{"id":"https://openalex.org/W82234544","doi":null,"title":"Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration.","display_name":"Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W82234544","mag":"82234544","pmid":"https://pubmed.ncbi.nlm.nih.gov/25197371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152061"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3124746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"parent_works":[],"lineage":["https://openalex.org/W82234544"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152061","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082029558","display_name":"Changshun Huang","orcid":"https://orcid.org/0000-0003-4385-042X","observed_orcids":["https://orcid.org/0000-0003-4385-042X"]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changshun Huang","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xingcai Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingcai Zhang","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082204269","display_name":"Jungang Zheng","orcid":"https://orcid.org/0000-0003-0932-2287","observed_orcids":["https://orcid.org/0000-0003-0932-2287"]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jungang Zheng","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071629790","display_name":"Chunru Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunru Chen","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yijun Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijun Chen","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015781504","display_name":"Juan Yi","orcid":"https://orcid.org/0000-0002-1718-1528","observed_orcids":["https://orcid.org/0000-0002-1718-1528"]},"institutions":[{"id":"https://openalex.org/I4210166261","display_name":"Ningbo First Hospital","ror":"https://ror.org/05pkzpg75","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Yi","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Ningbo City 59 Liuting St., Ningbo 315010, Zhejiang, China","institution_ids":["https://openalex.org/I4210166261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210166261"],"apc_list":null,"apc_paid":null,"fwci":0.8799,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.63811563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"8","first_page":"5000","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-137","display_name":"miR-137","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.828000009059906},{"id":"https://openalex.org/keywords/anesthetic-neurotoxicity","display_name":"anesthetic neurotoxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hippocampal-neurodegeneration","display_name":"hippocampal neurodegeneration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.7789999842643738},{"id":"https://openalex.org/keywords/newborn-brain","display_name":"neonatal brain","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.9007977247238159},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8911424875259399},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7878027558326721},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.6301067471504211},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.5626266598701477},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5475814938545227},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47411397099494934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.406316876411438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3080774247646332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1802869737148285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000778","descriptor_name":"Anesthetics, Dissociative","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3124746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25197371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25197371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4152061","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4152061/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:82234544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25197371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3124746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W182314314","https://openalex.org/W1965174866","https://openalex.org/W1965256565","https://openalex.org/W1967253824","https://openalex.org/W1984454826","https://openalex.org/W1987497534","https://openalex.org/W2007759608","https://openalex.org/W2012982950","https://openalex.org/W2021099633","https://openalex.org/W2022847903","https://openalex.org/W2025902983","https://openalex.org/W2027873044","https://openalex.org/W2041458184","https://openalex.org/W2044209269","https://openalex.org/W2055103272","https://openalex.org/W2064355745","https://openalex.org/W2069897173","https://openalex.org/W2072117239","https://openalex.org/W2080998660","https://openalex.org/W2119434714","https://openalex.org/W2126248183","https://openalex.org/W2138473891"],"related_works":["https://openalex.org/W2099930837","https://openalex.org/W1561132674","https://openalex.org/W4413803982","https://openalex.org/W1990271819","https://openalex.org/W2328645970","https://openalex.org/W4206855704","https://openalex.org/W1994675075","https://openalex.org/W2778421944","https://openalex.org/W2896115992","https://openalex.org/W2902018955"],"abstract_inverted_index":{"PURPOSE:":[0],"Ketamine":[1],"is":[2,20],"commonly":[3],"used":[4,60],"in":[5,12,34,37,153,156,163,191,224],"pediatric":[6],"anesthesia":[7],"but":[8],"may":[9],"cause":[10],"neurodegeneration":[11,36,65,113,177],"young":[13],"brains.":[14],"The":[15,134,181],"aim":[16],"of":[17,30,66,78,107,124,136,161,172,184,211],"the":[18,28,63,76,88,104,120,209],"study":[19],"to":[21,26,61,74,86,208],"use":[22],"an":[23,198,221],"animal":[24],"model":[25],"characterize":[27],"role":[29,223],"microRNA":[31],"137":[32],"(miR-137)":[33],"ketamine-induced":[35,64,111],"neonatal":[38],"hippocampus.":[39,133,192],"METHODS:":[40],"Young":[41],"Sprague-Dawley":[42],"Rats":[43],"(1":[44],"month":[45],"old)":[46],"was":[47,59,96,127,187],"systemically":[48],"administrated":[49],"with":[50],"ketamine":[51,101,150,190,212,226],"(75":[52],"mg/kg)":[53],"for":[54],"3":[55],"days.":[56],"TUNEL":[57],"assay":[58],"assess":[62,75,87],"hippocampal":[67,112,140,157,176,195,202,228],"CA1":[68,158],"neurons,":[69,159],"quantitative":[70],"real-time":[71],"PCR":[72],"(qRT-PCR)":[73],"expression":[77],"miR-137":[79,95,108,162,174,219],"and":[80,103,114,142,165,178,204],"Morris":[81],"water":[82],"maze":[83],"test":[84],"(MWM)":[85],"damaged":[89],"memory":[90,115,143,168,179,205],"function.":[91],"Alternatively,":[92],"lentivirus":[93],"over-expressing":[94],"injected":[97],"into":[98,132],"hippocampus":[99,164],"before":[100],"administration,":[102],"subsequent":[105],"effects":[106,135],"upregulation":[109],"on":[110,139,201],"dysfunction":[116],"were":[117,145],"investigated.":[118,147],"Furthermore,":[119],"direct":[121],"downstream":[122],"target":[123,183],"miR-137,":[125,185],"CDC42,":[126],"down-regulated":[128,188],"by":[129,189],"siRNA":[130],"injection":[131],"CDC42":[137,186,196],"inhibition":[138],"apoptosis":[141,155],"function":[144],"also":[146],"RESULTS:":[148],"Excessive":[149],"treatment":[151],"resulted":[152],"severe":[154],"downregulation":[160],"significant":[166],"long-term":[167],"dysfunction.":[169],"Conversely,":[170],"pre-treatment":[171],"overexpressing":[173],"protected":[175],"loss.":[180],"molecular":[182],"Knocking":[193],"down":[194],"exerted":[197],"apoptotic":[199],"effect":[200,210],"neurons":[203],"loss,":[206],"similar":[207],"treatment.":[213],"CONCLUSIONS:":[214],"Our":[215],"results":[216],"demonstrated":[217],"that":[218],"played":[220],"important":[222],"regulating":[225],"induced":[227],"neurodegeneration,":[229],"possibly":[230],"through":[231],"CDC42.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
