{"id":"https://openalex.org/W81975643","doi":null,"title":"Cancer stem cell marker in circulating tumor cells: expression of CD44 variant exon 9 is strongly correlated to treatment refractoriness, recurrence and prognosis of human colorectal cancer.","display_name":"Cancer stem cell marker in circulating tumor cells: expression of CD44 variant exon 9 is strongly correlated to treatment refractoriness, recurrence and prognosis of human colorectal cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W81975643","mag":"81975643","pmid":"https://pubmed.ncbi.nlm.nih.gov/25550556"},"language":"en","primary_location":{"id":"pmid:25550556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25550556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shigeru Katoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Katoh","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042852320","display_name":"Takanori Goi","orcid":"https://orcid.org/0000-0001-7671-0648","observed_orcids":["https://orcid.org/0000-0001-7671-0648"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Goi","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan tgoi@u-fukui.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan tgoi@u-fukui.ac.jp","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036214744","display_name":"Takayuki Naruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Naruse","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747798","display_name":"Yuki Ueda","orcid":"https://orcid.org/0009-0003-8400-3304","observed_orcids":["https://orcid.org/0009-0003-8400-3304"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Ueda","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hidetaka Kurebayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetaka Kurebayashi","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toshiyuki Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Nakazawa","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053883269","display_name":"Youhei Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youhei Kimura","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112310768","display_name":"Yasuo Hirono","orcid":"https://orcid.org/0000-0002-3943-0636","observed_orcids":["https://orcid.org/0000-0002-3943-0636"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Hirono","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113591837","display_name":"Akio Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Yamaguchi","raw_affiliation_strings":["First Department of Surgery, University of Fukui, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, University of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111966504"],"apc_list":null,"apc_paid":null,"fwci":3.7432,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95201359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"1","first_page":"239","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44v9","display_name":"CD44v9","score":0.9120000004768372},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/treatment-refractoriness","display_name":"treatment refractoriness","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5320000052452087},{"id":"https://openalex.org/keywords/stage-iii-colorectal-cancer","display_name":"stage III colorectal cancer","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.8007485866546631},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7835574150085449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6523432731628418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5903218984603882},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5589799880981445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49802231788635254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4787794351577759},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47065606713294983},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.4686289131641388},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.4651400148868561},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4429207444190979},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.4162828028202057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3451943099498749},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3075111508369446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28701743483543396},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.16880139708518982},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25550556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25550556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:81975643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25550556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1776471368","https://openalex.org/W1791208773","https://openalex.org/W1854105605","https://openalex.org/W1870544273","https://openalex.org/W1981989535","https://openalex.org/W1982603620","https://openalex.org/W1985804036","https://openalex.org/W1990423062","https://openalex.org/W1992514491","https://openalex.org/W1994236074","https://openalex.org/W1996787107","https://openalex.org/W2001544973","https://openalex.org/W2004556453","https://openalex.org/W2018138709","https://openalex.org/W2023427658","https://openalex.org/W2029231546","https://openalex.org/W2036045525","https://openalex.org/W2040544223","https://openalex.org/W2041399911","https://openalex.org/W2045412281","https://openalex.org/W2051055358","https://openalex.org/W2074982201","https://openalex.org/W2081447858","https://openalex.org/W2089586603","https://openalex.org/W2090562908","https://openalex.org/W2090982381","https://openalex.org/W2101711321","https://openalex.org/W2117158095","https://openalex.org/W2128403792","https://openalex.org/W2133678043","https://openalex.org/W2134354590","https://openalex.org/W2138665978","https://openalex.org/W2140372606","https://openalex.org/W2141033682","https://openalex.org/W2142790807","https://openalex.org/W2151293992","https://openalex.org/W2165828398","https://openalex.org/W2442397884"],"related_works":["https://openalex.org/W2288946462","https://openalex.org/W4394962666","https://openalex.org/W2064327144","https://openalex.org/W4366424895","https://openalex.org/W1643169874","https://openalex.org/W3008294519","https://openalex.org/W1776471368","https://openalex.org/W7095684026","https://openalex.org/W2737429647","https://openalex.org/W2133678043"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"The":[1],"expression":[2,57,73,107,126,133],"of":[3,58,67,74,131,141],"the":[4,46,54,87,116,139],"CD44":[5],"variant":[6],"exon":[7],"9":[8],"(CD44v9)":[9],"was":[10,35,77,91,101,120],"investigated":[11],"in":[12,22,79,103,122,129,138],"order":[13],"to":[14],"elucidate":[15],"its":[16],"significance":[17],"for":[18,93],"cancer":[19,26,143],"stem":[20],"cells":[21,27],"circulating":[23],"human":[24],"colorectal":[25,40,71,142],"(CTCs).":[28],"MATERIALS":[29],"AND":[30],"METHODS:":[31],"After":[32],"peripheral":[33],"blood":[34],"drawn":[36],"from":[37],"patients":[38,69,82,94,104,110],"with":[39,70,83,95,105,111,124],"cancer,":[41,72,115],"CTCs":[42,140],"were":[43],"collected.":[44],"Using":[45],"reverse":[47],"transcription-polymerase":[48],"chain":[49],"reaction":[50],"method,":[51],"we":[52],"examined":[53],"relationship":[55],"between":[56],"CD44v9":[59,75,97,136],"mRNA":[60,76,137],"and":[61,127,152],"prognosis.":[62],"RESULTS:":[63],"In":[64,81,109],"60":[65],"out":[66],"150":[68],"positive":[78,106,132],"CTCs.":[80],"stage":[84,112],"III":[85],"disease,":[86],"5-year":[88],"survival":[89,118],"rate":[90,119],"89%":[92],"negative":[96],"expression,":[98],"whereas":[99],"it":[100],"52.4%":[102],"(p<0.05).":[108,134],"IV":[113],"unresectable":[114],"2-year":[117],"70.1%":[121],"cases":[123,130],"CD44v9-negative":[125],"33.3%":[128],"CONCLUSION:":[135],"is":[144],"useful":[145],"as":[146],"a":[147],"factor":[148],"predicting":[149],"recurrence,":[150],"prognosis,":[151],"treatment":[153],"efficacy.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}