{"id":"https://openalex.org/W816600312","doi":null,"title":"Role of bivalent cations and choline in ATP-induced apoptosis of human lymphocytes with P2Z receptors.","display_name":"Role of bivalent cations and choline in ATP-induced apoptosis of human lymphocytes with P2Z receptors.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W816600312","mag":"816600312","pmid":"https://pubmed.ncbi.nlm.nih.gov/12899380"},"language":"en","primary_location":{"id":"pmid:12899380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12899380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065769502","display_name":"\u5f6d\u9ece\u660e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P Liming","raw_affiliation_strings":["Department of Laboratory Medicine, First University Hospital, West China University of Medical Sciences, Chengdu 610041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, First University Hospital, West China University of Medical Sciences, Chengdu 610041","institution_ids":["https://openalex.org/I2800091995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073431545","display_name":"JamesSWiley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Wiley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"23","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2z-receptor","display_name":"P2Z receptor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.6150000095367432},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.7440000176429749},{"id":"https://openalex.org/keywords/divalent-cations","display_name":"divalent cations","score":0.921999990940094},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.7749999761581421},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.984000027179718},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endonuclease","display_name":"endonuclease","score":0.7540000081062317},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.8231091499328613},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6285908818244934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6252321004867554},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5423910617828369},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.5031225085258484},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.502265214920044},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.48062509298324585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4247645139694214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36517077684402466},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.35691410303115845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35577207803726196},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.21227619051933289},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12899380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12899380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih","raw_type":"Journal Article"},{"id":"mag:2419664071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12899380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:816600312","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/86798X/199901/8716889.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2369497820","https://openalex.org/W2000875437","https://openalex.org/W2152806530","https://openalex.org/W561548764","https://openalex.org/W2328932307","https://openalex.org/W44963298","https://openalex.org/W1987767066","https://openalex.org/W2107195846","https://openalex.org/W2145664512","https://openalex.org/W2029424042"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,22,44,90,97,136,154],"bivalent":[3,51],"cations":[4],"and":[5,53,81,158,190],"choline":[6],"in":[7,15,41,77,94,146,195,198],"ATP-induced":[8,54,74,91,102,113,155,169,196],"apoptosis":[9,59,197],"via":[10,201],"P2Z":[11,26,144,202],"purinoceptor":[12],"was":[13,85,105,149,172,178],"investigated":[14],"human":[16,147,199],"leukemic":[17,23],"lymphocytes.":[18],"In":[19],"vitro":[20],"exposure":[21],"lymphocytes":[24,200],"with":[25,58],"receptors":[27],"to":[28],"1":[29,46,109],"mmol/L":[30,34,47,110],"ATP":[31,36,142],"or":[32,49,71,99,130],"0.1":[33],"benzoylbenzoic":[35],"(BzATP)":[37],"for":[38,127],"8":[39],"h":[40],"the":[42,82,88,95,159,176,188],"presence":[43],"choline,":[45],"Mg2+":[48,70,129],"other":[50],"cations,":[52],"DNA":[55,75,92,103,114,156,170],"breaks,":[56],"associated":[57],"were":[60,116,125,161],"quantified":[61],"by":[62,87,108,119,141,163],"TdT":[63],"assay.":[64],"We":[65],"observed":[66],"that":[67,187],"(1)":[68],"Extracellular":[69],"Ca2+":[72],"stimulated":[73,140],"fragmentation":[76,93,104,171],"a":[78,151],"dose-dependent":[79],"manner,":[80],"compatible":[83],"evidence":[84],"provided":[86],"inhibition":[89],"present":[96],"EGTA":[98],"EDTA;":[100],"(2)":[101],"completely":[106,173],"inhibited":[107],"Zn2+;":[111],"(3)":[112],"breaks":[115],"not":[117],"affected":[118],"Ba2+,":[120],"Sr2+,":[121],"Co2+":[122],"when":[123,175],"they":[124],"substituted":[126],"extracellular":[128],"Ca2+;":[131],"(4)":[132],"Choline,":[133],"an":[134],"inhibitor":[135,153],"phospholipase":[137],"D":[138],"(PLD)":[139],"through":[143],"receptor":[145],"lymphocytes,":[148],"also":[150],"partial":[152],"fragmentation,":[157],"results":[160,185],"confirmed":[162],"flow":[164],"cytometric":[165],"analysis":[166],"(FCA);":[167],"(5)":[168],"obliterated":[174],"temperature":[177],"lower":[179],"than":[180],"10":[181],"degrees":[182],"C.":[183],"These":[184],"suggest":[186],"endonuclease":[189],"PLD":[191],"may":[192],"be":[193],"involved":[194],"receptor.":[203]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
