{"id":"https://openalex.org/W822348376","doi":null,"title":"Molecular Genetics of Aggressive Behaviour in Drosophila melanogaster","display_name":"Molecular Genetics of Aggressive Behaviour in Drosophila melanogaster","publication_year":2010,"publication_date":"2010-03-24","ids":{"openalex":"https://openalex.org/W822348376","mag":"822348376"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10103645","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","pdf_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068954530","display_name":"Merav Tauber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Merav Tauber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068954530"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.925000011920929},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8140000104904175},{"id":"https://openalex.org/keywords/frg1","display_name":"FRG1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.7570000290870667},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.4399999976158142},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7998073697090149},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6206308007240295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5119637250900269},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.48981472849845886},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4027988016605377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26629579067230225}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:figshare.com:article/10103645","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","pdf_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/992030","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/992030","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/10224","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/10224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:822348376","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551754","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10103645","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","pdf_url":"https://figshare.com/articles/thesis/Molecular_Genetics_of_Aggressive_Behaviour_in_Drosophila_Melanogaster/10103645","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308774","display_name":"John Simon Guggenheim Memorial Foundation","ror":"https://ror.org/0407tnq23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W822348376.pdf","grobid_xml":"https://content.openalex.org/works/W822348376.grobid-xml"},"referenced_works_count":205,"referenced_works":["https://openalex.org/W106302867","https://openalex.org/W119625346","https://openalex.org/W167322806","https://openalex.org/W235176487","https://openalex.org/W567498258","https://openalex.org/W573601381","https://openalex.org/W578545475","https://openalex.org/W602433794","https://openalex.org/W1481715187","https://openalex.org/W1499500424","https://openalex.org/W1512990238","https://openalex.org/W1518586105","https://openalex.org/W1538509751","https://openalex.org/W1538619854","https://openalex.org/W1545361542","https://openalex.org/W1580370988","https://openalex.org/W1580851598","https://openalex.org/W1654410153","https://openalex.org/W1661083499","https://openalex.org/W1677098962","https://openalex.org/W1683239793","https://openalex.org/W1706564076","https://openalex.org/W1748929018","https://openalex.org/W1883653169","https://openalex.org/W1906137309","https://openalex.org/W1915181823","https://openalex.org/W1919985451","https://openalex.org/W1929552083","https://openalex.org/W1932111342","https://openalex.org/W1960351623","https://openalex.org/W1965828393","https://openalex.org/W1967829443","https://openalex.org/W1970156673","https://openalex.org/W1972702822","https://openalex.org/W1973430508","https://openalex.org/W1974249021","https://openalex.org/W1974704333","https://openalex.org/W1975970936","https://openalex.org/W1977632985","https://openalex.org/W1983752985","https://openalex.org/W1984331786","https://openalex.org/W1985659366","https://openalex.org/W1987381365","https://openalex.org/W1988040684","https://openalex.org/W1990192893","https://openalex.org/W1990425248","https://openalex.org/W1991279445","https://openalex.org/W1991438019","https://openalex.org/W1992599919","https://openalex.org/W1993827187","https://openalex.org/W1994713392","https://openalex.org/W1998073743","https://openalex.org/W1999819966","https://openalex.org/W2000805219","https://openalex.org/W2000971209","https