{"id":"https://openalex.org/W821372144","doi":null,"title":"MicroRNAs play a role in human embryonic stem cell differentiation into endothelial cells","display_name":"MicroRNAs play a role in human embryonic stem cell differentiation into endothelial cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W821372144","mag":"821372144"},"language":"en","primary_location":{"id":"pmh:hdl:10068/988913","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/988913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/988913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111027529","display_name":"Zhenling Luo","orcid":"https://orcid.org/0009-0008-3224-2158","observed_orcids":["https://orcid.org/0009-0008-3224-2158"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhenling Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111027529"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endothelial-cell-differentiation","display_name":"endothelial differentiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mir-150","display_name":"miR-150","score":0.824999988079071},{"id":"https://openalex.org/keywords/mir-200c","display_name":"miR-200c","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vascular-development","display_name":"vascular development","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cardiovascular-disease-treatment","display_name":"cardiovascular disease treatment","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8208421468734741},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6960793733596802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6766927242279053},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6020218133926392},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5707926154136658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5405595898628235},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4372745454311371},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20748528838157654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08092251420021057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06520149111747742}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/988913","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/988913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/2425","doi":null,"is_oa":false,"landing_page_url":"http://qmro.qmul.ac.uk/jspui/handle/123456789/2425","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:821372144","doi":null,"is_oa":false,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/bitstream/handle/123456789/2425/LUOMicroRNAs2011.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/988913","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/988913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":224,"referenced_works":["https://openalex.org/W6447436","https://openalex.org/W82495485","https://openalex.org/W1235263458","https://openalex.org/W1512987131","https://openalex.org/W1534692597","https://openalex.org/W1568769949","https://openalex.org/W1576487484","https://openalex.org/W1669562987","https://openalex.org/W1679229092","https://openalex.org/W1754416883","https://openalex.org/W1772272803","https://openalex.org/W1786702086","https://openalex.org/W1833499979","https://openalex.org/W1845717996","https://openalex.org/W1858856929","https://openalex.org/W1912592877","https://openalex.org/W1920303762","https://openalex.org/W1945199177","https://openalex.org/W1948275303","https://openalex.org/W1968102833","https://openalex.org/W1968904691","https://openalex.org/W1973876456","https://openalex.org/W1974175370","https://openalex.org/W1974595624","https://openalex.org/W1976799970","https://openalex.org/W1977120253","https://openalex.org/W1978785103","https://openalex.org/W1978927205","https://openalex.org/W1979356105","https://openalex.org/W1980247655","https://openalex.org/W1980269624","https://openalex.org/W1981494523","https://openalex.org/W1983312218","https://openalex.org/W1984948945","https://openalex.org/W1985014243","https://openalex.org/W1985658116","https://openalex.org/W1985822484","https://openalex.org/W1986903527","https://openalex.org/W1988376520","https://openalex.org/W1988774439","https://openalex.org/W1989436447","https://openalex.org/W1989910375","https://openalex.org/W1990809270","https://openalex.org/W1992389076","https://openalex.org/W1992838550","https://openalex.org/W1992941735","https://openalex.org/W1993000387","https://openalex.org/W1993799748","https://openalex.org/W1994091018","https://openalex.org/W1994993971","https://openalex.org/W1996630410","https://openalex.org/W1997303582","https://openalex.org/W2000453258","https://openalex.org/W2002179012","https://openalex.org/W2002768599","https://openalex.org/W2003207389","https://openalex.org/W2003240618","https://openalex.org/W2004472590","https