{"id":"https://openalex.org/W821377020","doi":null,"title":"Investigating the role of zoledronate for inhibition of osteosarcoma metastasis","display_name":"Investigating the role of zoledronate for inhibition of osteosarcoma metastasis","publication_year":2013,"publication_date":"2013-05-24","ids":{"openalex":"https://openalex.org/W821377020","mag":"821377020"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/44230","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/44230","pdf_url":"https://www.ideals.illinois.edu/items/44203/bitstreams/131589/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/44203/bitstreams/131589/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087086666","display_name":"Sharon Shor","orcid":"https://orcid.org/0000-0002-1348-4409","observed_orcids":["https://orcid.org/0000-0002-1348-4409"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Shor","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1348-4409","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087086666"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.949999988079071},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/canine-osteosarcoma","display_name":"canine osteosarcoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.8029999732971191},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-prenylation","display_name":"protein prenylation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.628000020980835},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/myosin-light-chain-2-phosphorylation","display_name":"myosin light chain 2 phosphorylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/k7m2-cells","display_name":"K7M2 cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/antiresorptive-agents","display_name":"antiresorptive agents","score":0.6819999814033508},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.5950000286102295},{"id":"https://openalex.org/keywords/rocks","display_name":"rocks","score":0.3569999933242798},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8164865970611572},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5825896263122559},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4630349576473236},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3960127532482147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35110747814178467},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.327648788690567},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32532310485839844}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/44230","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/44230","pdf_url":"https://www.ideals.illinois.edu/items/44203/bitstreams/131589/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:821377020","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/44230","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/44230","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/44230","pdf_url":"https://www.ideals.illinois.edu/items/44203/bitstreams/131589/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W821377020.pdf","grobid_xml":"https://content.openalex.org/works/W821377020.grobid-xml"},"referenced_works_count":272,"referenced_works":["https://openalex.org/W19745091","https://openalex.org/W55737305","https://openalex.org/W73980168","https://openalex.org/W81352928","https://openalex.org/W92784205","https://openalex.org/W94352984","https://openalex.org/W202362946","https://openalex.org/W343881469","https://openalex.org/W1480706413","https://openalex.org/W1484020898","https://openalex.org/W1495945591","https://openalex.org/W1496786144","https://openalex.org/W1506680628","https://openalex.org/W1508695192","https://openalex.org/W1520425169","https://openalex.org/W1524250143","https://openalex.org/W1532955823","https://openalex.org/W1537459781","https://openalex.org/W1544783284","https://openalex.org/W1553861239","https://openalex.org/W1565417674","https://openalex.org/W1576773659","https://openalex.org/W1587396798","https://openalex.org/W1601070508","https://openalex.org/W1744990552","https://openalex.org/W1763354322","https://openalex.org/W1782000195","https://openalex.org/W1828512827","https://openalex.org/W1910650341","https://openalex.org/W1917160644","https://openalex.org/W1938796902","https://openalex.org/W1963780296","https://openalex.org/W1964081206","https://openalex.org/W1964145620","https://openalex.org/W1964579181","https://openalex.org/W1964770292","https://openalex.org/W1964816418","https://openalex.org/W1965511198","https://openalex.org/W1967265143","https://openalex.org/W1967304777","https://openalex.org/W1969909442","https://openalex.org/W1970523400","https://openalex.org