{"id":"https://openalex.org/W81245076","doi":"https://doi.org/10.1007/978-3-642-23056-1_18","title":"Semi-synthetic Heparinoids","display_name":"Semi-synthetic Heparinoids","publication_year":2011,"publication_date":"2011-12-02","ids":{"openalex":"https://openalex.org/W81245076","doi":"https://doi.org/10.1007/978-3-642-23056-1_18","mag":"81245076","pmid":"https://pubmed.ncbi.nlm.nih.gov/22566235"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-23056-1_18","doi":"https://doi.org/10.1007/978-3-642-23056-1_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-23056-1_18","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W371506833","display_name":"Heparin - A Century of Progress"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019992897","display_name":"Pasqua Oreste","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P. Oreste","raw_affiliation_strings":["Glycores 2000 S.r.l., Milan, Italy. oreste@glycores.it","Glycores 2000 S.r.l., Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycores 2000 S.r.l., Milan, Italy. oreste@glycores.it","institution_ids":[]},{"raw_affiliation_string":"Glycores 2000 S.r.l., Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000563099","display_name":"Giorgio Zoppetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Zoppetti","raw_affiliation_strings":["Glycores 2000 S.r.l., Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycores 2000 S.r.l., Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019992897"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9906,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70599803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":null,"issue":"207","first_page":"403","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.2101999968290329,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glucuronic-acid","display_name":"glucuronic acid","score":0.8100000023841858},{"id":"https://openalex.org/keywords/iduronic-acid","display_name":"iduronic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.984000027179718},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/uronic-acid-content","display_name":"uronic acid content","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2778284416","wikidata":"https://www.wikidata.org/wiki/Q412056","display_name":"Uronic acid","level":3,"score":0.8624802827835083},{"id":"https://openalex.org/C2779650520","wikidata":"https://www.wikidata.org/wiki/Q27895463","display_name":"Iduronic acid","level":4,"score":0.8516930341720581},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.814457356929779},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.7274245619773865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6606961488723755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6479915976524353},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.6380414366722107},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6128929257392883},{"id":"https://openalex.org/C203130289","wikidata":"https://www.wikidata.org/wiki/Q926272","display_name":"Epimer","level":2,"score":0.5742455720901489},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.5523656606674194},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.5212745666503906},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5145787596702576},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5109609961509705},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.4138326644897461},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3474491238594055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08658391237258911}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006496","descriptor_name":"Heparinoids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006496","descriptor_name":"Heparinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-642-23056-1_18","doi":"https://doi.org/10.1007/978-3-642-23056-1_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-23056-1_18","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},{"id":"pmid:22566235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22566235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of experimental pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W1468961","https://openalex.org/W30296868","https://openalex.org/W371506833","https://openalex.org/W614325129","https://openalex.org/W1497283905","https://openalex.org/W1497542892","https://openalex.org/W1505366254","https://openalex.org/W1540551989","https://openalex.org/W1549135486","https://openalex.org/W1554897462","https://openalex.org/W1562621350","https://openalex.org/W1598196431","https://openalex.org/W1599299094","https://openalex.org/W1605457417","https://openalex.org/W1623765232","https://openalex.org/W1636802518","https://openalex.org/W1854803455","https://openalex.org/W1878854037","https://openalex.org/W1904886667","https://openalex.org/W1938067578","https://openalex.org/W1950566269","https://openalex.org/W1967089642","https://openalex.org/W1967933229","https://openalex.org/W1969586202","https://openalex.org/W1972999624","https://openalex.org/W1976109709","https://openalex.org/W1977839571","https://openalex.org/W1991840006","https://openalex.org/W1994310530","https://openalex.org/W1996544895","https://openalex.org/W1997203824","https://openalex.org/W2007519824","https://openalex.org/W2013216622","https://openalex.org/W2015547329","https://openalex.org/W2015901233","https://openalex.org/W2016958521","https://openalex.org/W2024483474","https://openalex.org/W2028915127","https://openalex.org/W2029758640","https://openalex.org/W2036479803","https://openalex.org/W2036555544","https://openalex.org/W2041703901","https://openalex.org/W2041725513","https://openalex.org/W2043046965","https://openalex.org/W2043469852","https://openalex.org/W2045045541","https://openalex.org/W2045877871","https://openalex.org/W2046778136","https://openalex.org/W2046899925","https://openalex.org/W2047416937","https://openalex.org/W2055296721","https://openalex.org/W2056895491","https://openalex.org/W2070340040","https://openalex.org/W2070704281","https://openalex.org/W2071886853","https://openalex.org/W2072111687","https://openalex.org/W2081846517","https://openalex.org/W2081948547","https://openalex.org/W2086889008","https://openalex.org/W2087772385","https://openalex.org/W2089609521","https://openalex.org/W2089784154","https://openalex.org/W2089798738","https://openalex.org/W2093333593","https://openalex.org/W2095323663","https://openalex.org/W2095830444","https://openalex.org/W2100837670","https://openalex.org/W2105723626","https://openalex.org/W2107124774","https://openalex.org/W2109489238","https://openalex.org/W2112939298","https://openalex.org/W2121589151","https://openalex.org/W2124222169","https://openalex.org/W2128572195","https://openalex.org/W2128681927","https://openalex.org/W2144120608","https://openalex.org/W2148745019","https://openalex.org/W2152170709","https://openalex.org/W2167896930","https://openalex.org/W2170601008","https://openalex.org/W2173408616","https://openalex.org/W2182586547","https://openalex.org/W2202279730","https://openalex.org/W2230054475","https://openalex.org/W2237000593","https://openalex.org/W2264744509","https://openalex.org/W2316892465","https://openalex.org/W2326634176","https://openalex.org/W2334330269","https://openalex.org/W3173300771","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2036555544","https://openalex.org/W2121589151","https://openalex.org/W2007831838","https://openalex.org/W2017327429","https://openalex.org/W2093485518","https://openalex.org/W7096443315","https://openalex.org/W1878854037","https://openalex.org/W1605457417","https://openalex.org/W2009634386","https://openalex.org/W2148745019"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}