://doi.org/10.1096/fasebj.21.5.a449-d","title":"Overexpression of CuZnSOD or MnSOD protects satellite cells from doxorubicin\u2010induced apoptosis","display_name":"Overexpression of CuZnSOD or MnSOD protects satellite cells from doxorubicin\u2010induced apoptosis","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W82247670","doi":"https://doi.org/10.1096/fasebj.21.5.a449-d","mag":"82247670"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a449-d","doi":"https://doi.org/10.1096/fasebj.21.5.a449-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a449-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087949227","display_name":"Quinlyn A. Soltow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quinlyn Ann Soltow","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021315896","display_name":"Vitor Agnew Lira","orcid":"https://orcid.org/0000-0002-3162-3804","observed_orcids":["https://orcid.org/0000-0002-3162-3804"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitor A. Lira","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057038832","display_name":"Jenna L. Betters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna L. Betters","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037990456","display_name":"Joseph M. McClung","orcid":"https://orcid.org/0000-0002-9789-0454","observed_orcids":["https://orcid.org/0000-0002-9789-0454"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. McClung","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106081674","display_name":"Scott K. Powers","orcid":"https://orcid.org/0000-0003-4545-7605","observed_orcids":["https://orcid.org/0000-0003-4545-7605"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott K. Powers","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000765673","display_name":"Holly Van Remmen","orcid":"https://orcid.org/0000-0003-0883-0642","observed_orcids":["https://orcid.org/0000-0003-0883-0642"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Van Remmen","raw_affiliation_strings":["Department of Cellular and Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020688","display_name":"Arlan G Richardson","orcid":"https://orcid.org/0000-0001-9622-7311","observed_orcids":["https://orcid.org/0000-0001-9622-7311"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlan Richardson","raw_affiliation_strings":["Department of Cellular and Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113674351","display_name":"David S. Criswell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Criswell","raw_affiliation_strings":["Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Physiology and Kinesiology University of Florida P.O. Box 118206 Gainesville FL 32611","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01457107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.10649999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8600000143051147},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7229999899864197},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5720000267028809},{"id":"https://openalex.org/keywords/muscle","display_name":"muscle","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7078677415847778},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6968281865119934},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6852709054946899},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6588729023933411},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6479835510253906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.591170608997345},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5273502469062805},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4846647381782532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45766714215278625},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.43091100454330444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4024606943130493},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.34398365020751953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2869254946708679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2022497057914734},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.050081878900527954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a449-d","doi":"https://doi.org/10.1096/fasebj.21.5.a449-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a449-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991073909","https://openalex.org/W1498107721","https://openalex.org/W2151334606","https://openalex.org/W1543924337","https://openalex.org/W2066649956","https://openalex.org/W4238004994","https://openalex.org/W2118936759","https://openalex.org/W6983541212","https://openalex.org/W1982181214","https://openalex.org/W1972701711"],"abstract_inverted_index":{"PURPOSE:":[0],"Doxorubicin":[1,112],"belongs":[2],"to":[3,34,203],"a":[4,94,114,198],"family":[5],"of":[6,15,38,65,120,169,173,185,200],"anticancer":[7],"drugs":[8],"that":[9],"exert":[10],"cytotoxic":[11,167],"effects":[12,168],"by":[13,197,207],"release":[14],"reactive":[16],"oxygen":[17],"species":[18],"(ROS)":[19],"and":[20,28,108,123,145,183],"triggering":[21],"apoptosis.":[22,205],"Since":[23],"antioxidant":[24,176],"enzymes":[25],"scavenge":[26],"ROS":[27],"defend":[29],"against":[30,50,153,180],"apoptosis,":[31],"we":[32],"sought":[33],"determine":[35],"whether":[36],"overexpression":[37,158,172,184],"catalase,":[39,73],"copper\u2010zinc":[40],"superoxide":[41],"dismutase":[42],"(CuZnSOD),":[43],"or":[44,69,75,99,132,187],"manganese":[45],"SOD":[46],"(MnSOD)":[47],"is":[48],"protective":[49],"doxorubicin\u2010mediated":[51],"cell":[52,57],"death.":[53],"METHODS:":[54],"Primary":[55],"satellite":[56,163],"cultures":[58],"were":[59,78,104,151],"derived":[60],"from":[61,165],"the":[62,147,166,174,188,208],"hindlimb":[63],"muscles":[64],"wild":[66],"type":[67],"(WT)":[68],"transgenic":[70],"mice":[71],"overexpressing":[72,130,149],"CuZnSOD,":[74,178],"MnSOD.":[76,133],"Myoblasts":[77],"cultured":[79,162],"in":[80,117,128,141],"growth":[81],"medium":[82],"(10%":[83],"FBS)":[84],"until":[85],"80%":[86],"confluency,":[87],"then":[88],"replated":[89],"at":[90],"equal":[91],"density.":[92],"Following":[93],"24":[95],"hr":[96],"treatment":[97],"with":[98],"without":[100],"5\u03bcM":[101],"doxorubicin,":[102],"cells":[103,129,144,150,164],"fixed":[105],"for":[106],"DAPI":[107],"TUNEL":[109],"staining.":[110],"RESULTS:":[111],"induced":[113],"60%":[115],"decrease":[116],"nuclear":[118],"number":[119],"WT":[121,143],"cells,":[122],"this":[124,154],"effect":[125],"was":[126,138],"abrogated":[127],"CuZnSOD":[131,148,186],"The":[134],"%TUNEL":[135],"positive":[136],"nuclei":[137],"elevated":[139],"six\u2010fold":[140],"doxorubicin\u2010treated":[142],"only":[146],"protected":[152],"effect.":[155],"CONCLUSIONS:":[156],"Catalase":[157],"did":[159],"not":[160],"protect":[161],"doxorubicin.":[170],"However,":[171],"cytosolic":[175],"enzyme,":[177,190],"protects":[179],"DNA":[181],"fragmentation,":[182],"mitochondrial":[189],"MnSOD,":[191],"enhances":[192],"cellular":[193],"survival":[194],"when":[195],"challenged":[196],"dose":[199],"doxorubicin":[201],"known":[202],"induce":[204],"Funded":[206],"American":[209],"Heart":[210],"Association.":[211]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