/W1971303929","https://openalex.org/W1975020953","https://openalex.org/W1975044092","https://openalex.org/W1975178229","https://openalex.org/W1975805439","https://openalex.org/W1976686277","https://openalex.org/W1976764541","https://openalex.org/W1976768672","https://openalex.org/W1977202592","https://openalex.org/W1977381126","https://openalex.org/W1978478799","https://openalex.org/W1979684922","https://openalex.org/W1979687059","https://openalex.org/W1979988883","https://openalex.org/W1980525108","https://openalex.org/W1980755015","https://openalex.org/W1981840508","https://openalex.org/W1985617800","https://openalex.org/W1985727076","https://openalex.org/W1986402843","https://openalex.org/W1986471913","https://openalex.org/W1987341205","https://openalex.org/W1987660792","https://openalex.org/W1987966101","https://openalex.org/W1988006764","https://openalex.org/W1988957044","https://openalex.org/W1991973226","https://openalex.org/W1992101294","https://openalex.org/W1993216157","https://openalex.org/W1994599132","https://openalex.org/W1994915831","https://openalex.org/W1996937427","https://openalex.org/W1996939951","https://openalex.org/W1997087774","https://openalex.org/W1998811052","https://openalex.org/W2000217512","https://openalex.org/W2003519013","https://openalex.org/W2003692790","https://openalex.org/W2003911004","https://openalex.org/W2004280628","https://openalex.org/W2007785530","https://openalex.org/W2007897263","https://openalex.org/W2008261978","https://openalex.org/W2009096543","https://openalex.org/W2009173930","https://openalex.org/W2009662773","https://openalex.org/W2009718333","https://openalex.org/W2009886857","https://openalex.org/W2012635077","https://openalex.org/W2013571231","https://openalex.org/W2013741646","https://openalex.org/W2015632282","https://openalex.org/W2016884409","https://openalex.org/W2017341363","https://openalex.org/W2019731805","https://openalex.org/W2021437057","https://openalex.org/W2022233074","https://openalex.org/W2022827874","https://openalex.org/W2023046316","https://openalex.org/W2024281238","https://openalex.org/W2024306318","https://openalex.org/W2027810531","https://openalex.org/W2028691987","https://openalex.org/W2029033872","https://openalex.org/W2031276908","https://openalex.org/W2031379405","https://openalex.org/W2031650256","https://openalex.org/W2032100189","https://openalex.org/W2032295238","https://openalex.org/W2032373323","https://openalex.org/W2032840365","https://openalex.org/W2033364737","https://openalex.org/W2033619275","https://openalex.org/W2033677082","https://openalex.org/W2033862150","https://openalex.org/W2034269086","https://openalex.org/W2034550273","https://openalex.org/W2037489902","https://openalex.org/W2042965279","https://openalex.org/W2043201642","https://openalex.org/W2043305034","https://openalex.org/W2043720960","https://openalex.org/W2044868069","https://openalex.org/W2045477445","https://openalex.org/W2045785625","https://openalex.org/W2046613720","https://openalex.org/W2046867705","https://openalex.org/W2046972425","https://openalex.org/W2048082956","https://openalex.org/W2048209624","https://openalex.org/W2048748629","https://openalex.org/W2050108686","https://openalex.org/W2050750704","https://openalex.org/W2050833923","https://openalex.org/W2055007848","https://openalex.org/W2055130200","https://openalex.org/W2055324845","https://openalex.org/W2055870169","https://openalex.org/W2058761715","https://openalex.org/W2059481840","https://openalex.org/W2060205349","https://openalex.org/W2061295375","https://openalex.org/W2062149110","https://openalex.org/W2062406805","https://openalex.org/W2063220206","https://openalex.org/W2065716393","https://openalex.org/W2066801055","https://openalex.org/W2068092779","https://openalex.org/W2068320944","https://openalex.org/W2068490038","https://openalex.org/W2069741520","https://openalex.org/W2069907874","https://openalex.org/W2071199281","https://openalex.org/W2071673129","https://openalex.org/W2072103796","https://openalex.org/W2072400772","https://openalex.org/W2072703569","https://openalex.org/W2076583198","https://openalex.org/W2077080652","https://openalex.org/W2077504823","https://openalex.org/W2077810031","https://openalex.org/W2078878537","https://openalex.org/W2078929995","https://openalex.org/W2080064317","https://openalex.org/W2081015231","https://openalex.org/W2082103058","https://openalex.org/W2083451010","https://openalex.org/W2083487959","https://openalex.org/W2083543572","https://openalex.org/W2084651782","https://openalex.org/W2086641174","https://openalex.org/W2087879911","https://openalex.org/W2089191507","https://openalex.org/W2089607442","