{"id":"https://openalex.org/W81576027","doi":null,"title":"Investigation into the cellular mechanisms underlying cell sorting by Eph receptors and ephrins","display_name":"Investigation into the cellular mechanisms underlying cell sorting by Eph receptors and ephrins","publication_year":2012,"publication_date":"2012-07-28","ids":{"openalex":"https://openalex.org/W81576027","mag":"81576027"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1353039","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1353039/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038693001","display_name":"RH Morley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"RH Morley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038693001"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eph-receptors","display_name":"Eph receptors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ephrins","display_name":"ephrins","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-sorting","display_name":"cell sorting","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ephb2","display_name":"EphB2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ephrin-b1","display_name":"ephrin-B1","score":0.996999979019165},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p120-catenin","display_name":"p120 catenin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/differential-adhesion-hypothesis","display_name":"differential adhesion hypothesis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-repulsion","display_name":"cell repulsion","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cell-clusters","display_name":"cell clusters","score":0.48399999737739563},{"id":"https://openalex.org/keywords/cell-segregation","display_name":"cell segregation","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.9714562892913818},{"id":"https://openalex.org/C19331615","wikidata":"https://www.wikidata.org/wiki/Q423602","display_name":"Erythropoietin-producing hepatocellular (Eph) receptor","level":4,"score":0.9626315832138062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6982237696647644},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.6446323990821838},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6111807227134705},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.6049485206604004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.538926362991333},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5071144104003906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.505730152130127},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.47539839148521423},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.41602444648742676},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3646131753921509},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29612642526626587},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24024468660354614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16759765148162842},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.08570590615272522},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1353039","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1353039/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:81576027","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1353039/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":223,"referenced_works":["https://openalex.org/W14610057","https://openalex.org/W1502405928","https://openalex.org/W1524233852","https://openalex.org/W1527722265","https://openalex.org/W1539753443","https://openalex.org/W1555563809","https://openalex.org/W1558338432","https://openalex.org/W1559752086","https://openalex.org/W1584018958","https://openalex.org/W1594867935","https://openalex.org/W1828512827","https://openalex.org/W1837219479","https://openalex.org/W1840797541","https://openalex.org/W1873961654","https://openalex.org/W1876419231","https://openalex.org/W1912221395","https://openalex.org/W1923199128","https://openalex.org/W1929372561","https://openalex.org/W1951716404","https://openalex.org/W1963482376","https://openalex.org/W1965063265","https://openalex.org/W1965938570","https://openalex.org/W1966529319","https://openalex.org/W1967385749","https://openalex.org/W1968965656","https://openalex.org/W1971405375","https://openalex.org/W1973466009","https://openalex.org/W1974640915","https://openalex.org/W1975419284","https://openalex.org/W1976053867","https://openalex.org/W1976867481","https://openalex.org/W1977286350","https://openalex.org/W1977455576","https://openalex.org/W1978105135","https://openalex.org/W1978849431","https://openalex.org/W1979366429","https://openalex.org/W1980094138","https://openalex.org/W1980953487","https://openalex.org/W1981184799","https://openalex.org/W1981228379","https://openalex.org/W1981538228","https://openalex.org/W1984755886","https://