{"id":"https://openalex.org/W81369347","doi":null,"title":"Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions.","display_name":"Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I: Neoplastic and nonneoplastic lung lesions.","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W81369347","mag":"81369347","pmid":"https://pubmed.ncbi.nlm.nih.gov/7530965"},"language":"en","primary_location":{"id":"pmid:7530965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research report (Health Effects Institute)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004521596","display_name":"Joe L. Mauderly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Mauderly","raw_affiliation_strings":["Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109607854","display_name":"M.B. Snipes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Snipes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109293901","display_name":"Edward B. Barr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E B Barr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080346583","display_name":"Steven A. Belinsky","orcid":"https://orcid.org/0000-0002-1240-2504","observed_orcids":["https://orcid.org/0000-0002-1240-2504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Belinsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112735139","display_name":"James A. Bond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Bond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006095579","display_name":"Antone L. Brooks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Brooks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042065117","display_name":"Iyiin Chang","orcid":"https://orcid.org/0000-0001-8304-1606","observed_orcids":["https://orcid.org/0000-0001-8304-1606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Y Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068962393","display_name":"Yanping Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y S Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736678","display_name":"Nancy A. Gillett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Gillett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090667749","display_name":"W. C. Griffith","orcid":"https://orcid.org/0000-0002-0260-1956","observed_orcids":["https://orcid.org/0000-0002-0260-1956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W C Griffith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0237,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.86474631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":"68 Pt 1","first_page":"1","last_page":"75; discussion 77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diesel-exhaust","display_name":"diesel exhaust","score":0.9850000143051147},{"id":"https://openalex.org/keywords/carbon-black","display_name":"carbon black","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pulmonary-carcinogenesis","display_name":"pulmonary carcinogenesis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7559999823570251},{"id":"https://openalex.org/keywords/chronic-inhalation-exposure","display_name":"chronic inhalation exposure","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hemoglobin-adducts","display_name":"hemoglobin adducts","score":0.7570000290870667},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/particle-clearance","display_name":"particle clearance","score":0.5669999718666077},{"id":"https://openalex.org/keywords/particle-dosimetry","display_name":"particle dosimetry","score":0.890999972820282},{"id":"https://openalex.org/keywords/lung-histopathology","display_name":"lung histopathology","score":0.593999981880188},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-inflammation","display_name":"bronchoalveolar lavage inflammation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/animal-to-human-extrapolation","display_name":"animal-to-human extrapolation","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C3432839","wikidata":"https://www.wikidata.org/wiki/Q336041","display_name":"Diesel exhaust","level":3,"score":0.8427087068557739},{"id":"https://openalex.org/C2775925408","wikidata":"https://www.wikidata.org/wiki/Q13174856","display_name":"Soot","level":3,"score":0.7138075828552246},{"id":"https://openalex.org/C138171918","wikidata":"https://www.wikidata.org/wiki/Q38423","display_name":"Diesel fuel","level":2,"score":0.6065335273742676},{"id":"https://openalex.org/C44038986","wikidata":"https://www.wikidata.org/wiki/Q764245","display_name":"Carbon black","level":3,"score":0.6058780550956726},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5210399031639099},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5119262933731079},{"id":"https://openalex.org/C2780804531","wikidata":"https://www.wikidata.org/wiki/Q174174","display_name":"Diesel engine","level":2,"score":0.5085793733596802},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48734530806541443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47114458680152893},{"id":"https://openalex.org/C129871844","wikidata":"https://www.wikidata.org/wiki/Q1134383","display_name":"Diesel particulate filter","level":3,"score":0.44688504934310913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37555819749832153},{"id":"https://openalex.org/C105923489","wikidata":"https://www.wikidata.org/wiki/Q133235","display_name":"Combustion","level":2,"score":0.3055400848388672},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27266353368759155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2003016471862793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12487003207206726},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08271902799606323},{"id":"https://openalex.org/C176933379","wikidata":"https://www.wikidata.org/wiki/Q131877","display_name":"Natural rubber","level":2,"score":0.0},{"id":"https://openalex.org/C171146098","wikidata":"https://www.wikidata.org/wiki/Q124192","display_name":"Automotive engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000395","descriptor_name":"Air Pollutants, Occupational","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001335","descriptor_name":"Vehicle Emissions","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005742","descriptor_name":"Gasoline","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7530965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research report (Health Effects Institute)","raw_type":"Journal Article"},{"id":"mag:81369347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W25350785","https://openalex.org/W1655441320","https://openalex.org/W1973195696","https://openalex.org/W1990827378","https://openalex.org/W1995101219","https://openalex.org/W2019005258","https://openalex.org/W2039935804","https://openalex.org/W2045832449","https://openalex.org/W2072796605","https://openalex.org/W2086455381","https://openalex.org/W2094536764","https://openalex.org/W2108002489","https://openalex.org/W2134896722","https://openalex.org/W2400173384","https://openalex.org/W2414764176","https://openalex.org/W2419062702","https://openalex.org/W2430962842","https://openalex.org/W2469242186"],"related_works":["https://openalex.org/W4246970514","https://openalex.org/W2079628884","https://openalex.org/W2171967180","https://openalex.org/W7098902238","https://openalex.org/W2245249382","https://openalex.org/W4249073143","https://openalex.org/W1998267895","https://openalex.org/W2077699069","https://openalex.org/W2097739428","https://openalex.org/W376954036"],"abstract_inverted_index":{"This":[0],"study":[1],"compared":[2,151],"the":[3,33,37,43,60,68,71,89,136,139,148,363,369,372,376],"pulmonary":[4,51,142],"carcinogenicities":[5],"and":[6,22,86,98,138,144,167,172,232,248,296,315,320,326,335,368,385],"selected":[7,242],"noncancer":[8],"effects":[9],"produced":[10],"by":[11,226,397],"chronic":[12,339],"exposure":[13,99,292],"of":[14,36,46,59,70,93,133,141,197,213,255,277,291,301,308,338,343,365,371,391],"rats":[15,78,176,344],"at":[16,194,205,209],"high":[17],"rates":[18],"to":[19,29,105,158,160,190,199,216,253,293,327,348,354,361],"diesel":[20,47,54,107,118,200,222,256,278],"exhaust":[21,48,108,119,201,223,257],"carbon":[23,110,203,239,350],"black.":[24],"The":[25,57,131,221,238,388],"comparison":[26],"was":[27,224,241,345],"intended":[28],"provide":[30],"insight":[31],"into":[32,401],"likely":[34],"importance":[35],"mutagenic":[38,124,262],"organic":[39,61,129,267],"compounds":[40],"associated":[41,126,264],"with":[42,121,127,265],"soot":[44,120],"portion":[45],"in":[49,53,66,77,135,147,152,164,275,312,323,375],"inducing":[50],"carcinogenicity":[52,76],"exhaust-exposed":[55],"rats.":[56],"role":[58],"fraction":[62,268],"has":[63],"become":[64],"important":[65],"judging":[67],"usefulness":[69],"substantial":[72],"data":[73],"base":[74],"on":[75,234,382],"for":[79,84,87,117,179,188],"predicting":[80],"lung":[81,137,149,165,295,303,314,392],"cancer":[82],"risk":[83],"humans,":[85],"determining":[88],"most":[90],"appropriate":[91],"method":[92],"extrapolating":[94],"results":[95],"across":[96],"species":[97],"concentrations.":[100],"Rats":[101,280],"were":[102,150,156,177,281,359,395],"exposed":[103,178,347],"chronically":[104],"either":[106],"or":[109,202,208,215,288,353],"black,":[111],"which":[112],"served":[113],"as":[114,219],"a":[115],"surrogate":[116],"much":[122],"reduced":[123],"activity":[125,263],"its":[128,266],"fraction.":[130],"sequestration":[132,370],"particles":[134,352,367],"induction":[140],"neoplasia":[143],"non-neoplastic":[145],"changes":[146],"detail.":[153],"Samples":[154],"also":[155,394],"provided":[157,380],"collaborators":[159],"examine":[161,362],"adduct":[162],"formation":[163],"DNA":[166,310],"hemoglobin.":[168],"Approximately":[169],"140":[170,173],"female":[171],"male":[174],"F344/N":[175],"16":[180],"hours":[181],"per":[182,186],"day,":[183],"5":[184],"days":[185],"week":[187],"up":[189],"24":[191],"months,":[192],"beginning":[193],"eight":[195],"weeks":[196],"age,":[198],"black":[204,240,351],"2.5":[206],"mg":[207,211],"6.5":[210],"particles/m3":[212],"air,":[214],"clean":[217],"air":[218],"controls.":[220],"generated":[225],"light-duty":[227],"engines":[228],"burning":[229],"certification":[230],"fuel":[231],"operating":[233],"an":[235],"urban-duty":[236],"cycle.":[237],"because":[243],"it":[244],"had":[245],"particle":[246,386],"size":[247],"surface":[249],"area":[250],"characteristics":[251,390],"similar":[252],"those":[254],"soot,":[258],"but":[259],"markedly":[260],"less":[261],"when":[269],"analyzed":[270],"using":[271],"procedures":[272],"typically":[273],"used":[274],"studies":[276],"soot.":[279],"killed":[282],"after":[283,333],"3,":[284],"6,":[285],"12,":[286],"18,":[287],"23":[289],"months":[290,337],"measure":[294],"lung-associated":[297],"lymph":[298],"node":[299],"burdens":[300],"particles,":[302],"weight,":[304],"bronchoalveolar":[305],"lavage":[306],"indicators":[307],"inflammation,":[309],"adducts":[311],"whole":[313],"alveolar":[316],"type":[317],"II":[318],"cells,":[319],"chromosome":[321],"injury":[322],"circulating":[324],"lymphocytes,":[325],"perform":[328],"histopathologic":[329],"assessment.":[330],"In":[331],"addition,":[332],"3":[334],"18":[336],"exposure,":[340],"one":[341],"group":[342],"acutely":[346],"radiolabeled":[349,366],"fluorescent":[355,373],"microspheres.":[356],"These":[357,378],"exposures":[358],"conducted":[360],"clearance":[364,383],"microspheres":[374],"lungs.":[377],"experiments":[379],"information":[381],"overload":[384],"dosimetry.":[387],"growth":[389],"neoplasms":[393],"examined":[396],"transplanting":[398],"neoplastic":[399],"cells":[400],"athymic":[402],"mice.(ABSTRACT":[403],"TRUNCATED":[404],"AT":[405],"400":[406],"WORDS)":[407]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
