{"id":"https://openalex.org/W81762285","doi":null,"title":"Novel Methods for Analysis of Heterogeneous Protein-Cell Interactions : Resolving How the Epidermal Growth Factor Binds to Its Receptor","display_name":"Novel Methods for Analysis of Heterogeneous Protein-Cell Interactions : Resolving How the Epidermal Growth Factor Binds to Its Receptor","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W81762285","mag":"81762285"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-183872","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083279208","display_name":"Hanna Bj\u00f6rkelund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hanna Bj\u00f6rkelund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083279208"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/egf-binding","display_name":"EGF binding","score":0.6230000257492065},{"id":"https://openalex.org/keywords/interaction-maps","display_name":"interaction maps","score":0.7080000042915344},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.7080000042915344},{"id":"https://openalex.org/keywords/parallel-interaction","display_name":"parallel interaction","score":0.5360000133514404},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.7680000066757202},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9599999785423279},{"id":"https://openalex.org/keywords/receptor-degradation","display_name":"receptor degradation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5007390975952148},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.4884440004825592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4857678711414337},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.43405386805534363},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42648231983184814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41083937883377075},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39701730012893677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3513147830963135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3478403687477112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21688801050186157},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-183872","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:81762285","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:574810/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-183872","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W143368611","https://openalex.org/W186492568","https://openalex.org/W262529754","https://openalex.org/W1493773816","https://openalex.org/W1521274794","https://openalex.org/W1523413020","https://openalex.org/W1579258114","https://openalex.org/W1590794385","https://openalex.org/W1733847523","https://openalex.org/W1964321121","https://openalex.org/W1966494834","https://openalex.org/W1969808504","https://openalex.org/W1974024530","https://openalex.org/W1987125144","https://openalex.org/W1989837159","https://openalex.org/W1991068964","https://openalex.org/W1992507321","https://openalex.org/W1993880825","https://openalex.org/W1994421815","https://openalex.org/W1995993550","https://openalex.org/W1996721080","https://openalex.org/W1997151560","https://openalex.org/W1998646888","https://openalex.org/W1999513758","https://openalex.org/W2001627828","https://openalex.org/W2003487510","https://openalex.org/W2005481172","https://openalex.org/W2009915001","https://openalex.org/W2011971876","https://openalex.org/W2016408686","https://openalex.org/W2022039302","https://openalex.org/W2026394641","https://openalex.org/W2029532166","https://openalex.org/W2034269086","https://openalex.org/W2037117268","https://openalex.org/W2043826980","https://openalex.org/W2045156702","https://openalex.org/W2045158653","https://openalex.org/W2048287651","https://openalex.org/W2049938167","https://openalex.org/W2052465009","https://openalex.org/W2083339266","https://openalex.org/W2092710950","https://openalex.org/W2095381863","https://openalex.org/W2095472784","https://openalex.org/W2101849511","https://openalex.org/W2107022635","https://openalex.org/W2118104220","https://openalex.org/W2118320591","https://openalex.org/W2120234899","https://openalex.org/W2120718661","https://openalex.org/W2121473111","https://openalex.org/W2125608197","https://openalex.org/W2127465345","https://openalex.org/W2128307445","https://openalex.org/W2129936304","https://openalex.org/W2131711073","https://openalex.org/W2133051701","https://openalex.org/W2134446796","https://openalex.org/W2143651667","https