{"id":"https://openalex.org/W81694641","doi":null,"title":"INFLAMMATORY INTERACTIONS AND SECRETION IN CARDIAC REMODELING","display_name":"INFLAMMATORY INTERACTIONS AND SECRETION IN CARDIAC REMODELING","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W81694641","mag":"81694641"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1003","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/4","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1003&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1003&context=physiology_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010764532","display_name":"Fanmuyi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fanmuyi Yang","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010764532"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00922583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perivascular-inflammation","display_name":"perivascular inflammation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.7400000095367432},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/platelet-secretion","display_name":"platelet secretion","score":0.4950000047683716},{"id":"https://openalex.org/keywords/platelet-leukocyte-aggregates","display_name":"platelet-leukocyte aggregates","score":0.8169999718666077},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9430000185966492},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.824999988079071},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-remodeling","display_name":"coronary artery remodeling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/rag1-knockout-mice","display_name":"Rag1 knockout mice","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/unc13d","display_name":"UNC13D","score":0.7689999938011169},{"id":"https://openalex.org/keywords/munc13-4","display_name":"Munc13-4","score":0.9070000052452087},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/granule-secretion","display_name":"granule secretion","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7291003465652466},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7277489304542542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6834976673126221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5558764934539795},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.5422907471656799},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5371513962745667},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4886668026447296},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.46332332491874695},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.4484795928001404},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3648127019405365},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.36249613761901855},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3399275541305542},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.08490657806396484}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1003","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/4","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1003&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},{"id":"mag:81694641","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1003&context=physiology_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1003","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/4","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1003&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W81694641.pdf","grobid_xml":"https://content.openalex.org/works/W81694641.grobid-xml"},"referenced_works_count":219,"referenced_works":["https://openalex.org/W64881117","https://openalex.org/W76085819","https://openalex.org/W159023803","https://openalex.org/W176610512","https://openalex.org/W187770661","https://openalex.org/W196835504","https://openalex.org/W203172443","https://openalex.org/W252852947","https://openalex.org/W274441265","https://openalex.org/W323469003","https://openalex.org/W340085114","https://openalex.org/W1219610608","https://openalex.org/W1547732923","https://openalex.org/W1549428994","https://openalex.org/W1553698258","https://openalex.org/W1556110303","https://openalex.org/W1568609601","https://openalex.org/W1571387405","https://openalex.org/W1571864484","https://openalex.org/W1924964862","https://openalex.org/W1963641274","https://openalex.org/W1964458777","