{"id":"https://openalex.org/W81820604","doi":null,"title":"Treatment of mild to moderate facial melasma with the Lumixyl topical brightening system.","display_name":"Treatment of mild to moderate facial melasma with the Lumixyl topical brightening system.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W81820604","mag":"81820604","pmid":"https://pubmed.ncbi.nlm.nih.gov/22527440"},"language":"en","primary_location":{"id":"pmid:22527440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22527440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039463477","display_name":"Basil M. Hantash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basil M Hantash","raw_affiliation_strings":["Elixir Institute of Regenerative Medicine, San Jose, CA, USA. basil@elixirinstitute.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elixir Institute of Regenerative Medicine, San Jose, CA, USA. basil@elixirinstitute.org","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Felipe Jimenez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felipe Jimenez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8126,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83298086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"11","issue":"5","first_page":"660","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.1476999968290329,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melasma","display_name":"melasma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oligopeptides","display_name":"oligopeptides","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tyrosinase-inhibition","display_name":"tyrosinase inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glycolic-acid","display_name":"glycolic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sunscreen","display_name":"sunscreen","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2776677263","wikidata":"https://www.wikidata.org/wiki/Q305190","display_name":"Melasma","level":2,"score":0.9853495359420776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9012980461120605},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7351004481315613},{"id":"https://openalex.org/C2780986958","wikidata":"https://www.wikidata.org/wiki/Q1871151","display_name":"Lotion","level":2,"score":0.7189668416976929},{"id":"https://openalex.org/C2780941728","wikidata":"https://www.wikidata.org/wiki/Q17990675","display_name":"Cleanser","level":2,"score":0.572658121585846},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.546191930770874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2198256552219391},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10398879647254944},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09498631954193115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005145","descriptor_name":"Face","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22527440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22527440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Case Reports"},{"id":"mag:81820604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22527440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W103703410","https://openalex.org/W2415875348","https://openalex.org/W2256745465","https://openalex.org/W3095425236","https://openalex.org/W2916881945","https://openalex.org/W2172101224","https://openalex.org/W2945989165","https://openalex.org/W3160894884","https://openalex.org/W4318614941","https://openalex.org/W3096320205"],"abstract_inverted_index":{"BACKGROUND:":[0],"Melasma":[1],"is":[2],"a":[3,109],"cutaneous":[4],"disorder":[5],"associated":[6,34],"with":[7,89],"an":[8,65],"overproduction":[9],"of":[10,36,43,49,77,91],"melanin":[11],"by":[12],"the":[13,33,41,57],"tyrosinase":[14,29],"enzyme.":[15],"A":[16],"proprietary":[17],"oligopeptide":[18,63],"(Lumixyl\u2122)":[19],"was":[20,53],"previously":[21],"shown":[22],"to":[23,39,54,113,116],"competitively":[24],"inhibit":[25],"mushroom":[26],"and":[27,38,72],"human":[28],"in":[30,85],"vitro":[31],"without":[32],"cytotoxicity":[35],"hydroquinone":[37],"diminish":[40],"appearance":[42],"facial":[44,87],"melasma.":[45,79,118],"OBJECTIVE:":[46],"The":[47],"aim":[48],"this":[50,105],"case":[51],"study":[52],"determine":[55],"if":[56],"Lumixyl":[58],"Topical":[59],"Brightening":[60],"System":[61],"(0.01%":[62],"cream,":[64],"antioxidant":[66],"cleanser,":[67],"20%":[68],"glycolic":[69],"acid":[70],"lotion":[71],"physical":[73],"sunscreen)":[74],"accelerates":[75],"clearance":[76,96],"mild-to-moderate":[78],"RESULTS:":[80],"All":[81],"patients":[82,93],"showed":[83],"improvement":[84],"their":[86],"melasma":[88],"1":[90],"4":[92],"showing":[94],"complete":[95],"after":[97],"just":[98],"6":[99],"weeks.":[100],"CONCLUSIONS:":[101],"Results":[102],"suggest":[103],"that":[104],"regimen":[106],"may":[107],"be":[108],"useful":[110],"new":[111],"tool":[112],"treat":[114],"mild":[115],"moderate":[117]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
