{"id":"https://openalex.org/W81316979","doi":null,"title":"Alterations in nitric oxide production in various forms of circulatory shock.","display_name":"Alterations in nitric oxide production in various forms of circulatory shock.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W81316979","mag":"81316979","pmid":"https://pubmed.ncbi.nlm.nih.gov/7535648"},"language":"en","primary_location":{"id":"pmid:7535648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New horizons (Baltimore, Md.)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108110079","display_name":"Csaba Szab\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C Szab\u00f3","raw_affiliation_strings":["Division of Critical Care, Children's Hospital Medical Center, Cincinnati, OH 45229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care, Children's Hospital Medical Center, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108110079"],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":null,"apc_paid":null,"fwci":15.9674,"has_fulltext":false,"cited_by_count":315,"citation_normalized_percentile":{"value":0.99626527,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"2","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.984000027179718},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.8790000081062317},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.843999981880188},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9580000042915344},{"id":"https://openalex.org/keywords/endotoxin-tolerance","display_name":"endotoxin tolerance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vascular-hyporeactivity","display_name":"vascular hyporeactivity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7417558431625366},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6916967034339905},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6307852864265442},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5376507043838501},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5233670473098755},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.49154457449913025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4549632966518402},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44923123717308044},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4403230845928192},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36636656522750854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34884917736053467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33527517318725586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32805249094963074},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7535648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New horizons (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"mag:81316979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001887083","https://openalex.org/W1980895604","https://openalex.org/W2348632873","https://openalex.org/W2887660577","https://openalex.org/W1983187255","https://openalex.org/W2051488946","https://openalex.org/W1480177379","https://openalex.org/W2058702543","https://openalex.org/W1981406623","https://openalex.org/W2510394580"],"abstract_inverted_index":{"The":[0,106,203],"free":[1],"radical":[2],"nitric":[3],"oxide":[4],"(NO.)":[5],"is":[6,44,96,110,180,210,249,297],"synthesized":[7],"from":[8],"the":[9,24,31,39,74,84,103,113,155,183,233,240,261,290,323,341],"guanidino":[10],"group":[11],"of":[12,17,27,30,41,50,62,87,93,108,115,141,177,191,205,218,232,235,255,268,276,285,292,329,337],"L-arginine":[13],"by":[14,46,81,112,125,215,340],"a":[15,90,188,229],"family":[16],"enzymes":[18],"termed":[19],"NO.":[20,63,338],"synthase":[21],"(NOS).":[22],"In":[23,83],"earlier":[25],"phases":[26],"shock,":[28,43,89,168],"activation":[29,176],"endothelial,":[32],"constitutive":[33],"NOS":[34,94],"(ecNOS)":[35],"occurs,":[36],"which,":[37],"in":[38,65,77,98,102,129,132,135,148,158,161,207,243,270,282],"case":[40],"endotoxic":[42,88,164,167],"triggered":[45],"endotoxin-induced,":[47],"acute":[48,75],"release":[49,114,217],"platelet-activating":[51],"factor":[52],"(PAF)":[53],"and":[54,71,101,123,150,153,187,201,265,294,322],"also":[55,171,288,332],"other":[56],"potential":[57],"mediators.":[58],"This":[59],"early":[60,175,184],"overproduction":[61],"results":[64],"reduced":[66,266],"contractile":[67],"responsiveness":[68],"to":[69,73,137,144,154,173,195,212,222,245,299,301,334],"norepinephrine":[70],"contributes":[72,143,194],"decrease":[76,157],"blood":[78,159],"pressure":[79,160],"afforded":[80],"endotoxin.":[82,126,246],"delayed":[85,145,156,189,196],"phase":[86],"distinct":[91],"isoform":[92],"(iNOS)":[95],"induced":[97],"various":[99,283],"organs":[100],"vessel":[104],"wall.":[105],"induction":[107,190,204,234,267,291],"iNOS":[109,142,192,206,269],"mediated":[111,214],"endogenous":[116,216],"tumor":[117],"necrosis":[118],"factor-alpha":[119],"(TNF-alpha),":[120],"interleukin-1":[121],"(IL-1),":[122],"PAF":[124,314],"These":[127,305],"mediators,":[128],"turn,":[130],"act":[131],"parallel,":[133],"or":[134],"synergy":[136],"induce":[138],"iNOS.":[139],"Induction":[140],"vascular":[146,185],"hyporeactivity":[147],"vivo":[149],"ex":[151],"vivo,":[152],"rats":[162],"with":[163,251],"shock.":[165],"As":[166],"hemorrhagic":[169,208],"shock":[170,209,287,330],"leads":[172],"an":[174,335],"ecNOS,":[178],"which":[179,257],"responsible":[181],"for":[182,260],"hyporeactivity,":[186],"that":[193,278],"circulatory":[197,286],"failure":[198,242],"(vascular":[199],"decompensation":[200],"hyporeactivity).":[202],"unlikely":[211],"be":[213],"endotoxin,":[219],"e.g.,":[220],"due":[221],"intestinal":[223],"ischemia.":[224],"Endogenous":[225],"circulating":[226],"glucocorticoids":[227],"exert":[228,279],"tonic":[230],"suppression":[231],"iNOS,":[236,293],"as":[237,239],"well":[238],"cardiovascular":[241,263],"response":[244,264],"Endotoxin":[247],"tolerance":[248],"associated":[250],"increased":[252],"plasma":[253],"levels":[254],"glucocorticoids,":[256,308],"may":[258],"account":[259],"blunted":[262],"these":[271],"animals.":[272],"A":[273],"wide":[274],"variety":[275],"drugs":[277,306],"protective":[280,303],"effects":[281],"models":[284],"inhibit":[289],"this":[295],"effect":[296],"likely":[298],"contribute":[300],"their":[302],"actions.":[304],"include":[307],"TNF-alpha":[309],"antibodies,":[310],"IL-1":[311],"receptor":[312],"blockers/antibodies,":[313],"antagonists,":[315,318],"dihydropyridine":[316],"calcium-channel":[317],"tyrosine":[319],"kinase":[320],"inhibitors,":[321],"experimental":[324],"drug":[325],"cloricromene.":[326],"Various":[327],"forms":[328],"can":[331],"lead":[333],"inhibition":[336],"production":[339],"calcium-dependent":[342],"ecNOS.(ABSTRACT":[343],"TRUNCATED":[344],"AT":[345],"400":[346],"WORDS)":[347]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}