{"id":"https://openalex.org/W815272268","doi":null,"title":"Protective Effects Of The Alcohol Dehydrogenase-Adh1b Allele","display_name":"Protective Effects Of The Alcohol Dehydrogenase-Adh1b Allele","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W815272268","mag":"815272268"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1285","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/228","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009553111","display_name":"Neil C. Dodge","orcid":"https://orcid.org/0000-0002-5666-3060","observed_orcids":["https://orcid.org/0000-0002-5666-3060"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Neil C. Dodge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5666-3060","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009553111"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcohol-dehydrogenase","display_name":"alcohol dehydrogenase","score":0.906000018119812},{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.8809999823570251},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.5849999785423279},{"id":"https://openalex.org/keywords/genetic-protection","display_name":"genetic protection","score":0.36000001430511475},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.718999981880188},{"id":"https://openalex.org/keywords/attention-deficits","display_name":"attention deficits","score":0.6949999928474426},{"id":"https://openalex.org/keywords/externalizing-problems","display_name":"externalizing problems","score":0.972000002861023},{"id":"https://openalex.org/keywords/maternal-genotype","display_name":"maternal genotype","score":0.527999997138977},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C96722902","wikidata":"https://www.wikidata.org/wiki/Q17710244","display_name":"ADH1B","level":5,"score":0.9808914661407471},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7160806059837341},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.7002196311950684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4730108082294464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38603514432907104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36595821380615234},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.3123015761375427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2806117534637451},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13764265179634094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08256977796554565},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.08185258507728577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05270802974700928},{"id":"https://openalex.org/C151325109","wikidata":"https://www.wikidata.org/wiki/Q22327132","display_name":"Branched-chain alpha-keto acid dehydrogenase complex","level":4,"score":0.051872819662094116}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1285","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/228","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},{"id":"mag:815272268","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.wayne.edu/oa_theses/228/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1485375677","https://openalex.org/W1509900748","https://openalex.org/W1545782352","https://openalex.org/W1597686096","https://openalex.org/W1763163652","https://openalex.org/W1833413198","https://openalex.org/W1844399153","https://openalex.org/W1967169915","https://openalex.org/W1968632832","https://openalex.org/W1969711617","https://openalex.org/W1970168533","https://openalex.org/W1970519025","https://openalex.org/W1971240786","https://openalex.org/W1974262492","https://openalex.org/W1975066872","https://openalex.org/W1983264519","https://openalex.org/W1989174443","https://openalex.org/W1995888662","https://openalex.org/W2002616593","https://openalex.org/W2003844569","https://openalex.org/W2004642890","https://openalex.org/W2008494160","https://openalex.org/W2010799750","https://openalex.org/W2012521226","https://openalex.org/W2012548084","https://openalex.org/W2013165349","https://openalex.org/W2013901167","https://openalex.org/W2023617636","https://openalex.org/W2024085262","https://openalex.org/W2034250899","https://openalex.org/W2035224247","https://openalex.org/W2035280171","https://openalex.org/W2037099021","https://openalex.org/W2037118669","https://openalex.org/W2044812345","https://openalex.org/W2056430434","https://openalex.org/W2060387098","https://openalex.org/W2072707328","https://openalex.org/W2073576912","https://openalex.org/W2079319011","https://openalex.org/W2081171247","https://openalex.org/W2084923898","https://openalex.org/W2092683244","https://openalex.org/W2099106965","https://openalex.org/W2101322446","https://openalex.org/W2102066463","https://openalex.org/W2102166331","https://openalex.org/W2102392660","https://openalex.org/W2105290373","https://openalex.org/W2107518303","https://openalex.org/W2113445887","https://openalex.org/W2114370241","https://openalex.org/W2132895437","https://openalex.org/W2137869268","https://openalex.org/W2140358578","https://openalex.org/W2141533729","https://openalex.org/W2143384791","https://openalex.org/W2143437800","https://openalex.org/W2148565287","https://openalex.org/W2148911584","https://openalex.org/W2150825798","https://openalex.org/W2153120191","https://openalex.org/W2160109824","https://openalex.org/W2166851046","https://openalex.org/W2168058010","https://openalex.org/W2169071913","https://openalex.org/W2169163460","https://openalex.org/W2169868655","https://openalex.org/W2402091222","https://openalex.org/W2905329871","https://openalex.org/W3041166009","https://openalex.org/W4244260421"],"related_works":["https://openalex.org/W2057253223","https://openalex.org/W2061155733","https://openalex.org/W2905329871","https://openalex.org/W2511232403","https://openalex.org/W1985085461","https://openalex.org/W2169163460","https://openalex.org/W1540344649","https://openalex.org/W4249846103","https://openalex.org/W2020968699","https://openalex.org/W2613739644"],"abstract_inverted_index":{"Alcohol":[0],"dehydrogenase":[1],"is":[2,42,219,305],"a":[3,71,205,293],"critical":[4],"enzyme":[5],"in":[6,20,24,77,96,105,116,139,144,174,185,201,243,253,292],"the":[7,16,50,61,90,93,97,117,121,134,140,145,151,155,202,220,225,229,254,259,269,277,287,296,303],"metabolism":[8,48,245,280],"of":[9,12,63,92,120,133,197,228,256,261,268,281,295],"alcohol.":[10,30],"Expression":[11],"three":[13],"alleles":[14,182],"at":[15,64,190,214],"ADH1B":[17,129],"locus":[18],"results":[19,291],"enzymes":[21],"that":[22,60,224,241,283],"differ":[23],"turnover":[25],"rate":[26],"and":[27,81,112,142,171,239],"affinity":[28],"for":[29,128,154,250],"The":[31,131,195,265],"ADH1B*3":[32,68,94,135,193,199,231,271],"allele,":[33],"which":[34,147,289,302],"appears":[35],"to":[36,39,87,102,177,222,234,258,276,301],"be":[37,103,235,274],"unique":[38],"African":[40,78,156],"Americans,":[41],"associated":[43,166],"with":[44,150,167,179],"more":[45,51,278],"rapid":[46,279],"alcohol":[47,75,163,244,263,282,299],"than":[49],"prevalent":[52],"ADH1B*1":[53,181],"allele.":[54,194],"It":[55],"has":[56],"been":[57,126],"previously":[58],"demonstrated":[59],"presence":[62,91,196],"least":[65,191],"one":[66,192],"maternal":[67,230,270],"allele":[69,95,136,200,232,272],"confers":[70,285],"protective":[72,104,208,226,266],"effect":[73,209,267],"against":[74,210],"teratogenicity":[76],"American":[79,157],"infants":[80],"children.":[82],"This":[83,217],"study":[84,218],"was":[85,165],"conducted":[86],"determine":[88],"whether":[89],"mother":[98],"or":[99],"fetus":[100,304],"continues":[101],"alcohol-exposed":[106],"individuals":[107],"during":[108,237,307],"adolescence.":[109],"186":[110],"adolescents":[111,175],"167":[113],"mothers":[114,141,178,188],"participating":[115],"14-year":[118],"follow-up":[119],"Detroit":[122],"Longitudinal":[123],"Cohort":[124],"had":[125,189],"genotyped":[127],"alleles.":[130],"frequencies":[132],"were":[137],"17.6%":[138],"21.0%":[143],"adolescents,":[146],"are":[148],"consistent":[149],"22%":[152],"expected":[153],"population.":[158],"Confirming":[159],"previous":[160],"studies,":[161],"prenatal":[162],"exposure":[164],"increased":[168],"attention":[169],"problems":[170],"externalizing":[172],"behaviors":[173],"born":[176],"two":[180],"but":[183],"not":[184],"those":[186],"whose":[187],"an":[198],"adolescent":[203],"conveyed":[204],"less":[206],"pronounced":[207],"fetal":[211,262],"alcohol-related":[212],"deficits":[213],"this":[215],"age.":[216],"first":[221],"demonstrate":[223],"effects":[227,260],"continue":[233],"evident":[236],"adolescence":[238],"suggests":[240],"differences":[242,252],"genes":[246],"may":[247,273],"help":[248],"account":[249],"individual":[251],"vulnerability":[255],"offspring":[257],"exposure.":[264],"due":[275],"it":[284],"on":[286],"mother,":[288],"presumably":[290],"reduction":[294],"peak":[297],"blood":[298],"concentration":[300],"exposed":[306],"each":[308],"drinking":[309],"episode.":[310]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}