{"id":"https://openalex.org/W82051899","doi":null,"title":"Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms.","display_name":"Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W82051899","mag":"82051899","pmid":"https://pubmed.ncbi.nlm.nih.gov/1296767"},"language":"en","primary_location":{"id":"pmid:1296767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1296767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnesium research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110421164","display_name":"Morris Me","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M E Morris","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, Amherst","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110421164"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":null,"apc_paid":null,"fwci":2.1675,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.84072292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"5","issue":"4","first_page":"303","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10530","display_name":"Magnesium Alloys: Properties and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-magnesium","display_name":"cerebrospinal fluid magnesium","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neurological-symptoms","display_name":"neurological symptoms","score":0.7329999804496765},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hyperexcitability","display_name":"hyperexcitability","score":0.8059999942779541},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nmda-receptor-antagonism","display_name":"NMDA receptor antagonism","score":0.7459999918937683},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/magnesium-supplementation","display_name":"magnesium supplementation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/eclampsia","display_name":"eclampsia","score":0.7990000247955322},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.6549999713897705},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.9259534478187561},{"id":"https://openalex.org/C2780880258","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Magnesium deficiency (plants)","level":3,"score":0.7496018409729004},{"id":"https://openalex.org/C2776183862","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Hypomagnesemia","level":3,"score":0.6290258169174194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.578073263168335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5415705442428589},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40547335147857666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3751637637615204},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008275","descriptor_name":"Magnesium Deficiency","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008275","descriptor_name":"Magnesium Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008275","descriptor_name":"Magnesium Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1296767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1296767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnesium research","raw_type":"Journal Article"},{"id":"mag:82051899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1296767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1997955616","https://openalex.org/W2159292046","https://openalex.org/W4385893556","https://openalex.org/W2083081973","https://openalex.org/W2953763901","https://openalex.org/W2313651480","https://openalex.org/W2586435644","https://openalex.org/W1963985530","https://openalex.org/W3012003233","https://openalex.org/W1976326058"],"abstract_inverted_index":{"Magnesium":[0,324],"is":[1,101,118,168],"an":[2,119],"essential":[3],"cofactor":[4],"for":[5,317,364],"many":[6],"enzymatic":[7],"reactions,":[8],"especially":[9],"those":[10],"involved":[11],"in":[12,36,57,62,98,175,180,189,194,221,226,248,253,281,301,321,329,344,352,388],"energy":[13],"metabolism.":[14],"Deficits":[15],"of":[16,32,55,78,89,96,107,128,132,148,156,200,224,279,381,385],"magnesium":[17,33,56,84,97,111,124,133,138,149,157,177,182,192,203,210,215,232,250,264,282,386],"are":[18,134,267,305,375],"prevalent":[19],"due":[20,27,143,288],"to":[21,28,75,144,234,269,289,377],"inadequate":[22],"intake":[23],"or":[24,109],"malabsorption":[25],"and":[26,42,59,68,116,125,167,284,349,354],"the":[29,90,94,126,145,151,172,186,197,222,290,314,330,365,382,389],"renal":[30],"loss":[31],"that":[34,219,266,292],"occurs":[35],"certain":[37],"disease":[38],"states":[39],"(alcoholism,":[40],"diabetes)":[41],"with":[43,83,185,260,369],"drug":[44],"therapy":[45],"(diuretics,":[46],"aminoglycosides,":[47],"cisplatin,":[48],"digoxin,":[49],"cyclosporin,":[50],"amphotericin":[51],"B).":[52],"Protracted":[53],"deficits":[54],"humans":[58],"animals":[60,195],"result":[61],"neurological":[63,286,383],"disturbances,":[64],"including":[65,342],"hyperexcitability,":[66],"convulsions":[67,225],"various":[69],"psychiatric":[70],"symptoms":[71],"ranging":[72],"from":[73],"apathy":[74],"psychosis,":[76],"some":[77],"which":[79,312,332],"can":[80,112,205,333],"be":[81,207,334,359],"reversed":[82],"supplementation,":[85,211],"others":[86],"requiring":[87],"correction":[88],"dysregulation":[91],"mechanism.":[92],"Although":[93],"role":[95],"neuronal":[99,366],"function":[100],"not":[102],"completely":[103],"understood,":[104],"a":[105,235,276],"lowering":[106],"CSF":[108,123,130,159,181,202,231,249,263],"brain":[110,191,371],"induce":[113],"epileptiform":[114,327],"activity":[115,328],"there":[117],"association":[120],"between":[121],"decreased":[122],"development":[127],"seizures.":[129],"concentrations":[131,142,160,183,193,204,233,265,348],"normally":[135,306],"higher":[136],"than":[137,171],"plasma":[139,176,271],"ultrafiltrate":[140],"(diffusible)":[141],"active":[146],"transport":[147],"across":[150],"blood-brain":[152],"barrier.":[153],"Under":[154],"conditions":[155],"deficiency,":[158],"decline,":[161],"although":[162,212],"this":[163],"decline":[164],"lags":[165],"behind":[166],"less":[169],"pronounced":[170],"changes":[173],"observed":[174,188],"concentrations.":[178,245,272],"Decreases":[179],"correlate":[184],"alterations":[187,343],"extracellular":[190],"following":[196,209,258],"dietary":[198],"deprivation":[199],"magnesium.":[201,372],"readily":[206],"repleted":[208],"high":[213],"dose":[214],"therapy,":[216],"such":[217],"as":[218],"used":[220],"treatment":[223,259],"eclampsia,":[227],"will":[228],"only":[229],"increase":[230,378],"very":[236],"limited":[237],"degree":[238],"(approximately":[239],"11-18":[240],"per":[241],"cent)":[242],"above":[243],"physiological":[244,295],"Greater":[246],"increases":[247],"may":[251,357],"occur":[252],"neonates":[254],"since":[255],"neonatal":[256],"swine,":[257],"magnesium,":[261,293],"have":[262],"similar":[268],"their":[270],"There":[273],"has":[274],"been":[275],"recent":[277],"resurgence":[278],"interest":[280],"deficiency":[283,325],"its":[285],"consequences":[287],"finding":[291],"at":[294,360],"concentrations,":[296],"blocks":[297],"N-methyl-D-aspartate":[298],"(NMDA)":[299],"receptors":[300,304],"neurones.":[302],"NMDA":[303,337],"activated":[307],"by":[308,336],"glutamate":[309],"and/or":[310],"aspartate":[311],"represent":[313],"principal":[315],"neurotransmitters":[316],"excitatory":[318],"synaptic":[319],"transmission":[320],"vertebrate":[322],"CNS.":[323],"produces":[326],"CNS":[331],"blocked":[335],"receptor":[338],"antagonists.":[339],"Other":[340],"mechanisms,":[341],"Na+/K(+)-ATPase":[345],"activity,":[346],"cAMP/cGMP":[347],"calcium":[350],"currents":[351],"pre-":[353],"postsynaptic":[355],"membranes,":[356],"also":[358],"least":[361],"partially":[362],"responsible":[363],"effects":[367],"associated":[368],"low":[370],"Further":[373],"studies":[374],"necessary":[376],"our":[379],"understanding":[380],"implications":[384],"deficit":[387],"central":[390],"nervous":[391],"system.":[392]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}