https://openalex.org/W2092310663","https://openalex.org/W2092326243","https://openalex.org/W2092868756","https://openalex.org/W2093164779","https://openalex.org/W2093986345","https://openalex.org/W2094864890","https://openalex.org/W2095938297","https://openalex.org/W2096674608","https://openalex.org/W2096791952","https://openalex.org/W2097139356","https://openalex.org/W2097767970","https://openalex.org/W2098916060","https://openalex.org/W2100592123","https://openalex.org/W2101522258","https://openalex.org/W2102085111","https://openalex.org/W2103230017","https://openalex.org/W2104298626","https://openalex.org/W2105503408","https://openalex.org/W2107396952","https://openalex.org/W2108296770","https://openalex.org/W2108627173","https://openalex.org/W2109108548","https://openalex.org/W2109110119","https://openalex.org/W2110144091","https://openalex.org/W2113294064","https://openalex.org/W2114286114","https://openalex.org/W2115436106","https://openalex.org/W2115616972","https://openalex.org/W2115819535","https://openalex.org/W2122513656","https://openalex.org/W2123171945","https://openalex.org/W2123573124","https://openalex.org/W2124166505","https://openalex.org/W2124172558","https://openalex.org/W2125963316","https://openalex.org/W2126496496","https://openalex.org/W2127107445","https://openalex.org/W2127383719","https://openalex.org/W2127999360","https://openalex.org/W2128576963","https://openalex.org/W2128985829","https://openalex.org/W2129926378","https://openalex.org/W2130773646","https://openalex.org/W2131170195","https://openalex.org/W2132678065","https://openalex.org/W2133228804","https://openalex.org/W2135035591","https://openalex.org/W2135105302","https://openalex.org/W2136465920","https://openalex.org/W2137022580","https://openalex.org/W2137035181","https://openalex.org/W2137055217","https://openalex.org/W2138941583","https://openalex.org/W2141570734","https://openalex.org/W2142083272","https://openalex.org/W2142421083","https://openalex.org/W2143092252","https://openalex.org/W2143293161","https://openalex.org/W2144744111","https://openalex.org/W2144860907","https://openalex.org/W2145139438","https://openalex.org/W2146473598","https://openalex.org/W2146678830","https://openalex.org/W2147887967","https://openalex.org/W2151561513","https://openalex.org/W2151881633","https://openalex.org/W2152002380","https://openalex.org/W2152409486","https://openalex.org/W2154589460","https://openalex.org/W2155390148","https://openalex.org/W2155884272","https://openalex.org/W2156323704","https://openalex.org/W2158122368","https://openalex.org/W2158132138","https://openalex.org/W2158362968","https://openalex.org/W2159695799","https://openalex.org/W2160450758","https://openalex.org/W2161182938","https://openalex.org/W2162049443","https://openalex.org/W2163552793","https://openalex.org/W2163563958","https://openalex.org/W2166791066","https://openalex.org/W2167956058","https://openalex.org/W2168128490","https://openalex.org/W2169917705","https://openalex.org/W2169964349","https://openalex.org/W2170447931","https://openalex.org/W2172114097","https://openalex.org/W2176744910","https://openalex.org/W2185247220","https://openalex.org/W2198370968","https://openalex.org/W2255521589","https://openalex.org/W2306096949","https://openalex.org/W2375169070","https://openalex.org/W2398244218","https://openalex.org/W2477644717"],"related_works":["https://openalex.org/W2411914258","https://openalex.org/W2566072857","https://openalex.org/W2263512295","https://openalex.org/W2093986345","https://openalex.org/W1988957044","https://openalex.org/W2170447931","https://openalex.org/W4309368991","https://openalex.org/W4253852303","https://openalex.org/W3035774623","https://openalex.org/W2137055217"],"abstract_inverted_index":{"Osteosarcoma":[0],"(OS)":[1],"is":[2,55,128,162,197],"the":[3,26,35,47,67,71,123,170,193,215,268,279,370,377,443],"most":[4],"common":[5],"primary":[6],"bone":[7,217],"tumor":[8,83,218,232,434],"in":[9,118,178,273,301,340,387,414,436,479],"dogs":[10,480],"and":[11,42,51,88,107,109,157,172,262,271,276,304,308,330,333,339,382,385,427,451,462],"it":[12],"accounts":[13],"for":[14,29,86,152,199,245,282,471,475],"nearly":[15],"10%":[16],"of":[17,37,73,82,125,135,174,206,267,289,350,365,374,379,416,433,446],"all":[18],"diagnosed":[19],"canine":[20,30],"cancers.":[21],"Despite":[22,228],"aggressive":[23],"multimodality":[24],"therapy,":[25],"mortality":[27],"rate":[28,50],"OS":[31,274,294,419,455],"exceeds":[32],"90%":[33],"from":[34,418,439],"development":[36,72,336],"distant":[38,74],"metastases":[39,335,463],"to":[40,59,237,250,356],"lungs":[41],"other":[43],"visceral":[44,239],"organs.":[45],"Given":[