{"id":"https://openalex.org/W81539916","doi":null,"title":"Electrolyte and morphologic alterations of myocardium in adriamycin-treated rabbits.","display_name":"Electrolyte and morphologic alterations of myocardium in adriamycin-treated rabbits.","publication_year":1974,"publication_date":"1974-12-01","ids":{"openalex":"https://openalex.org/W81539916","mag":"81539916","pmid":"https://pubmed.ncbi.nlm.nih.gov/4432914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910923"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1910923","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910923","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910923","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108564106","display_name":"Harry M. Olson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D M Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054551018","display_name":"David J. Prieur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Prieur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013717446","display_name":"Andre F. LeRoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A F LeRoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088881960","display_name":"Reginald L. Reagan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Reagan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8704,"has_fulltext":false,"cited_by_count":237,"citation_normalized_percentile":{"value":0.91986911,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"3","first_page":"439","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adriamycin-cardiotoxicity","display_name":"adriamycin cardiotoxicity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ventricular-myocardium","display_name":"ventricular myocardium","score":0.8740000128746033},{"id":"https://openalex.org/keywords/myocardial-ultrastructure","display_name":"myocardial ultrastructure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mitochondrial-degeneration","display_name":"mitochondrial degeneration","score":0.625},{"id":"https://openalex.org/keywords/myelin-figures","display_name":"myelin figures","score":0.6230000257492065},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/myocardial-edema","display_name":"myocardial edema","score":0.878000020980835},{"id":"https://openalex.org/keywords/myocytolysis","display_name":"myocytolysis","score":0.968999981880188},{"id":"https://openalex.org/keywords/tissue-electrolytes","display_name":"tissue electrolytes","score":0.6759999990463257},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.859000027179718},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5690000057220459},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.7090498208999634},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5671840906143188},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5501417517662048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5372483730316162},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5075596570968628},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48820286989212036},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.48574239015579224},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.46235713362693787},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.436736524105072},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4232184588909149},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.41788822412490845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40609559416770935}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005612","descriptor_name":"Freeze Drying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006346","descriptor_name":"Heart Septum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1910923","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910923","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:4432914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4432914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.lsu.edu:physics_astronomy_pubs-7128","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/physics_astronomy_pubs/6048","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:physics_astronomy_pubs-7128","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/physics_astronomy_pubs/6048","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"mag:81539916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4432914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1910923","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910923","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W57780008","https://openalex.org/W60748611","https://openalex.org/W180139333","https://openalex.org/W1580444077","https://openalex.org/W1595778460","https://openalex.org/W1596684752","https://openalex.org/W1969478695","https://openalex.org/W1975597438","https://openalex.org/W2000155615","https://openalex.org/W2024841231","https://openalex.org/W2026516892","https://openalex.org/W2053247927","https://openalex.org/W2063662929","https://openalex.org/W2081953811","https://openalex.org/W2111426313","https://openalex.org/W2123184457","https://openalex.org/W2126249768","https://openalex.org/W2151958427","https://openalex.org/W2298774357","https://openalex.org/W2336434026","https://openalex.org/W2402180009","https://openalex.org/W2410502502","https://openalex.org/W2410925814","https://openalex.org/W3154367256"],"related_works":["https://openalex.org/W2411689595","https://openalex.org/W1965606262","https://openalex.org/W2468850926","https://openalex.org/W2133367164","https://openalex.org/W2404158345","https://openalex.org/W1503019013","https://openalex.org/W2414820174","https://openalex.org/W4409139070","https://openalex.org/W2372348916","https://openalex.org/W2396077453"],"abstract_inverted_index":{"Rabbits":[0,20,115,136],"receiving":[1,116],"adriamycin":[2],"(ADR)":[3],"on":[4],"a":[5,113],"chronic":[6,169],"schedule":[7],"developed":[8,22],"significant":[9,128],"histopathologic,":[10],"ultrastructural":[11],"and":[12,40,42,55,91,104,134,150,164,172],"tissue":[13,161],"electrolyte":[14,146],"alterations":[15],"of":[16,25,32,74,112,123,168,179],"the":[17,33,52,177,180],"ventricular":[18,88,131,160],"myocardium.":[19],"that":[21,156],"clinicopathologic":[23,121],"evidence":[24,122,167],"cardiomyopathy":[26,83,139],"with":[27,82,137],"ADR":[28,117],"had":[29,84,127,140],"histologic":[30],"lesions":[31],"myocardium,":[34],"including":[35],"perivascular":[36],"fibrosis,":[37],"interstitial":[38],"fibrosis":[39],"edema":[41],"myocytolysis.":[43],"Ultrastructurally,":[44],"large":[45],"vacuoles":[46],"resembling":[47,76],"distended":[48],"sarcoplasmic":[49],"reticulum":[50],"displaced":[51],"contractile":[53],"elements":[54],"mitochondria,":[56],"which":[57],"were":[58,96,108],"diminished":[59],"in":[60,87,130,144,159,176],"number":[61],"within":[62],"affected":[63],"myocytes.":[64],"Frequently,":[65],"mitochondria":[66],"appeared":[67],"as":[68],"electron-dense":[69],"structures":[70],"surrounded":[71],"by":[72],"layers":[73],"membranes":[75],"myelin":[77],"figures.":[78],"In":[79],"addition,":[80],"rabbits":[81],"marked":[85,157],"elevations":[86,129],"Ca,":[89,132],"Na":[90,133],"H(2)O":[92],"concentrations.":[93],"Serum":[94],"electrolytes":[95],"not":[97,119],"significantly":[98,109],"elevated,":[99],"but":[100,118],"lactic":[101],"dehydrogenase":[102],"(LDH)":[103],"creatine":[105],"phosphokinase":[106],"(CPK)":[107],"increased,":[110],"indicative":[111],"cardiomyopathy.":[114,182],"developing":[120],"heart":[124],"failure":[125],"also":[126],"H(2)O.":[135],"no":[138,141],"increases":[142,158],"either":[143],"serum":[145],"concentrations":[147],"or":[148],"CPK":[149],"LDH":[151],"levels.":[152],"These":[153],"studies":[154],"indicate":[155],"Ca":[162],"precede":[163],"accompany":[165],"morphologic":[166],"myocardial":[170],"degeneration":[171],"may":[173],"be":[174],"instrumental":[175],"development":[178],"ADR-induced":[181]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}