://openalex.org/W2004791359","https://openalex.org/W2005226383","https://openalex.org/W2013029756","https://openalex.org/W2013297672","https://openalex.org/W2015648732","https://openalex.org/W2016112105","https://openalex.org/W2018989038","https://openalex.org/W2021638217","https://openalex.org/W2023893373","https://openalex.org/W2024704386","https://openalex.org/W2025635382","https://openalex.org/W2026581189","https://openalex.org/W2027199538","https://openalex.org/W2028997661","https://openalex.org/W2029926319","https://openalex.org/W2030727919","https://openalex.org/W2031955280","https://openalex.org/W2032766715","https://openalex.org/W2037531859","https://openalex.org/W2039551265","https://openalex.org/W2041231786","https://openalex.org/W2042673698","https://openalex.org/W2043080209","https://openalex.org/W2044586762","https://openalex.org/W2044880526","https://openalex.org/W2045148822","https://openalex.org/W2045899482","https://openalex.org/W2047015004","https://openalex.org/W2047767613","https://openalex.org/W2048321002","https://openalex.org/W2049760106","https://openalex.org/W2050637668","https://openalex.org/W2050869737","https://openalex.org/W2051430335","https://openalex.org/W2052210687","https://openalex.org/W2053490054","https://openalex.org/W2053911973","https://openalex.org/W2054109341","https://openalex.org/W2054498037","https://openalex.org/W2054521968","https://openalex.org/W2055755227","https://openalex.org/W2055833846","https://openalex.org/W2056238624","https://openalex.org/W2056396000","https://openalex.org/W2056401732","https://openalex.org/W2057159461","https://openalex.org/W2058398135","https://openalex.org/W2059357290","https://openalex.org/W2059382687","https://openalex.org/W2060515109","https://openalex.org/W2061023704","https://openalex.org/W2061997335","https://openalex.org/W2064225457","https://openalex.org/W2065561108","https://openalex.org/W2065596014","https://openalex.org/W2067161271","https://openalex.org/W2069344563","https://openalex.org/W2070451931","https://openalex.org/W2071596792","https://openalex.org/W2072155079","https://openalex.org/W2072990456","https://openalex.org/W2073759231","https://openalex.org/W2074466423","https://openalex.org/W2075122609","https://openalex.org/W2077639718","https://openalex.org/W2079075601","https://openalex.org/W2080680505","https://openalex.org/W2080696342","https://openalex.org/W2081825152","https://openalex.org/W2082213106","https://openalex.org/W2082332064","https://openalex.org/W2083381199","https://openalex.org/W2084040722","https://openalex.org/W2084201375","https://openalex.org/W2085874686","https://openalex.org/W2085931182","https://openalex.org/W2086851461","https://openalex.org/W2086914779","https://openalex.org/W2086943348","https://openalex.org/W2088468623","https://openalex.org/W2089129295","https://openalex.org/W2090465622","https://openalex.org/W2092113020","https://openalex.org/W2092647929","https://openalex.org/W2093540365","https://openalex.org/W2094320086","https://openalex.org/W2095022753","https://openalex.org/W2095828707","https://openalex.org/W2095998404","https://openalex.org/W2098400443","https://openalex.org/W2099517697","https://openalex.org/W2100358595","https://openalex.org/W2102209691","https://openalex.org/W2104978512","https://openalex.org/W2108287070","https://openalex.org/W2110319330","https://openalex.org/W2111783800","https://openalex.org/W2112436512","https://openalex.org/W2116799486","https://openalex.org/W2118278618","https://openalex.org/W2119897756","https://openalex.org/W2121390857","https://openalex.org/W2121455258","https://openalex.org/W2121822802","https://openalex.org/W2122661176","https://openalex.org/W2123079914","https://openalex.org/W2123938685","https://openalex.org/W2124268899","https://openalex.org/W2125987139","https://openalex.org/W2127131367","https://openalex.org/W2127432537","https://openalex.org/W2127664505","https://openalex.org/W2129994868","https://openalex.org/W2130154562","https://openalex.org/W2130975786","https://openalex.org/W2131722060","https://openalex.org/W2133613849","https://openalex.org/W2138442302","https://openalex.org/W2138664009","https://openalex.org/W2138977668","https://openalex.org/W2139961479","https://openalex.org/W2141126811","https://openalex.org/W2143640595","https://openalex.org/W2145091080","https://openalex.org/W2145539666","https://openalex.org/W2145790583","https://openalex.org/W2146042550","https://openalex.org/W2147173836","https://openalex.org/W2147807172","https://openalex.org/W2148069495","https://openalex.org/W2149146453","https://openalex.org/W2149291473","https://openalex.org/W2149785901","https://openalex.org/W2149930662","https://openalex.org/W2150197150","https://openalex.org/W2150907607","https://openalex.org/W2151515540","https://openalex.org/W2151922