{"id":"https://openalex.org/W81046407","doi":null,"title":"Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation.","display_name":"Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation.","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W81046407","mag":"81046407","pmid":"https://pubmed.ncbi.nlm.nih.gov/15134365"},"language":"en","primary_location":{"id":"pmid:15134365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15134365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050607243","display_name":"David E Bentzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E Bentzel","raw_affiliation_strings":["Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054319378","display_name":"Thomas B. Elliott","orcid":"https://orcid.org/0000-0001-8043-6514","observed_orcids":["https://orcid.org/0000-0001-8043-6514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas B Elliott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006772633","display_name":"Christopher E Keller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher E Keller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072351755","display_name":"Itzhak Brook","orcid":"https://orcid.org/0000-0001-6068-1475","observed_orcids":["https://orcid.org/0000-0001-6068-1475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Itzhak Brook","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010261019","display_name":"Michael O. Shoemaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael O Shoemaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011092112","display_name":"Gregory B. Knudson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory B Knudson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.415,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59514436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"54","issue":"2","first_page":"185","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.531000018119812},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sublethal-irradiation","display_name":"sublethal irradiation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antimicrobial-therapy","display_name":"antimicrobial therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gatifloxacin","display_name":"gatifloxacin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hospital-acquired-pneumonia","display_name":"nosocomial pneumonia","score":0.734000027179718},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6050000190734863},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2776520383","wikidata":"https://www.wikidata.org/wiki/Q421713","display_name":"Ceftriaxone","level":3,"score":0.9054901599884033},{"id":"https://openalex.org/C2777653605","wikidata":"https://www.wikidata.org/wiki/Q2365016","display_name":"Gatifloxacin","level":4,"score":0.7825459241867065},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.7825359106063843},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.7705275416374207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7461597919464111},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6568588018417358},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5932410955429077},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5514718294143677},{"id":"https://openalex.org/C2776933286","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumonia","level":4,"score":0.49386531114578247},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.48067721724510193},{"id":"https://openalex.org/C2776102371","wikidata":"https://www.wikidata.org/wiki/Q460030","display_name":"Community-acquired pneumonia","level":3,"score":0.4231227934360504},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39637207984924316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763061463832855},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.36033186316490173},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.2099289894104004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1590169370174408},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.128115713596344},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.08205726742744446},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.07073283195495605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077734","descriptor_name":"Gatifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15134365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15134365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},{"id":"mag:81046407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15134365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2339905819","https://openalex.org/W2169584016","https://openalex.org/W346189994","https://openalex.org/W2399532611","https://openalex.org/W4288061620","https://openalex.org/W2047026101","https://openalex.org/W2413310952","https://openalex.org/W1959272100","https://openalex.org/W1981878806","https://openalex.org/W2443070934"],"abstract_inverted_index":{"Klebsiella":[0,20],"pneumoniae":[1,21,131],"is":[2],"a":[3,16,55,134],"common":[4],"cause":[5],"of":[6,42,47,72,101,123],"nosocomially":[7],"acquired":[8],"pneumonia":[9,17,132],"in":[10,22,65],"immunocompromised":[11,114],"patients.":[12],"Previously,":[13],"we":[14,39],"established":[15],"model":[18],"using":[19,133],"B6D2F1/J":[23],"mice":[24,43,73],"sublethally":[25],"irradiated":[26],"with":[27,50,78,137],"7-Gy":[28],"60Co":[29],"gamma-radiation":[30],"and":[31,54,87],"inoculated":[32],"intratracheally.":[33],"In":[34,96],"the":[35,79,102,108,119],"study":[36],"reported":[37],"here,":[38],"investigated":[40],"survival":[41,71,91],"following":[44],"10":[45],"days":[46],"antimicrobial":[48],"therapy":[49],"ceftriaxone,":[51],"gentamicin,":[52],"gatifloxacin,":[53],"ceftriaxone-gentamicin":[56,80],"combination":[57,81],"given":[58],"once":[59],"daily.":[60],"Survival":[61],"was":[62,74,94],"significantly":[63],"prolonged":[64],"response":[66],"to":[67,99],"all":[68],"therapies.":[69],"However,":[70],"95%":[75],"when":[76],"treated":[77],"followed":[82],"by":[83],"ceftriaxone":[84],"alone":[85],"(75%),":[86],"gatifloxacin":[88],"(80%),":[89],"whereas":[90],"for":[92,127],"controls":[93],"0%.":[95],"addition,":[97],"resistance":[98],"any":[100],"treatments":[103],"did":[104],"not":[105,117],"develop":[106],"during":[107],"study.":[109],"We":[110],"conclude":[111],"that":[112],"an":[113,140],"status":[115],"does":[116],"alter":[118],"Infectious":[120],"Disease":[121],"Society":[122],"America's":[124],"primary":[125],"recommendation":[126],"treating":[128],"community-acquired":[129],"K.":[130],"third-generation":[135],"cephalosporin,":[136],"or":[138],"without":[139],"aminoglycoside.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
