{"id":"https://openalex.org/W81983803","doi":null,"title":"Use of extracellular vesicles as biomarker for disease or as therapeutic target","display_name":"Use of extracellular vesicles as biomarker for disease or as therapeutic target","publication_year":2012,"publication_date":"2012-08-16","ids":{"openalex":"https://openalex.org/W81983803","mag":"81983803"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/253294","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/253294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/253294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038380886","display_name":"Heleen H. Vroman","orcid":"https://orcid.org/0000-0002-4392-935X","observed_orcids":["https://orcid.org/0000-0002-4392-935X","https://orcid.org/0000-0001-6169-7671"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heleen Vroman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038380886"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8669999837875366},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7080000042915344},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.8180000185966492},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":1.0},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8790000081062317},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7160000205039978},{"id":"https://openalex.org/keywords/mrna-transfer","display_name":"mRNA transfer","score":0.5479999780654907},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.671999990940094},{"id":"https://openalex.org/keywords/disease-diagnosis","display_name":"disease diagnosis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/disease-therapy","display_name":"disease therapy","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9102029800415039},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.8036710023880005},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7795738577842712},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7523043155670166},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.720098078250885},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6436250805854797},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.5253942608833313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42954784631729126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40876322984695435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4080123007297516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23526570200920105},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.19702333211898804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/253294","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/253294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:81983803","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/253294/scriptie%20vroman%20final.pdf;sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/253294","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/253294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W32984090","https://openalex.org/W190241378","https://openalex.org/W1511964634","https://openalex.org/W1527671059","https://openalex.org/W1538522759","https://openalex.org/W1542448731","https://openalex.org/W1571387405","https://openalex.org/W1574663134","https://openalex.org/W1587942505","https://openalex.org/W1621522521","https://openalex.org/W1639310471","https://openalex.org/W1660842594","https://openalex.org/W1698471795","https://openalex.org/W1781511708","https://openalex.org/W1792460785","https://openalex.org/W1804501722","https://openalex.org/W1838162521","https://openalex.org/W1874379912","https://openalex.org/W1877686344","https://openalex.org/W1886462611","https://openalex.org/W1889489351","https://openalex.org/W1893364625","https://openalex.org/W1964232997","https://openalex.org/W1965361683","https://openalex.org/W1965774359","https://openalex.org/W1967367827","https://openalex.org/W1972365386","https://openalex.org/W1974019238","https://openalex.org/W1974209230","https://openalex.org/W1974954833","https://openalex.org/W1977613047","https://openalex.org/W1977692564","https://openalex.org/W1979751563","https://openalex.org/W1980593265","https://openalex.org/W1984472621","https://openalex.org/W1986321004","https://openalex.org/W1987019376","https://openalex.org/W1987357218","https://openalex.org/W1987409881","https://openalex.org/W1988249798","https://openalex.org/W1989654403","https://openalex.org/W1991897454","https://openalex.org/W1992041389","https://openalex.org/W1992481740","https://openalex.org/W1994547407","https://openalex.org/W1996491835","https://openalex.org/W1996687875","https://openalex.org/W1997521359","https://openalex.org/W1997791437","https://openalex.org/W2002642324","https://openalex.org/W2003810866","https://openalex.org/W2011715000","https://openalex.org/W2017669919","https://openalex.org/W2019823845","https://openalex.org/W2019888542","https://openalex.org/W2019917125","https://openalex.org/W2020844013","https://openalex.org/W2022027327","https://openalex.org/W2022169355","https://openalex.org/W2022717756","https://openalex.org/W2025752793","https://openalex.org/W2026528573","https://openalex.org/W2027342684","https://openalex.org/W2028248159","https://openalex.org/W2028368510","https://