openalex.org/W1984759958","https://openalex.org/W1985491605","https://openalex.org/W1985656017","https://openalex.org/W1985778136","https://openalex.org/W1985919477","https://openalex.org/W1986175880","https://openalex.org/W1987547578","https://openalex.org/W1988893861","https://openalex.org/W1989170923","https://openalex.org/W1989896581","https://openalex.org/W1992108446","https://openalex.org/W1992187858","https://openalex.org/W1995208961","https://openalex.org/W1995261404","https://openalex.org/W1995444755","https://openalex.org/W1996131261","https://openalex.org/W1997670728","https://openalex.org/W1998215658","https://openalex.org/W1998255137","https://openalex.org/W1998767410","https://openalex.org/W1999630903","https://openalex.org/W2000221061","https://openalex.org/W2001114745","https://openalex.org/W2001363990","https://openalex.org/W2001879388","https://openalex.org/W2002633541","https://openalex.org/W2002988912","https://openalex.org/W2003445625","https://openalex.org/W2004270681","https://openalex.org/W2004464973","https://openalex.org/W2005261405","https://openalex.org/W2006501473","https://openalex.org/W2006624834","https://openalex.org/W2006666611","https://openalex.org/W2007852446","https://openalex.org/W2009416161","https://openalex.org/W2009671568","https://openalex.org/W2011146811","https://openalex.org/W2011441482","https://openalex.org/W2014578093","https://openalex.org/W2015312864","https://openalex.org/W2016701198","https://openalex.org/W2016902990","https://openalex.org/W2017471776","https://openalex.org/W2018207596","https://openalex.org/W2018912455","https://openalex.org/W2021916807","https://openalex.org/W2023618495","https://openalex.org/W2025234475","https://openalex.org/W2026962151","https://openalex.org/W2028293729","https://openalex.org/W2028337591","https://openalex.org/W2029092025","https://openalex.org/W2029830008","https://openalex.org/W2031484321","https://openalex.org/W2031876645","https://openalex.org/W2032419889","https://openalex.org/W2033430552","https://openalex.org/W2034064964","https://openalex.org/W2034977978","https://openalex.org/W2036178151","https://openalex.org/W2037213257","https://openalex.org/W2037295387","https://openalex.org/W2037943855","https://openalex.org/W2038188046","https://openalex.org/W2038894508","https://openalex.org/W2040210675","https://openalex.org/W2040360281","https://openalex.org/W2042963774","https://openalex.org/W2043562994","https://openalex.org/W2045567387","https://openalex.org/W2046151223","https://openalex.org/W2046490342","https://openalex.org/W2046828793","https://openalex.org/W2047813645","https://openalex.org/W2050935187","https://openalex.org/W2052058944","https://openalex.org/W2052453869","https://openalex.org/W2052689894","https://openalex.org/W2054978737","https://openalex.org/W2055614967","https://openalex.org/W2056986410","https://openalex.org/W2057578059","https://openalex.org/W2059277608","https://openalex.org/W2062408585","https://openalex.org/W2062630837","https://openalex.org/W2063997169","https://openalex.org/W2064239827","https://openalex.org/W2064469337","https://openalex.org/W2067526109","https://openalex.org/W2070095514","https://openalex.org/W2070621059","https://openalex.org/W2072325944","https://openalex.org/W2073158583","https://openalex.org/W2074345277","https://openalex.org/W2074798811","https://openalex.org/W2077087646","https://openalex.org/W2078236511","https://openalex.org/W2078415101","https://openalex.org/W2078842676","https://openalex.org/W2078956094","https://openalex.org/W2079347849","https://openalex.org/W2081427703","https://openalex.org/W2081656219","https://openalex.org/W2081748379","https://openalex.org/W2081796461","https://openalex.org/W2082494746","https://openalex.org/W2084361777","https://openalex.org/W2085179400","https://openalex.org/W2085590667","https://openalex.org/W2085923268","https://openalex.org/W2086325493","https://openalex.org/W2089352744","https://openalex.org/W2092845948","https://openalex.org/W2093265249","https://openalex.org/W2095877450","https://openalex.org/W2097970956","https://openalex.org/W2098327185","https://openalex.org/W2098410928","https://openalex.org/W2108342049","https://openalex.org/W2108794386","https://openalex.org/W2109134145","https://openalex.org/W2109664676","https://openalex.org/W2110061827","https://openalex.org/W2110981204","https://openalex.org/W2111761019","https://openalex.org/W2114718608","https://openalex.org/W2114853719","https://openalex.org/W2115654943","https://openalex.org/W2116628576","https://openalex.org/W2117270090","https://openalex.org/W2117403796","https://openalex.org/W2118263188","https://openalex.org/W2119401631","https://openalex.org/W2119486893","https://openalex.org/W2119726970","https://openalex.org/W2122587655","https://openalex.org/W2122877719","https