790","https://openalex.org/W2152899507","https://openalex.org/W2153401001","https://openalex.org/W2154228322","https://openalex.org/W2154503536","https://openalex.org/W2155227864","https://openalex.org/W2155783606","https://openalex.org/W2155801275","https://openalex.org/W2156629568","https://openalex.org/W2157645703","https://openalex.org/W2158343596","https://openalex.org/W2162855805","https://openalex.org/W2163230397","https://openalex.org/W2163294226","https://openalex.org/W2165786885","https://openalex.org/W2167557255","https://openalex.org/W2168230240","https://openalex.org/W2169098504","https://openalex.org/W2169139173","https://openalex.org/W2170636620","https://openalex.org/W2239897670","https://openalex.org/W2299338986","https://openalex.org/W2320350354","https://openalex.org/W2339411017","https://openalex.org/W2409075727","https://openalex.org/W2416232721","https://openalex.org/W2464414418","https://openalex.org/W2506936785","https://openalex.org/W3113686812"],"related_works":["https://openalex.org/W1563575450","https://openalex.org/W2006440398","https://openalex.org/W2138594245","https://openalex.org/W2236950052","https://openalex.org/W2072839209","https://openalex.org/W7096912151","https://openalex.org/W2077313690","https://openalex.org/W2620274461","https://openalex.org/W2032783135","https://openalex.org/W2060372899"],"abstract_inverted_index":{"The":[0],"past":[1],"recent":[2],"years":[3],"have":[4],"seen":[5],"a":[6,17],"surge":[7],"of":[8,13,19,213,228,237,247,253,280],"evidence":[9],"demonstrating":[10],"the":[11,27,42,66,139,211,233,245,251,278],"regulation":[12],"microRNAs":[14],"(miRNAs)":[15],"in":[16,30,39,50,59,69,78,130,144,165,210,214,250,263,296],"myriad":[18],"vascular":[20,267,289],"biology":[21],"events":[22],"such":[23,96,109,178],"as":[24,97,110,189],"cardiogenesis.":[25],"Nevertheless,":[26],"missing":[28],"miRNA-link":[29],"controlling":[31],"pluripotent":[32],"human":[33],"embryonic":[34,131],"stem":[35],"cell":[36],"(hESC)":[37],"fate":[38],"differentiation":[40,62,167,246],"towards":[41],"endothelial":[43,60,83],"lineage":[44,61],"is":[45],"currently":[46],"undiscovered.":[47],"Main":[48],"objectives":[49],"this":[51,264],"project":[52],"are":[53,57],"determining":[54],"which":[55],"miRNAs":[56,128],"involved":[58,129,209],"from":[63,138,168,282],"hESCs":[64,75,224],"and":[65,85,100,112,136,149,159,173,196,205,258,274,291],"further":[67,187],"delineation":[68],"their":[70],"underlying":[71],"mechanisms.":[72],"Firstly,":[73],"undifferentiated":[74],"were":[76,134,207],"cultured":[77],"differentiating":[79,145],"conditions":[80],"to":[81,232,244],"derive":[82],"(ECs)":[84],"smooth":[86],"muscle":[87],"cells":[88,117,261],"(SMCs).":[89],"hESC-derived":[90,103,116],"ECs":[91,281],"express":[92,105],"specific":[93,106],"EC":[94,132,166],"markers":[95,108],"PECAM/CD31,":[98],"eNOS,":[99],"vWF,":[101],"while":[102],"SMCs":[104],"SMC":[107],"SMA":[111],"SMMHC":[113],"II.":[114],"Both":[115],"also":[118,201,242],"displayed":[119],"functional":[120,123],"characteristics":[121],"upon":[122],"analyses.":[124],"Next,":[125],"five":[126],"potential":[127],"development":[133,279],"determined":[135],"selected":[137],"miRNA":[140],"array":[141],"expression":[142,230],"profile":[143],"hESCs.":[146,169],"Using":[147],"loss-":[148],"gain-of-function":[150],"gene":[151],"experiments,":[152],"it":[153,199],"was":[154,186,200],"demonstrated":[155,202],"that":[156,203,222,272],"both":[157,208],"miR-150":[158],"miR-200c":[160,206,229],"played":[161],"an":[162,190,226],"important":[163,191],"role":[164],"However,":[170],"miR-1915,":[171],"141":[172],"205":[174],"did":[175],"not":[176],"display":[177],"functions.":[179],"In":[180],"addition,":[181],"epithelial-to-mesenchymal":[182],"transition":[183],"(EMT)-activator":[184],"ZEB1/TCF8":[185],"identified":[188],"mRNA":[192],"target":[193],"for":[194,287],"miR-150*":[195,204,273],"200c.":[197],"Importantly,":[198],"vasculogenesis":[212],"vivo":[215],"chick":[216],"embryos.":[217],"These":[218,269],"findings":[219,270],"may":[220],"suggest":[221],"during":[223],"differentiation,":[225],"increase":[227],"contribute":[231],"decline":[234],"or":[235,262],"repression":[236],"EMT":[238],"process.":[239],"Meanwhile,":[240],"mir-150*":[241],"contributes":[243],"hESCs,":[248,283],"resulting":[249],"formation":[252,290],"more":[254],"iii":[255],"differentiated,":[256],"senescence":[257],"less":[259],"proliferative":[260],"case,":[265],"mature":[266],"ECs.":[268],"illustrate":[271],"200c":[275],"can":[276],"regulate":[277],"providing":[284],"new":[285],"targets":[286],"modulating":[288],"creating":[292],"novel":[293],"clinical":[294],"therapies":[295],"future":[297],"cardiovascular":[298],"disease":[299],"applications.":[300]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
