{"id":"https://openalex.org/W81100607","doi":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","title":"Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP): experimental studies using ITP-prone mice, (NZW x BXSB) F1","display_name":"Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP): experimental studies using ITP-prone mice, (NZW x BXSB) F1","publication_year":1992,"publication_date":"1992-02-15","ids":{"openalex":"https://openalex.org/W81100607","doi":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","mag":"81100607","pmid":"https://pubmed.ncbi.nlm.nih.gov/1737103"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v79.4.942.bloodjournal794942","doi":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Mizutani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Mizutani","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005613597","display_name":"Takayasu Furubayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Furubayashi","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087133884","display_name":"Yoichi Imai","orcid":"https://orcid.org/0000-0002-2938-6133","observed_orcids":["https://orcid.org/0000-0002-2938-6133"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Imai","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041425436","display_name":"Hirokazu Kashiwagi","orcid":"https://orcid.org/0000-0002-4814-8667","observed_orcids":["https://orcid.org/0000-0002-4814-8667"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Kashiwagi","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111772846","display_name":"S. Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Honda","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034604505","display_name":"Hironori Take","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Take","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049500146","display_name":"Y. Kurata","orcid":"https://orcid.org/0000-0001-8333-2032","observed_orcids":["https://orcid.org/0000-0001-8333-2032"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kurata","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Yonezawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Yonezawa","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113985253","display_name":"S Tarui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Tarui","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111597263","display_name":"Susumu Ikehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ikehara","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.6123,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.88492127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"79","issue":"4","first_page":"942","last_page":"947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.9950000047683716},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":1.0},{"id":"https://openalex.org/keywords/platelet-kinetics","display_name":"platelet kinetics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/platelet-survival","display_name":"platelet survival","score":0.875},{"id":"https://openalex.org/keywords/platelet-associated-antibodies","display_name":"platelet-associated antibodies","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.722000002861023},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.5630000233650208},{"id":"https://openalex.org/keywords/platelet-count-increase","display_name":"platelet count increase","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8209210634231567},{"id":"https://openalex.org/C2779771385","wikidata":"https://www.wikidata.org/wiki/Q6132707","display_name":"Thrombocytopenic purpura","level":3,"score":0.7233735918998718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6279599070549011},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6227689981460571},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.5733109712600708},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5512215495109558},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5034319758415222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4976682960987091},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49315446615219116},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.4852978587150574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4106660485267639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34833788871765137},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.2636849284172058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14466023445129395},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v79.4.942.bloodjournal794942","doi":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.4.942.bloodjournal794942","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v79.4.942.942","doi":"https://doi.org/10.1182/blood.v79.4.942.942","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.4.942.942","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1737103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1737103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W73980106","https://openalex.org/W142231282","https://openalex.org/W348221760","https://openalex.org/W1518315072","https://openalex.org/W1596290922","https://openalex.org/W1677082860","https://openalex.org/W1907269084","https://openalex.org/W1963840696","https://openalex.org/W1979820418","https://openalex.org/W2024415071","https://openalex.org/W2031855040","https://openalex.org/W2033613592","https://openalex.org/W2048259741","https://openalex.org/W2058483881","https://openalex.org/W2111245513","https://openalex.org/W2118599141","https://openalex.org/W2120407905","https://openalex.org/W2149186319","https://openalex.org/W2152700768","https://openalex.org/W2160483174","https://openalex.org/W2165835604","https://openalex.org/W2227157639","https://openalex.org/W2317127675","https://openalex.org/W2323819712","https://openalex.org/W2340567530","https://openalex.org/W2400442337","https://openalex.org/W2410581214","https://openalex.org/W2412323113","https://openalex.org/W2418974924","https://openalex.org/W2426481031","https://openalex.org/W3148709400","https://openalex.org/W4231772749"],"related_works":["https://openalex.org/W1518315072","https://openalex.org/W2460492276","https://openalex.org/W1968086694","https://openalex.org/W2090227170","https://openalex.org/W2051726823","https://openalex.org/W1496384569","https://openalex.org/W2588511228","https://openalex.org/W2397081956","https://openalex.org/W2979669101","https://openalex.org/W2065425825"],"abstract_inverted_index":{"To":[0,163],"determine":[1],"the":[2,20,151,165,170,211],"mechanism":[3],"by":[4,237,245],"which":[5],"platelet":[6,21,37,82,112,233],"counts":[7,38,234],"increase":[8,35,65,110],"after":[9,58],"corticosteroid":[10],"therapy":[11],"for":[12],"human":[13],"immune":[14],"thrombocytopenic":[15],"purpura":[16],"(ITP),":[17],"we":[18,178],"studied":[19,179],"kinetics":[22],"using":[23],"prednisolone":[24],"(PDN)-treated":[25],"ITP-prone":[26],"mice,":[27,122,155,177],"(NZW":[28],"x":[29,54],"BXSB)":[30],"F1":[31,43,70,90,121,154,161,176,189],"(W/B":[32],"F1).":[33],"An":[34],"in":[36,41,67,87,98,111,118,126,150,158,174,180],"was":[39,116],"observed":[40,86],"W/B":[42,69,89,120,153,160,175,188],"mice":[44,71,91,190],"(n":[45,72],"=":[46,73],"10,":[47],"mean":[48],"+/-":[49,52,75,93,102],"SD,":[50],"1,202":[51],"202":[53],"10(3)/microL)":[55],"4":[56],"weeks":[57],"treatment":[59],"with":[60,192],"PDN":[61,168,193,206,231],"(2":[62],"mg/kg/d);":[63],"no":[64],"occurred":[66],"nontreated":[68,99,159],"5,651":[74],"126,":[76],"P":[77,105],"less":[78,106],"than":[79,107],".005).":[80],"Prolonged":[81],"life-spans":[83],"(PLSs)":[84],"were":[85,135],"treated":[88,152,191],"(1.29":[92],"0.40":[94],"days),":[95],"but":[96,123,156,243],"not":[97,157,235],"controls":[100],"(0.60":[101],"0.24":[103],"days,":[104],".01).":[108],"No":[109],"production":[113],"(platelet":[114],"turnover)":[115],"found":[117],"PDN-treated":[119],"significant":[124],"decreases":[125],"platelet-associated":[127],"antibodies":[128,133],"(PAAs)":[129],"and":[130,223],"platelet-bindable":[131],"serum":[132],"(PBAs)":[134],"noted.":[136],"Studies":[137],"on":[138,169,210],"organ":[139],"localization":[140],"of":[141,167,183,198,213,227],"radiolabeled":[142],"platelets":[143],"showed":[144,194],"that":[145,230],"hepatic":[146,216],"uptake":[147],"significantly":[148],"decreased":[149],"mice.":[162],"elucidate":[164],"effect":[166,209],"reticulo-endothelial":[171,240],"phagocytic":[172,241],"activity":[173],"vivo":[181],"clearance":[182],"IgG-sensitized,":[184],"51Cr-labeled":[185],"autologous":[186],"erythrocytes.":[187],"a":[195],"marked":[196],"impairment":[197],"their":[199],"ability":[200],"to":[201],"clear":[202],"these":[203],"cells,":[204],"although":[205],"had":[207],"little":[208],"number":[212],"splenic":[214],"or":[215],"macrophage":[217],"Fc":[218],"gamma":[219],"receptors.":[220],"These":[221],"results":[222],"our":[224],"previous":[225],"findings":[226],"splenectomy":[228],"suggest":[229],"improves":[232],"only":[236],"suppressing":[238],"systemic":[239],"function":[242],"also":[244],"reducing":[246],"antibody":[247],"production.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}