://openalex.org/W2123129088","https://openalex.org/W2125862744","https://openalex.org/W2125863383","https://openalex.org/W2126348300","https://openalex.org/W2126548263","https://openalex.org/W2129464501","https://openalex.org/W2131384342","https://openalex.org/W2131865548","https://openalex.org/W2131982123","https://openalex.org/W2135482336","https://openalex.org/W2137525036","https://openalex.org/W2139499202","https://openalex.org/W2139676627","https://openalex.org/W2142309916","https://openalex.org/W2143515000","https://openalex.org/W2145273309","https://openalex.org/W2146335969","https://openalex.org/W2148934768","https://openalex.org/W2149605222","https://openalex.org/W2152695708","https://openalex.org/W2153079609","https://openalex.org/W2154046995","https://openalex.org/W2156659788","https://openalex.org/W2157609395","https://openalex.org/W2159870289","https://openalex.org/W2160979115","https://openalex.org/W2162038781","https://openalex.org/W2163740123","https://openalex.org/W2166611044","https://openalex.org/W2169318944","https://openalex.org/W2170384246","https://openalex.org/W2171573054","https://openalex.org/W2182028293","https://openalex.org/W2182475970","https://openalex.org/W2266687804","https://openalex.org/W2285450060","https://openalex.org/W2326591651","https://openalex.org/W2343503371","https://openalex.org/W2345668379","https://openalex.org/W2414937023","https://openalex.org/W2438130813","https://openalex.org/W7096379205","https://openalex.org/W7096389801"],"related_works":["https://openalex.org/W2736845755","https://openalex.org/W6977148386","https://openalex.org/W3213747212","https://openalex.org/W88264602","https://openalex.org/W1976053867","https://openalex.org/W1986175880","https://openalex.org/W3006404123","https://openalex.org/W6981560452","https://openalex.org/W2043310620","https://openalex.org/W6910469850"],"abstract_inverted_index":{"The":[0,51,87],"mechanisms":[1,52,95],"that":[2,73,90,104,115,175,191,205,227],"control":[3],"the":[4,9,27,40,44,47,68,79,167,180,194,217,233],"segregation":[5,25,159,168,198],"of":[6,29,34,46,109,129,142,169,186,219,236,260,265,289],"cells":[7,83,170,238],"in":[8,39,84,101,132,150,251,262,283],"developing":[10,48],"embryo":[11],"are":[12,21,58,96,139,154],"essential":[13],"for":[14,23,98,119,157,209,232],"normal":[15],"development.":[16],"Eph":[17,74],"receptors":[18,75],"and":[19,26,76,136,146,162,202,204],"ephrins":[20,77],"responsible":[22,97],"cell":[24,122,158,221,252,271,294],"maintenance":[28],"sharp":[30],"boundaries":[31],"between":[32,82,212],"regions":[33],"cells,":[35,214,243],"such":[36],"as":[37,107],"those":[38],"adult":[41],"intestine":[42],"or":[43,93],"compartments":[45],"vertebrate":[49],"hindbrain.":[50],"through":[53,144],"which":[54,138,215,267],"they":[55],"achieve":[56],"this":[57,110,133],"not":[59,179,230],"well":[60],"understood.":[61],"One":[62],"widely":[63],"discussed":[64],"theory,":[65],"based":[66],"on":[67],"differential":[69,176],"adhesion":[70,81,131,177,211,291],"hypothesis,":[71],"is":[72,89,117,178,193,207,229,256],"influence":[78],"relative":[80],"adjacent":[85],"compartments.":[86],"other":[88],"active":[91],"migratory":[92],"repulsive":[94],"segregation.":[99,295],"Using":[100],"vitro":[102],"assays":[103],"were":[105],"established":[106,148],"part":[108],"project,":[111],"I":[112,189],"have":[113,147],"shown":[114],"N-cadherin":[116,206,228],"required":[118,156,208,231],"EphB2-ephrinB1":[120],"mediated":[121,199,280],"sorting,":[123],"consistent":[124],"with":[125,166,241,285],"an":[126],"important":[127],"role":[128,250,259],"cell-cell":[130,290],"process.":[134],"p120":[135,261],"p0071,":[137],"downstream":[140,185,264],"targets":[141],"signalling":[143],"EphB2":[145,161,201,220,237],"roles":[149],"regulating":[151],"cadherin":[152],"stability,":[153],"also":[155],"by":[160,200],"ephrinB1.":[163],"However,":[164,254],"comparison":[165],"expressing":[171],"different":[172],"cadherins":[173],"suggests":[174],"main":[181,195],"mechanism":[182,196],"driving":[183,197],"sorting":[184],"Eph-ephrins.":[187],"Instead,":[188],"propose":[190],"repulsion":[192,234,263,281],"ephrinB1":[203,242],"general":[210],"all":[213],"stabilises":[216],"formation":[218],"clusters.":[222],"Cell":[223],"behaviour":[224],"analyses":[225],"indicate":[226],"response":[235],"after":[239],"interactions":[240],"although":[244],"it":[245],"does":[246],"play":[247],"a":[248,257,276,286],"contact-dependent":[249],"migration.":[253],"there":[255],"cadherin-independent":[258],"Eph-ephrins,":[266],"could":[268],"contribute":[269],"to":[270,292],"sorting.":[272],"These":[273],"results":[274],"support":[275],"model":[277],"where":[278],"Eph-ephrin":[279],"acts":[282],"combination":[284],"basal":[287],"level":[288],"drive":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}