{"id":"https://openalex.org/W818580342","doi":null,"title":"Effect of S-Allyl Cysteine(SAC) on the Proliferation of Umbilical Cord Blood(UCB)-derived Mesenchymal Stem Cells(MSCs)","display_name":"Effect of S-Allyl Cysteine(SAC) on the Proliferation of Umbilical Cord Blood(UCB)-derived Mesenchymal Stem Cells(MSCs)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W818580342","mag":"818580342"},"language":"en","primary_location":{"id":"mag:818580342","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HGSPB1_2009_v22n2_313","pdf_url":null,"source":{"id":"https://openalex.org/S2911951769","display_name":"The Korean Journal of Food And Nutrition","issn_l":"1225-4339","issn":["1225-4339","2287-4992"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4360969338","host_organization_name":"The Korean Society of Food and Nutrition","host_organization_lineage":["https://openalex.org/P4360969338"],"host_organization_lineage_names":["The Korean Society of Food and Nutrition"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Food And Nutrition","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031889886","display_name":"Ran-Sook Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ran-Sook Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031889886"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0994,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43217553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"2","first_page":"313","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-allyl-cysteine","display_name":"S-allylcysteine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8489999771118164},{"id":"https://openalex.org/keywords/garlic-extract","display_name":"garlic extract","score":0.7059999704360962},{"id":"https://openalex.org/keywords/in-vitro-culture","display_name":"in vitro culture","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8342688679695129},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6325029730796814},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6279710531234741},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6110153198242188},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5602404475212097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5541417598724365},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.45292484760284424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43833717703819275},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4271852970123291},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4117200970649719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2744410037994385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2687925696372986}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:818580342","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HGSPB1_2009_v22n2_313","pdf_url":null,"source":{"id":"https://openalex.org/S2911951769","display_name":"The Korean Journal of Food And Nutrition","issn_l":"1225-4339","issn":["1225-4339","2287-4992"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4360969338","host_organization_name":"The Korean Society of Food and Nutrition","host_organization_lineage":["https://openalex.org/P4360969338"],"host_organization_lineage_names":["The Korean Society of Food and Nutrition"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Food And Nutrition","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W28068361","https://openalex.org/W1933364203","https://openalex.org/W1983216781","https://openalex.org/W2009744898","https://openalex.org/W2030128711","https://openalex.org/W2059178011","https://openalex.org/W2074625690","https://openalex.org/W2083123206","https://openalex.org/W2085879016","https://openalex.org/W2160823360","https://openalex.org/W2738275571"],"related_works":["https://openalex.org/W2015854906","https://openalex.org/W2506384912","https://openalex.org/W2898621850","https://openalex.org/W1978366029","https://openalex.org/W2087392681","https://openalex.org/W2754762928","https://openalex.org/W7028237301","https://openalex.org/W2280510255","https://openalex.org/W4409562021","https://openalex.org/W7204436650"],"abstract_inverted_index":{"To":[0,69],"improve":[1,61],"the":[2,20,31,62,71,78,82,100,108,113,120,137,143,170,173,182],"growth":[3,63,152],"of":[4,22,34,64,74,81,102,116,124,139,146,159,172,176,184,188,194,211,220],"human":[5,212,221],"mesenchymal":[6],"stem":[7],"cells(hMSCs)":[8],"under":[9],"general":[10],"cell":[11,51,144,151,156,190],"culture":[12,158,209],"conditions(20%":[13],"O2":[14],"and":[15,30,53,89,105,127,142,217],"5%":[16],"CO2),":[17],"we":[18,76],"examined":[19,77],"effect":[21,73],"s-allylcysteine(SAC),":[23],"which":[24],"is":[25],"known":[26],"as":[27],"an":[28,202,206],"antioxidant":[29,83,140,195],"main":[32],"component":[33,204],"aged-garlic":[35],"extract,":[36],"on":[37],"hydrogen":[38,49,121],"peroxide-induced":[39,122],"cellular":[40,54],"stress":[41],"in":[42,92,112,153,169,205,207],"hMSCs.":[43,93,147,160,177],"We":[44],"found":[45,97],"that":[46,57,164],"SAC":[47,58,118,132,149,165,180,199],"blocked":[48],"peroxideinduced":[50],"death":[52],"apoptosis,":[55],"but":[56],"did":[59,134],"not":[60,135],"hMSCs":[65,185],"during":[66],"short-term":[67],"culture.":[68],"evaluate":[70],"protective":[72],"SAC,":[75,117],"endogenous":[79],"expression":[80,101],"enzymes":[84,141],"catalase":[85],"(CAT),":[86],"superoxide":[87],"dismutase(SOD),":[88],"glutathione":[90],"peroxidase(Gpx)":[91],"Hydrogen":[94],"peroxide":[95],"was":[96],"to":[98],"downregulate":[99],"CAT,":[103,125],"SOD,":[104,126],"Gpx":[106],"at":[107],"protein":[109],"level.":[110],"However,":[111],"pre-treatment":[114],"group":[115],"inhibited":[119],"down-regulation":[123],"Gpx.":[128],"Unfortunately,":[129],"treatment":[130],"with":[131],"alone":[133],"induce":[136],"up-regulation":[138],"proliferation":[145,183],"Surprisingly,":[148],"improved":[150],"a":[154],"single":[155],"level":[157],"These":[161],"results":[162],"indicate":[163],"may":[166,200],"be":[167,201],"involved":[168],"preservation":[171],"self-renewal":[174,216],"capacity":[175],"Taken":[178],"together,":[179],"improves":[181],"via":[186],"inhibition":[187],"oxidativestress-induced":[189],"apoptosis":[191],"through":[192],"regulation":[193],"enzymes.":[196],"In":[197],"conclusion,":[198],"indispensable":[203],"vitro":[208],"system":[210],"MSCs":[213],"for":[214],"maintaining":[215],"multipotent":[218],"characterization":[219],"MSCs.":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}