://openalex.org/W2143827494","https://openalex.org/W2151028908","https://openalex.org/W2151395731","https://openalex.org/W2156779720","https://openalex.org/W2158062848","https://openalex.org/W2163002589","https://openalex.org/W2169816570","https://openalex.org/W2170147411","https://openalex.org/W2465591554","https://openalex.org/W2526417661"],"related_works":["https://openalex.org/W1987125144","https://openalex.org/W1895950227","https://openalex.org/W7095907489","https://openalex.org/W3108297590","https://openalex.org/W2157383338","https://openalex.org/W2740152837","https://openalex.org/W2161682775","https://openalex.org/W2004156654","https://openalex.org/W2092133543","https://openalex.org/W2211041313"],"abstract_inverted_index":{"Cells":[0],"are":[1,27,70],"complex":[2,301],"biological":[3,130,225],"units":[4],"with":[5,132,243,254],"advanced":[6],"signalling":[7],"systems,":[8,131],"a":[9,94,110,193,215,229],"dynamic":[10],"capacity":[11],"to":[12,14,20,43,72,100,127,160,210,262],"adapt":[13],"its":[15],"environment,":[16],"and":[17,22,105,145,153,165,183,197,203,270,280,291,306,319],"the":[18,54,122,139,201,211,223,234,250,263,284,298,311],"ability":[19],"divide":[21],"grow.":[23],"In":[24,283],"fact,":[25],"they":[26],"of":[28,32,89,113,124,141,188,205,218,233,288,293,300,310,321],"such":[29,103,227,265],"high":[30],"level":[31,112],"complexity":[33],"that":[34,208],"it":[35,97],"has":[36,56],"deemed":[37],"extremely":[38],"difficult":[39],"or":[40],"even":[41],"impossible":[42],"completely":[44],"understand":[45],"cells":[46,305],"as":[47,169,171,228,266],"complete":[48],"units.":[49],"The":[50,76,231],"search":[51],"for":[52,85,150],"comprehending":[53],"cell":[55,74,107,315],"instead":[57],"been":[58],"divided":[59],"into":[60],"small,":[61],"relatively":[62],"isolated":[63],"research":[64],"fields,":[65],"in":[66,158,222,272,304],"which":[67],"simplified":[68],"models":[69],"used":[71],"explain":[73,308],"biology.":[75,90],"result":[77],"produced":[78],"through":[79],"these":[80],"reductionistic":[81],"investigations":[82],"is":[83,98,117],"integral":[84],"our":[86],"current":[87],"description":[88],"However,":[91],"there":[92],"comes":[93],"time":[95,116,168],"when":[96],"possible":[99],"go":[101],"beyond":[102],"simplifications":[104],"investigate":[106,128],"biology":[108],"at":[109],"higher":[111],"complexity.":[114],"That":[115],"now.":[118],"This":[119,213],"thesis":[120],"describes":[121],"development":[123],"mathematical":[125],"tools":[126],"intricate":[129],"focus":[133],"on":[134,185,200,247],"heterogeneous":[135],"protein":[136],"interactions.":[137,189],"By":[138,258],"use":[140],"simulations,":[142],"real-time":[143],"measurements":[144,152],"kinetic":[146],"fits,":[147],"standard":[148],"assays":[149],"specificity":[151],"receptor":[154,238],"quantification":[155],"were":[156],"scrutinized":[157],"order":[159],"find":[161],"optimal":[162],"experimental":[163],"settings":[164],"reduce":[166],"labour":[167],"well":[170],"reagent":[172],"cost.":[173],"A":[174],"novel":[175],"analysis":[176,287],"platform,":[177],"called":[178],"Interaction":[179,190,244],"Map,":[180],"was":[181,241,275],"characterized":[182],"applied":[184,246],"several":[186],"types":[187],"Map":[191,245],"decomposes":[192],"time-resolved":[194],"binding":[195,289],"curve":[196],"presents":[198],"information":[199,274],"kinetics":[202,290],"magnitude":[204],"each":[206],"interaction":[207],"contributed":[209],"curve.":[212],"provides":[214],"greater":[216],"understanding":[217,299],"parallel":[219,294],"interactions":[220,295],"involved":[221],"same":[224],"system,":[226,264],"cell.":[230],"heterogeneity":[232],"epidermal":[235],"growth":[236],"factor":[237],"(EGFR)":[239],"system":[240],"investigated":[242],"data":[248],"from":[249],"instrument":[251],"LigandTracer,":[252],"together":[253],"complementing":[255],"manual":[256],"assays.":[257],"further":[259],"introducing":[260],"disturbances":[261],"tyrosine":[267],"kinase":[268],"inhibitors":[269],"variation":[271],"temperature,":[273],"obtained":[276],"about":[277],"dimerization,":[278],"internalization":[279],"degradation":[281],"rates.":[282],"long":[285],"term,":[286],"combinations":[292],"can":[296],"improve":[297],"biomolecular":[302],"mechanisms":[303],"may":[307],"some":[309],"differences":[312],"observed":[313],"between":[314],"lines,":[316],"medical":[317],"treatments":[318],"groups":[320],"patients.":[322]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}