://openalex.org/W2001119798","https://openalex.org/W2001219106","https://openalex.org/W2002664886","https://openalex.org/W2004033705","https://openalex.org/W2005121218","https://openalex.org/W2005551476","https://openalex.org/W2006943536","https://openalex.org/W2008183439","https://openalex.org/W2010450338","https://openalex.org/W2010747656","https://openalex.org/W2011435140","https://openalex.org/W2012192129","https://openalex.org/W2014605680","https://openalex.org/W2019511380","https://openalex.org/W2022678484","https://openalex.org/W2027298044","https://openalex.org/W2029441111","https://openalex.org/W2032176996","https://openalex.org/W2032994676","https://openalex.org/W2033322475","https://openalex.org/W2034060877","https://openalex.org/W2034825766","https://openalex.org/W2035004424","https://openalex.org/W2036690337","https://openalex.org/W2037415930","https://openalex.org/W2039295111","https://openalex.org/W2040368827","https://openalex.org/W2042168483","https://openalex.org/W2042191084","https://openalex.org/W2042565883","https://openalex.org/W2043484525","https://openalex.org/W2043659972","https://openalex.org/W2045839099","https://openalex.org/W2046757587","https://openalex.org/W2049376715","https://openalex.org/W2051807775","https://openalex.org/W2053046762","https://openalex.org/W2054516409","https://openalex.org/W2054856840","https://openalex.org/W2055798512","https://openalex.org/W2056213320","https://openalex.org/W2056863404","https://openalex.org/W2060773435","https://openalex.org/W2061541290","https://openalex.org/W2064589942","https://openalex.org/W2064848207","https://openalex.org/W2065923653","https://openalex.org/W2067895067","https://openalex.org/W2067932072","https://openalex.org/W2068609871","https://openalex.org/W2072127205","https://openalex.org/W2072511595","https://openalex.org/W2073036589","https://openalex.org/W2073704510","https://openalex.org/W2075784238","https://openalex.org/W2076475195","https://openalex.org/W2076486861","https://openalex.org/W2077671034","https://openalex.org/W2079030539","https://openalex.org/W2080293960","https://openalex.org/W2080422256","https://openalex.org/W2081697647","https://openalex.org/W2081797842","https://openalex.org/W2082397632","https://openalex.org/W2085465281","https://openalex.org/W2085936836","https://openalex.org/W2086313279","https://openalex.org/W2086653658","https://openalex.org/W2086967162","https://openalex.org/W2088842558","https://openalex.org/W2089049622","https://openalex.org/W2090355988","https://openalex.org/W2091287207","https://openalex.org/W2091942994","https://openalex.org/W2095257990","https://openalex.org/W2095939456","https://openalex.org/W2096071379","https://openalex.org/W2096683144","https://openalex.org/W2098526108","https://openalex.org/W2102791000","https://openalex.org/W2102804765","https://openalex.org/W2103017472","https://openalex.org/W2103080800","https://openalex.org/W2104755990","https://openalex.org/W2105581244","https://openalex.org/W2106417817","https://openalex.org/W2108101655","https://openalex.org/W2108550123","https://openalex.org/W2108762933","https://openalex.org/W2109186630","https://openalex.org/W2109363337","https://openalex.org/W2109851694","https://openalex.org/W2110643873","https://openalex.org/W2111544501","https://openalex.org/W2112808172","https://openalex.org/W2113795405","https://openalex.org/W2114572783","https://openalex.org/W2114773717","https://openalex.org/W2114958179","https://openalex.org/W2117983072","https://openalex.org/W2118629895","https://openalex.org/W2119147856","https://openalex.org/W2121009082","https://openalex.org/W2122244877","https://openalex.org/W2122259408","https://openalex.org/W2124728852","https://openalex.org/W2126084294","https://openalex.org/W2126191582","https://openalex.org/W2127031542","https://openalex.org/W2127938920","https://openalex.org/W2128964111","https://openalex.org/W2129815183","https://openalex.org/W2129950297","https://openalex.org/W2130515385","https://openalex.org/W2132985847","https://openalex.org/W2135563396","https://openalex.org/W2138191706","https://openalex.org/W2138665253","https://openalex.org/W2138814742","https://openalex.org/W2141652419","https://openalex.org/W2143808215","https://openalex.org/W2146575770","https://openalex.org/W2149725110","https://openalex.org/W2150304723","https://openalex.org/W2150972545","https://openalex.org/W2151084829","https://openalex.org/W2151259804","https://openalex.org/W2151299977","https://openalex.org/W2154076545","https://openalex.org/W2157677118","https://openalex.org/W2157688858","https://openalex.org/W2159686532","https://openalex.org/W2160114821","https://openalex.org/W2162719960","https://openalex.org/W2170148961","https://openalex.org/W2171149323","https://openalex.org/W2171520516","https://openalex.org/W2171552038","https://openalex.org/W2171973454","https://openalex.org/W2172058945","https://openalex.org/W2177879874","https://openalex.org/W2238237592","https://openalex.org/W2248229481","https://openalex.org/W2327161361","https://openalex.org/W2476349889","https://openalex.org/W2479502720","https://openalex.org/W2481931426","https://openalex.org/W2501594143","https://openalex.org/W2504532741","https://openalex.org/W2800606011"],"related_works":["https://openalex.org/W2575796877","https://openalex.org/W4292361874","https://openalex.org/W2171149323","https://openalex.org/W1966657413","https://openalex.org/W1877601466","https://openalex.org/W2152234914","https://openalex.org/W2108101655","https://openalex.org/W2587893138","https://openalex.org/W2079320843","https://openalex.org/W3199447476"],"abstract_inverted_index":{"Aggression":[0],"is":[1,27,196,209,246,269],"a":[2,12,31,49,89,242,275],"key":[3],"component":[4],"of":[5,9,15,57,61,74,85,96,99,137,141,161,164,251,266,297],"the":[6,22,55,75,83,94,138,159,165,220,229],"normal":[7],"repertoire":[8],"behaviours":[10],"in":[11,92,176,198,234,261,291],"broad":[13],"range":[14],"animals":[16],"from":[17],"insects":[18],"to":[19,53,65,237],"mammals.":[20],"Although":[21],"genetic":[23],"basis":[24],"for":[25,248],"aggression":[26,70,95,208],"widely":[28],"accepted,":[29],"only":[30,194,206],"few":[32],"individual":[33],"candidate":[34,253],"genes":[35,67,109,143,169],"have":[36,41],"been":[37],"studied.":[38],"Recent":[39],"studies":[40],"indicated":[42],"that":[43,110,149,157,193,204,214,228,241,293],"Drosophila":[44],"melanogaster":[45],"can":[46,215],"serve":[47,151],"as":[48,123,152],"powerful":[50],"model":[51],"system":[52],"study":[54,87],"genetics":[56],"aggression.":[58,298],"The":[59,264],"aim":[60],"this":[62,86,267,286],"project":[63],"was":[64,88,101,170,174,255],"identify":[66],"associated":[68],"with":[69,280],"by":[71,184,218,288],"global":[72],"profiling":[73],"fly":[76],"transcriptome":[77],"using":[78],"DNA":[79],"expression":[80],"microarrays.":[81],"At":[82],"core":[84],"behavioural":[90],"screen":[91],"which":[93,173],"910":[97],"pairs":[98],"males":[100],"observed":[102],"and":[103,116,130,188],"scored.":[104],"Microarray":[105],"analysis":[106,191],"revealed":[107,192],"350":[108],"were":[111,133,259],"differentially":[112,167],"expressed":[113,168],"between":[114,244],"aggressive":[115,177,199,262],"nonaggressive":[117],"flies.":[118,178,200,263],"Several":[119],"biological":[120],"functions":[121],"such":[122],"translation":[124],"activity,":[125],"immune":[126],"response,":[127],"ion":[128],"transport,":[129],"sensory":[131],"transduction":[132],"significantly":[134],"over-represented.":[135],"Analysis":[136],"upstream":[139],"region":[140],"these":[142,162],"also":[144,210],"suggested":[145],"several":[146],"shared":[147],"motifs":[148],"might":[150],"transcription":[153],"factor":[154],"binding":[155],"sites":[156],"drive":[158],"co-expression":[160],"genes.\\nOne":[163],"top":[166],"Dat,":[171],"(dopamine-Nacetyltransferase),":[172],"upregulated":[175,197],"Dat":[179],"has":[180],"two":[181,230],"isoforms":[182,231],"generated":[183],"alternative":[185],"splicing,":[186],"DatA":[187,221],"DatB.":[189],"QPCR":[190],"DatB":[195,226],"In":[201],"Datlo":[202],"mutants":[203],"express":[205],"DatB,":[207],"increased,":[211],"an":[212],"effect":[213],"be":[216],"reverted":[217],"over-expressing":[219,225],"transgene.":[222],"Additional":[223],"experiments":[224],"indicate":[227],"effectively":[232],"act":[233],"opposite":[235],"ways":[236],"regulate":[238],"aggression,":[239],"suggesting":[240],"balance":[243],"them":[245],"necessary":[247],"adaptive":[249],"levels":[250,258,296],"aggression.\\nAnother":[252],"gene":[254,268,287],"CG6480,":[256],"whose":[257],"reduced":[260],"function":[265],"unknown,":[270],"but":[271],"it":[272],"does":[273],"share":[274],"conserved":[276],"motif":[277],"called":[278],"Fascin":[279],"its":[281],"mammalian":[282],"ortholog":[283],"frg1.":[284],"Silencing":[285],"dsRNAi":[289],"resulted":[290],"flies":[292],"show":[294],"elevated":[295]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