https://openalex.org/W1964607696","https://openalex.org/W1967948987","https://openalex.org/W1968363823","https://openalex.org/W1971822850","https://openalex.org/W1972429479","https://openalex.org/W1978930347","https://openalex.org/W1979998030","https://openalex.org/W1981079220","https://openalex.org/W1981469121","https://openalex.org/W1982782750","https://openalex.org/W1982922130","https://openalex.org/W1983318857","https://openalex.org/W1984427686","https://openalex.org/W1986636360","https://openalex.org/W1987748845","https://openalex.org/W1987945386","https://openalex.org/W1989222067","https://openalex.org/W1989610794","https://openalex.org/W1990999296","https://openalex.org/W1991343266","https://openalex.org/W1993157664","https://openalex.org/W1993209978","https://openalex.org/W1994008257","https://openalex.org/W1996501071","https://openalex.org/W1996660997","https://openalex.org/W1998153400","https://openalex.org/W1998503381","https://openalex.org/W1998596192","https://openalex.org/W2001926720","https://openalex.org/W2002526685","https://openalex.org/W2002629699","https://openalex.org/W2004796256","https://openalex.org/W2006906257","https://openalex.org/W2008434058","https://openalex.org/W2008920235","https://openalex.org/W2011181015","https://openalex.org/W2011476242","https://openalex.org/W2011768933","https://openalex.org/W2011813460","https://openalex.org/W2012194278","https://openalex.org/W2014197706","https://openalex.org/W2015038971","https://openalex.org/W2015713712","https://openalex.org/W2015984692","https://openalex.org/W2017322109","https://openalex.org/W2019894008","https://openalex.org/W2020043514","https://openalex.org/W2021253310","https://openalex.org/W2023639075","https://openalex.org/W2024720251","https://openalex.org/W2026810294","https://openalex.org/W2026933863","https://openalex.org/W2027080624","https://openalex.org/W2028074260","https://openalex.org/W2028689554","https://openalex.org/W2030968333","https://openalex.org/W2031431176","https://openalex.org/W2032024481","https://openalex.org/W2032811951","https://openalex.org/W2034336585","https://openalex.org/W2037200837","https://openalex.org/W2037493697","https://openalex.org/W2037749195","https://openalex.org/W2038663122","https://openalex.org/W2038825926","https://openalex.org/W2039059719","https://openalex.org/W2040030790","https://openalex.org/W2040103773","https://openalex.org/W2040628293","https://openalex.org/W2041636354","https://openalex.org/W2042619626","https://openalex.org/W2042921846","https://openalex.org/W2043040664","https://openalex.org/W2043770386","https://openalex.org/W2045253038","https://openalex.org/W2045545111","https://openalex.org/W2045571319","https://openalex.org/W2046553750","https://openalex.org/W2048035055","https://openalex.org/W2048804108","https://openalex.org/W2048837254","https://openalex.org/W2049099241","https://openalex.org/W2049727526","https://openalex.org/W2052073826","https://openalex.org/W2052110444","https://openalex.org/W2052547401","https://openalex.org/W2055080287","https://openalex.org/W2055429591","https://openalex.org/W2055998280","https://openalex.org/W2056566791","https://openalex.org/W2057191687","https://openalex.org/W2060072724","https://openalex.org/W2060175659","https://openalex.org/W2060516690","https://openalex.org/W2060945377","https://openalex.org/W2061457959","https://openalex.org/W2063441753","https://openalex.org/W2064191380","https://openalex.org/W2066551044","https://openalex.org/W2067511487","https://openalex.org/W2068887026","https://openalex.org/W2069717173","https://openalex.org/W2069786094","https://openalex.org/W2069830368","https://openalex.org/W2069927604","https://openalex.org/W2071799762","https://openalex.org/W2072052992","https://openalex.org/W2072271957","https://openalex.org/W2072816942","https://openalex.org/W2074156641","https://openalex.org/W2074209621","https://openalex.org/W2075183184","https://openalex.org/W2075820100","https://openalex.org/W2079556095","https://openalex.org/W2079709663","https://openalex.org/W2082552456","https://openalex.org/W2084224210","https://openalex.org/W2084784994","https://openalex.org/W2085162251","https://openalex.org/W2086409927","https://openalex.org/W2087105697","https://openalex.org/W2088861631","https://openalex.org/W2089007506","https://openalex.org/W2090442630","https://openalex.org/W2090894350","https://openalex.org/W2091592969","https://openalex.org/W2096336546","https://openalex.org/W2097040145","https://openalex.org/W2098031206","https://openalex.org/W2098101490","https://openalex.org/W2100007440","https://openalex.org/W2100595735","https://openalex.org/W2102378371","https://openalex.org/W2103341573","https://openalex.org/W2107277218","https://openalex.org/W2107518823","https://openalex.org/W2110270825","https://openalex.org/W2110710859","https://openalex.org/W2111620983","https://openalex.org/W2113788146","https://openalex.org/W2115238938","https://openalex.org/W2116091611","https://openalex.org/W2120572580","https://openalex.org/W2120978112","https://openalex.org/W2122176343","https://openalex.org/W2123417239","https://openalex.org/W2126039851","https://openalex.org/W2127032203","https://openalex.org/W2127154429","https://openalex.org/W2127810076","https://openalex.org/W2128077735","https://openalex.org/W2128913650","https://openalex.org/W2129596232","https://openalex.org/W2129955536","https://openalex.org/W2131882767","https://openalex.org/W2132099989","https://openalex.org/W2133713832","https://openalex.org/W2135190897","https://openalex.org/W2136113015","https://openalex.org/W2136281115","https://openalex.org/W2138502126","https://openalex.org/W2140489687","https://openalex.org/W2142285934","https://openalex.org/W2143313571","https://openalex.org/W2143630616","https://openalex.org/W2145110767","https://openalex.org/W2146408106","https://openalex.org/W2146940742","https://openalex.org/W2148245148","https://openalex.org/W2148993566","https://openalex.org/W2149832954","https://openalex.org/W2153626991","https://openalex.org/W2155686896","https://openalex.org/W2156641994","https://openalex.org/W2158518759","https://openalex.org/W2160213747","https://openalex.org/W2163220652","https://openalex.org/W2164508226","https://openalex.org/W2164540928","https://openalex.org/W2167045574","https://openalex.org/W2167731943","https://openalex.org/W2168112405","https://openalex.org/W2168299716","https://openalex.org/W2169628503","https://openalex.org/W2169713067","https://openalex.org/W2171151964","https://openalex.org/W2171243928","https://openalex.org/W2172011106","https://openalex.org/W2182386412","https://openalex.org/W2203014519","https://openalex.org/W2272595293","https://openalex.org/W2313701020","https://openalex.org/W2316934507","https://openalex.org/W2405557479","https://openalex.org/W2420040759","https://openalex.org/W2781692874","https://openalex.org/W4251436127"],"related_works":["https://openalex.org/W2122176343","https://openalex.org/W1987980227","https://openalex.org/W2563401420","https://openalex.org/W2602684068","https://openalex.org/W4389026160","https://openalex.org/W1941056073","https://openalex.org/W1143292640","https://openalex.org/W2340426221","https://openalex.org/W2267218330","https://openalex.org/W2955606988"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"contributes":[2],"to":[3,41,159,165,172,196,237,264,274,368,376,427,501,522,539],"nearly":[4],"60,000":[5],"deaths":[6],"per":[7],"year":[8],"in":[9,52,73,193,224,257,288,300,316,320,322,329,342,434,439,460,469,493,504,516],"the":[10,21,68,189,194,292,301,357,371,381,429,470,505,541],"USA":[11],"and":[12,18,35,54,77,106,112,127,138,176,208,212,233,254,278,332,353,396,407,489,534,543],"is":[13,29,60,282,325],"often":[14],"caused":[15],"by":[16,20,32,102],"hypertension":[17],"preceded":[19],"development":[22,302,382,542],"of":[23,57,70,90,104,136,149,183,191,199,205,220,248,252,285,294,303,344,359,373,383,451,472,507,545],"left":[24],"ventricular":[25,82],"hypertrophy":[26,59,459],"(LVH).":[27],"LVH":[28,406,468],"usually":[30],"accompanied":[31],"intensive":[33],"interstitial":[34],"perivascular":[36,64,71,98,174,203,234,250,495,532],"fibrosis":[37,79,235,441],"which":[38,113,227,261,310,498],"may":[39,177,499],"contribute":[40,263,500],"arrhythmogenic":[42],"sudden":[43],"cardiac":[44,58,78,147,430,440,458,524],"death.":[45],"Emerging":[46],"evidence":[47],"indicates":[48],"that":[49,388,399,466,487],"LV":[50,133,266],"dysfunction":[51],"patients":[53],"animal":[55],"models":[56],"closely":[61],"associated":[62],"with":[63,125,144,391],"inflammation.":[65],"To":[66,290],"investigate":[67],"role":[69,247],"inflammation":[72,99,175,260,496,533],"coronary":[74,215],"artery":[75,216],"remodeling":[76,503],"during":[80,334],"hypertrophic":[81,431],"remodeling,":[83],"we":[84,187,305],"used":[85,306],"a":[86,246,312,326,408,517],"well-established":[87],"mouse":[88],"model":[89],"pressure-overload-induced":[91],"LVH:":[92],"transverse":[93],"aortic":[94],"constriction":[95],"(TAC).":[96],"Early":[97],"was":[100,122,152,222,442],"indicated":[101],"accumulation":[103,204,251],"macrophages":[105,126],"T":[107,206,255,349],"lymphocytes":[108,128,207,221,256,490],"24":[109],"hours":[110],"post-TAC":[111],"peaked":[114],"at":[115,129,181,419,444],"day":[116,130],"7.":[117],"Coronary":[118],"luminal":[119],"platelet":[120,455],"deposition":[121],"observed":[123,433,443],"along":[124],"3.":[131],"Also,":[132],"protein":[134],"levels":[135],"VEGF":[137],"MCP-1":[139],"were":[140,366,389],"significantly":[141,229],"increased.":[142],"Consistent":[143],"lymphocyte":[145],"accumulation,":[146],"expression":[148],"IL-10":[150,209],"mRNA":[151,210],"elevated.":[153],"Furthermore,":[154],"circulating":[155],"platelet-leukocyte":[156],"aggregates":[157],"tended":[158],"be":[160],"higher":[161],"after":[162,414],"TAC,":[163],"compared":[164,236],"sham":[166],"controls.":[167],"Platelets":[168],"have":[169,340],"been":[170],"shown":[171],"modulate":[173,275],"facilitate":[178],"leukocyte":[179],"recruitment":[180],"sites":[182],"inflamed":[184],"endothelium.":[185],"Therefore,":[186,337],"investigated":[188],"impact":[190],"thrombocytopenia":[192],"response":[195,412,432],"TAC.":[197,241],"Immunodepletion":[198],"platelets":[200,253,453,488],"decreased":[201],"early":[202,249,413,445,494],"expression,":[211],"altered":[213],"subsequent":[214],"remodeling.":[217,267],"The":[218],"contribution":[219,293],"examined":[223],"Rag1-/-":[225],"mice,":[226,309],"displayed":[228],"more":[230],"intimal":[231],"hyperplasia":[232],"wild-type":[238],"mice":[239,339,365,386,398,425],"following":[240],"Collectively,":[242],"our":[243,484],"studies":[244,485],"support":[245],"pressure":[258,473],"overload-induced":[259],"will":[262],"long-term":[265],"One":[268],"potential":[269],"mechanism":[270],"for":[271],"inflammatory":[272,298],"cells":[273,281,299,375],"their":[276],"environment":[277],"affect":[279],"surrounding":[280],"through":[283],"release":[284,296,538],"cargo":[286,537],"stored":[287],"granules.":[289],"determine":[291,369],"granule":[295,335,378,536],"from":[297,480,511],"LVH,":[304],"Unc13dJinx":[307],"(Jinx)":[308],"contain":[311],"single":[313],"point":[314],"mutation":[315],"Unc13d":[317],"gene":[318],"resulting":[319],"defects":[321,341],"Munc13-4.":[323],"Munc13-4":[324],"limiting":[327],"factor":[328],"vesicular":[330],"priming":[331],"fusion":[333],"secretion.":[336],"Jinx":[338,363,401],"degranulation":[343],"platelets,":[345,515],"NK":[346],"cells,":[347,513],"cytotoxic":[348],"lymphocytes,":[350],"neutrophils,":[351],"mast":[352],"other":[354],"cells.":[355],"With":[356],"use":[358],"bone":[360,393,402],"marrow":[361,394,403],"transplantation,":[362],"chimeric":[364],"created":[367],"whether":[370],"ability":[372],"hematopoietic":[374,512],"secrete":[377],"contents":[379],"affects":[380],"LVH.":[384,508,546],"Wild-type":[385],"(WT)":[387],"transplanted":[390],"WT":[392,397,452],"(WT>WT)":[395],"received":[400],"(Jinx>WT)":[404],"developed":[405],"classic":[409],"fetal":[410],"reprogramming":[411],"TAC":[415],"(7":[416],"days),":[417],"but":[418],"later":[420,502],"times":[421],"(5":[422],"weeks),":[423],"Jinx>WT":[424,461],"failed":[426],"sustain":[428],"WT>WT":[435],"mice.":[436,462],"No":[437],"difference":[438],"or":[446,454],"late":[447],"times.":[448],"Repetitive":[449],"injection":[450],"releasate":[456],"restored":[457],"These":[463,526],"results":[464],"suggest":[465],"sustained":[467],"setting":[471,506],"overload":[474],"depends":[475],"on":[476,530],"factor(s)":[477],"secreted,":[478],"likely":[479],"platelets.":[481],"In":[482],"conclusion,":[483],"demonstrate":[486],"are":[491,520],"involved":[492],"post-TAC,":[497],"Factors":[509],"released":[510],"including":[514],"Munc13-4-dependent":[518],"manner":[519],"required":[521],"promote":[523],"hypertrophy.":[525],"findings":[527],"focus":[528],"attention":[529],"modulating":[531],"targeting":[535],"prevent":[540],"consequences":[544]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