46,114],"high":[48],"metastatic":[49],"associated":[52],"mortality,":[53],"there":[54],"a":[56,130,147,163,203,241,411,468],"compelling":[57],"rationale":[58],"explore":[60],"novel":[61],"therapeutic":[62],"approaches":[63],"that":[64,167,255,354,398],"may":[65],"slow":[66],"progression":[68],"or":[69],"inhibit":[70],"metastases.":[75],"Successful":[76],"metastasis":[77,346],"requires":[78,94],"cytoskeletal":[79,96,320,457],"morphogenic":[80],"changes":[81],"cells,":[84,275],"allowing":[85],"efficient":[87],"directional":[89,119],"cell":[90,120,269,389,394,456],"migration.":[91,390],"Cell":[92],"motility":[93,272],"coordinated":[95],"rearrangement":[97],"largely":[98],"controlled":[99],"by":[100,142,191,298,315,328],"Rho":[101,126,136,153,259,306,360,367,449],"GTPase":[102,137,154,260],"proteins":[103],"(RhoA,":[104],"RhoC,":[105],"Rac-1":[106],"Cdc42)":[108],"effector":[110],"pathways":[111],"(Rho-kinase;":[112],"ROCK).":[113],"their":[115,452],"pivotal":[116,148],"role":[117],"migration,":[121,459],"perturbing":[122],"function":[124],"GTPases":[127,307,361,368,450],"considered":[129],"viable":[131],"anti-metastasis":[132],"strategy.":[133],"Disruption":[134],"functions":[138],"can":[139,400],"be":[140,251],"achieved":[141,429],"interfering":[143],"with":[144,264,322,362,431,481],"protein":[145,200],"prenylation,":[146],"post-translational":[149],"modification":[150],"necessary":[151,198],"subcellular":[155],"localization":[156],"protein-protein":[158],"interactions.":[159],"Zoledronate":[160],"(ZOL)":[161],"potent":[164],"antiresorptive":[165,182],"agent":[166],"definitively":[168],"reduces":[169],"frequency":[171],"severity":[173],"malignant":[175],"skeletal":[176],"complications":[177],"people.":[179],"As":[180],"an":[181,343],"agent,":[183],"ZOL":[184,256,290,357,399,408,447,474],"exerts":[185],"its":[186,211],"biologic":[187],"effects":[188,213,288,445],"on":[189,291,448,454],"osteoclasts":[190],"inhibiting":[192],"mevalonate":[194],"pathway":[195],"which":[196],"prenylation.":[201],"Although":[202],"large":[204],"body":[205],"scientific":[207],"information":[208],"exists":[209],"characterizing":[210,299],"anticancer":[212],"within":[214,369],"local":[216],"microenvironment,":[219],"ZOL\u2019s":[220,235,283],"potential":[221],"antimetastatic":[222,285],"properties":[223],"remain":[224],"less":[225],"well":[226],"defined.":[227],"several":[229],"different":[230],"murine":[231,293],"models":[233],"describing":[234],"capacity":[236],"reduce":[238],"metastases,":[240],"unifying":[242],"molecular":[243,280],"mechanism":[244],"these":[246],"observations":[247,466],"has":[248],"yet":[249],"reported.":[252],"We":[253],"hypothesized":[254],"will":[257],"impair":[258],"prenylation":[261],"activity,":[263],"subsequent":[265],"perturbation":[266],"cytoskeleton":[270],"serve":[277],"as":[278],"basis":[281,470],"observed":[284],"effects.":[286],"The":[287,348],"K7M2":[292],"cells":[295,435],"were":[296,353],"investigated":[297],"perturbations":[300],"1)":[302],"membrane":[303],"cytosolic":[305],"phosphorylated":[309],"myosin":[310],"light":[311],"chain":[312],"2":[313],"(p-MLC2)":[314],"western":[316],"blot":[317],"analysis;":[318],"2)":[319],"structure":[321],"confocal":[323],"fluorescence":[324],"microscopy;":[325],"3)":[326],"migration":[327],"qualitative":[329],"quantitative":[331],"analyses;":[332],"4)":[334],"ex":[337],"vivo":[338,341,392],"using":[342],"experimental":[344],"lung":[345,420],"model.":[347],"results":[349],"this":[351,423,440],"study":[352],"exposure":[355],"decreased":[358],"membrane-bound":[359],"concurrent":[363],"accumulation":[364],"unprenylated":[366],"cytosol,":[371],"reduced":[372],"expression":[373,378],"p-MLC2,":[375],"attenuated":[376],"focal":[380],"adhesions":[381],"filamentous":[383],"actin,":[384],"inhibited":[386],"vitro":[388],"Ex":[391],"single":[393],"videomicroscopy":[395],"also":[396],"showed":[397],"significantly":[401],"decrease":[402],"early":[403],"pulmonary":[404],"nodule":[405],"formation.":[406,464],"Lastly,":[407],"treatment":[409],"induced":[410],"significant":[412],"increase":[413],"survival":[415],"mice":[417],"nodules;":[421],"however,":[422],"improvement":[424],"was":[425,428],"modest":[426],"only":[430],"pre-treatment":[432],"vitro.":[437],"Findings":[438],"investigation":[441],"document":[442],"prenylation-dependent":[444],"impact":[453],"organization,":[458],"survival,":[460],"proliferation,":[461],"These":[465],"provide":[467],"foundational":[469],"evaluating":[472],"adjuvant":[473],"managing":[476],"micrometastatic":[477],"disease":[478],"spontaneously-arising":[482],"OS.":[483]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