openalex.org/W2028622306","https://openalex.org/W2030677933","https://openalex.org/W2030701238","https://openalex.org/W2031325281","https://openalex.org/W2033598310","https://openalex.org/W2034238925","https://openalex.org/W2035650290","https://openalex.org/W2035844407","https://openalex.org/W2036816398","https://openalex.org/W2038509755","https://openalex.org/W2041302454","https://openalex.org/W2046783628","https://openalex.org/W2047159195","https://openalex.org/W2047699811","https://openalex.org/W2047960154","https://openalex.org/W2048353869","https://openalex.org/W2053900146","https://openalex.org/W2054410308","https://openalex.org/W2054637102","https://openalex.org/W2055313665","https://openalex.org/W2055424631","https://openalex.org/W2056952890","https://openalex.org/W2057155093","https://openalex.org/W2059435371","https://openalex.org/W2062649816","https://openalex.org/W2063480251","https://openalex.org/W2064448614","https://openalex.org/W2064552877","https://openalex.org/W2065236536","https://openalex.org/W2067271905","https://openalex.org/W2068692565","https://openalex.org/W2074156609","https://openalex.org/W2077773656","https://openalex.org/W2079964366","https://openalex.org/W2080879611","https://openalex.org/W2084271408","https://openalex.org/W2085747301","https://openalex.org/W2086077027","https://openalex.org/W2088743816","https://openalex.org/W2089081493","https://openalex.org/W2089154872","https://openalex.org/W2091745370","https://openalex.org/W2099491642","https://openalex.org/W2102135956","https://openalex.org/W2102387114","https://openalex.org/W2102435627","https://openalex.org/W2102997746","https://openalex.org/W2104733960","https://openalex.org/W2106261547","https://openalex.org/W2109694492","https://openalex.org/W2111533160","https://openalex.org/W2111560326","https://openalex.org/W2111778115","https://openalex.org/W2118698517","https://openalex.org/W2119043140","https://openalex.org/W2128214810","https://openalex.org/W2130382041","https://openalex.org/W2131409719","https://openalex.org/W2132370967","https://openalex.org/W2136755383","https://openalex.org/W2138176073","https://openalex.org/W2138751320","https://openalex.org/W2139491529","https://openalex.org/W2142433114","https://openalex.org/W2142598717","https://openalex.org/W2142639362","https://openalex.org/W2143580680","https://openalex.org/W2145718840","https://openalex.org/W2146865049","https://openalex.org/W2147854273","https://openalex.org/W2152915643","https://openalex.org/W2153040610","https://openalex.org/W2153840858","https://openalex.org/W2155366992","https://openalex.org/W2157194244","https://openalex.org/W2160968516","https://openalex.org/W2162159732","https://openalex.org/W2162778644","https://openalex.org/W2166595775","https://openalex.org/W2167056256","https://openalex.org/W2167497075","https://openalex.org/W2168044494","https://openalex.org/W2169599832","https://openalex.org/W2169966070","https://openalex.org/W2171618078","https://openalex.org/W2181501130","https://openalex.org/W2189240108","https://openalex.org/W2328883326","https://openalex.org/W2330292521","https://openalex.org/W2414898396","https://openalex.org/W4233116228"],"related_works":["https://openalex.org/W2794844203","https://openalex.org/W2007652184","https://openalex.org/W4391551503","https://openalex.org/W4313200508","https://openalex.org/W2804246866","https://openalex.org/W3082403158","https://openalex.org/W2478602097","https://openalex.org/W2889806779","https://openalex.org/W3145156819","https://openalex.org/W2786514708"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"novel":[3],"ways":[4],"of":[5,45,48,65,69,100,121,135],"intercellular":[6],"communication":[7],"have":[8],"been":[9],"described":[10],"involving":[11],"extracellular":[12,24,63,88,136],"vesicles.":[13],"Cells":[14],"from":[15,31],"various":[16,144],"origins":[17],"actively":[18],"release":[19,64],"small":[20],"vesicles":[21,68,89,105,137],"into":[22],"the":[23,32,46,49,54,62,66,98,101,116,133],"environment":[25],"either":[26],"by":[27,87,115],"pinching":[28],"off":[29],"directly":[30],"plasma":[33,55],"membrane,":[34],"which":[35,71],"are":[36,72,85,113],"often":[37],"referred":[38],"to":[39,93],"as":[40,138],"microvesicles,":[41],"or":[42],"a":[43],"consequence":[44],"fusion":[47],"multivesicular":[50],"body":[51],"(MVB)":[52],"with":[53],"membrane.":[56],"The":[57],"latter":[58],"process":[59],"results":[60],"in":[61,143],"intraluminal":[67],"MVB,":[70],"now":[73],"termed":[74],"exosomes.":[75],"Cytosolic":[76],"proteins,":[77],"mRNAs,":[78],"miRNAs":[79],"and":[80,109,125,140],"membrane":[81],"bound":[82],"proteins":[83],"that":[84,112],"contained":[86],"can":[90],"be":[91],"transferred":[92],"target":[94,102],"cells,":[95],"thereby":[96],"altering":[97],"physiology":[99],"cell.":[103],"Extracellular":[104],"display":[106],"unique":[107],"biophysical":[108],"biochemical":[110],"features":[111],"determined":[114],"originating":[117],"cell,":[118],"making":[119],"them":[120],"interest":[122],"for":[123],"diagnostic":[124],"therapeutic":[126,141],"purposes.":[127],"This":[128],"thesis":[129],"will":[130],"focus":[131],"on":[132],"potential":[134],"biomarker":[139],"agent":[142],"diseases.":[145]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}