{"id":"https://openalex.org/W81400928","doi":null,"title":"Accessory cell functions of dendritic cells and macrophages in the thymic T-cell response to Con A.","display_name":"Accessory cell functions of dendritic cells and macrophages in the thymic T-cell response to Con A.","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W81400928","mag":"81400928","pmid":"https://pubmed.ncbi.nlm.nih.gov/3499378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454135"},"language":"en","primary_location":{"id":"pmid:3499378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454135/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103152319","display_name":"Yoshitaka Hirayama","orcid":"https://orcid.org/0000-0002-5024-7453","observed_orcids":["https://orcid.org/0000-0002-5024-7453"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Hirayama","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Inaba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Inaba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071533512","display_name":"Shin Komatsubara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Komatsubara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068559343","display_name":"Jun Kawai","orcid":"https://orcid.org/0000-0002-1289-7666","observed_orcids":["https://orcid.org/0000-0002-1289-7666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kawai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113084839","display_name":"Kanako Naito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Naito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017641271","display_name":"Shin\u2010ichi Muramatsu","orcid":"https://orcid.org/0000-0002-3185-7790","observed_orcids":["https://orcid.org/0000-0002-3185-7790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Muramatsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1463,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.40256196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"3","first_page":"393","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9909999966621399},{"id":"https://openalex.org/keywords/accessory-cell-function","display_name":"accessory cell function","score":0.8569999933242798},{"id":"https://openalex.org/keywords/thymic-t-cells","display_name":"thymic T cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9240000247955322},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lymphocyte-activating-factor","display_name":"lymphocyte-activating factor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/paraformaldehyde-fixation","display_name":"paraformaldehyde fixation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/splenic-dendritic-cells","display_name":"splenic dendritic cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2778723968","wikidata":"https://www.wikidata.org/wiki/Q418566","display_name":"Paraformaldehyde","level":2,"score":0.6741581559181213},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6326239705085754},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6047335863113403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4945482909679413},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.47099703550338745},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47024837136268616},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46006858348846436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44456005096435547},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.44007349014282227},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39752012491226196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3281925320625305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23605242371559143},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19901412725448608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17940935492515564},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17014867067337036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10731920599937439}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3499378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1454135","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454135/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:81400928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3499378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454135","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1454135/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1513763162","https://openalex.org/W1521286109","https://openalex.org/W1533102922","https://openalex.org/W1594996614","https://openalex.org/W1615607304","https://openalex.org/W1900008566","https://openalex.org/W1953241347","https://openalex.org/W1966408842","https://openalex.org/W1985665921","https://openalex.org/W1995194119","https://openalex.org/W2000459644","https://openalex.org/W2004059520","https://openalex.org/W2008637341","https://openalex.org/W2010105075","https://openalex.org/W2035075643","https://openalex.org/W2084093106","https://openalex.org/W2093364751","https://openalex.org/W2106980008","https://openalex.org/W2114639640","https://openalex.org/W2144307446","https://openalex.org/W2144382102","https://openalex.org/W2148671394","https://openalex.org/W2166452818"],"related_works":["https://openalex.org/W2075455699","https://openalex.org/W2429313202","https://openalex.org/W2081252460","https://openalex.org/W125985701","https://openalex.org/W7015055151","https://openalex.org/W1759765222","https://openalex.org/W7099414231","https://openalex.org/W2152001564","https://openalex.org/W2118244047","https://openalex.org/W28119547"],"abstract_inverted_index":{"Accessory":[0],"cell":[1,42,105,146,176],"(A":[2],"cell)":[3],"functions":[4],"of":[5,23,39,62,76,92,99,107,127,134,143],"splenic":[6],"dendritic":[7],"cells":[8,33,57,161],"(DC)":[9],"and":[10,47,121,154,183],"peritoneal":[11],"macrophages":[12],"(M":[13],"phi)":[14],"were":[15,28,83],"investigated":[16],"in":[17,37,72,89,110,138,162],"the":[18,60,73,90,116,144,163,171],"Con":[19,44,54,79,100,167],"A-stimulated":[20],"proliferative":[21],"response":[22,98,165],"thymic":[24],"T":[25,56,102],"cells.":[26,78,103],"DC":[27,153,182],"more":[29],"efficient":[30],"as":[31,159],"A":[32,45,77,104,145,160,175],"than":[34],"M":[35,69,81,87,108,128,155,184],"phi":[36,82,88,109,129,156],"respect":[38],"their":[40],"necessary":[41],"numbers,":[43],"dose":[46],"culture":[48],"period":[49],"required":[50],"for":[51],"optimal":[52],"response.":[53],"A-pulsed":[55,80,101],"proliferated":[58],"with":[59,130],"aid":[61],"lymphocyte":[63],"activating":[64],"factor(s)":[65],"(LAF)":[66],"derived":[67],"from":[68],"phi,":[70],"even":[71],"apparent":[74],"absence":[75],"superior":[84],"to":[85,94,114,118,166,173],"unpulsed":[86],"secretion":[91],"LAF":[93],"induce":[95],"a":[96,140],"high":[97],"activity":[106,177],"different":[111,180],"preparations":[112],"appeared":[113],"parallel":[115],"ability":[117],"secrete":[119],"LAF,":[120],"was":[122],"totally":[123],"abolished":[124],"by":[125],"fixation":[126,133],"paraformaldehyde.":[131],"The":[132],"DC,":[135],"however,":[136],"resulted":[137],"only":[139],"partial":[141],"reduction":[142],"activity.":[147],"These":[148],"results":[149],"argue":[150],"that":[151,170],"both":[152],"can":[157],"serve":[158],"T-cell":[164],"A,":[168],"but":[169],"mechanism":[172],"manifest":[174],"is":[178],"somewhat":[179],"between":[181],"phi.":[185]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}