{"id":"https://openalex.org/W810261846","doi":null,"title":"Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems","display_name":"Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W810261846","mag":"810261846"},"language":"en","primary_location":{"id":"pmh:oai:scholarsarchive.byu.edu:etd-4747","doi":null,"is_oa":true,"landing_page_url":"https://scholarsarchive.byu.edu/etd/3748","pdf_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4747&context=etd","source":{"id":"https://openalex.org/S4377196308","display_name":"ScholarsArchive  (Brigham Young University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100005738","host_organization_name":"Brigham Young University","host_organization_lineage":["https://openalex.org/I100005738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4747&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053924613","display_name":"Jonathan Paul Neubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan Paul Neubert","raw_affiliation_strings":["Brigham Young Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham Young Univ","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053924613"],"corresponding_institution_ids":["https://openalex.org/I100005738"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hspb2","display_name":"HSPB2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/small-heat-shock-proteins","display_name":"small heat shock proteins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alphab-crystallin","display_name":"alphaB-crystallin","score":0.843999981880188},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/binding-partners","display_name":"binding partners","score":0.753000020980835},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.9240000247955322},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.5109999775886536},{"id":"https://openalex.org/keywords/mitochondrial-proteins","display_name":"mitochondrial proteins","score":0.734000027179718},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.9570000171661377},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/myosin","display_name":"myosin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/z-line","display_name":"Z-line","score":0.6150000095367432},{"id":"https://openalex.org/keywords/yeast-two-hybrid-screening","display_name":"yeast two-hybrid screening","score":0.7760000228881836},{"id":"https://openalex.org/keywords/coprecipitation","display_name":"co-precipitation","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5475571751594543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3840680718421936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2694709002971649}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarsarchive.byu.edu:etd-4747","doi":null,"is_oa":true,"landing_page_url":"https://scholarsarchive.byu.edu/etd/3748","pdf_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4747&context=etd","source":{"id":"https://openalex.org/S4377196308","display_name":"ScholarsArchive  (Brigham Young University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100005738","host_organization_name":"Brigham Young University","host_organization_lineage":["https://openalex.org/I100005738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"mag:810261846","doi":null,"is_oa":false,"landing_page_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4747&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarsarchive.byu.edu:etd-4747","doi":null,"is_oa":true,"landing_page_url":"https://scholarsarchive.byu.edu/etd/3748","pdf_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4747&context=etd","source":{"id":"https://openalex.org/S4377196308","display_name":"ScholarsArchive  (Brigham Young University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100005738","host_organization_name":"Brigham Young University","host_organization_lineage":["https://openalex.org/I100005738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W810261846.pdf","grobid_xml":"https://content.openalex.org/works/W810261846.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1504005082","https://openalex.org/W1509188373","https://openalex.org/W1527473850","https://openalex.org/W1552105298","https://openalex.org/W1565633801","https://openalex.org/W1568873043","https://openalex.org/W1572688882","https://openalex.org/W1586288730","https://openalex.org/W1588665322","https://openalex.org/W1748644543","https://openalex.org/W1948436988","https://openalex.org/W1965612542","https://openalex.org/W1969271357","https://openalex.org/W1971227936","https://openalex.org/W1972195273","https://openalex.org/W1975712471","https://openalex.org/W1976171313","https://openalex.org/W1977186059","https://openalex.org/W1982669711","https://openalex.org/W1984373476","https://openalex.org/W1984780420","https://openalex.org/W1986908018","https://openalex.org/W1987553698","https://openalex.org/W1988917342","https://openalex.org/W1989308870","https://openalex.org/W1989891419","https://openalex.org/W1990275186","https://openalex.org/W1999030622","https://openalex.org/W2001603814","https://openalex.org/W2002364392","https://openalex.org/W2002433017","https://openalex.org/W2003562213","https://openalex.org/W2006998430","https://openalex.org/W2008985630","https://openalex.org/W2010188733","https://openalex.org/W2015617558","https://openalex.org/W2015731643","https://openalex.org/W2017695062","https://openalex.org/W2018561717","https://openalex.org/W2019094344","https://openalex.org/W2024595785","https://openalex.org/W2025291080","https://openalex.org/W2026735235","https://openalex.org/W2027142237","https://openalex.org/W2027957895","https://openalex.org/W2042562951","https://openalex.org/W2043698693","https://openalex.org/W2047860205","https://openalex.org/W2053666983","https://openalex.org/W2054309404","https://openalex.org/W2054828537","https://openalex.org/W2055043387","https://openalex.org/W2062419041","https://openalex.org/W2062421781","https://openalex.org/W2063317234","https://openalex.org/W2070040696","https://openalex.org/W2073828305","https://openalex.org/W2078748771","https://openalex.org/W2079929278","https://openalex.org/W2092277664","https://openalex.org/W2094065595","https://openalex.org/W2095014501","https://openalex.org/W2109291482","https://openalex.org/W2113710155","https://openalex.org/W2114792019","https://openalex.org/W2117241378","https://openalex.org/W2121622629","https://openalex.org/W2121951891","https://openalex.org/W2127423627","https://openalex.org/W2127812911","https://openalex.org/W2148712661","https://openalex.org/W2150031347","https://openalex.org/W2150164439","https://openalex.org/W2164228620","https://openalex.org/W2169142563","https://openalex.org/W2171183626","https://openalex.org/W2181679132","https://openalex.org/W2217133056","https://openalex.org/W3118710269"],"related_works":["https://openalex.org/W810424356","https://openalex.org/W2194134998","https://openalex.org/W7096615517","https://openalex.org/W7036542885","https://openalex.org/W2017695062","https://openalex.org/W6990903239","https://openalex.org/W1967124825","https://openalex.org/W2159359514","https://openalex.org/W2018308743","https://openalex.org/W2587161773"],"abstract_inverted_index":{"HspB2":[0,66,102,208,247,259],"is":[1,138],"a":[2,23,81],"small":[3,31,231],"heat":[4,32,232],"shock":[5,33,233],"protein":[6,52],"encoded":[7],"on":[8],"human":[9],"chromosome":[10],"11.":[11],"Less":[12],"than":[13],"1000":[14],"base":[15],"pairs":[16],"away":[17],"from":[18],"HSPB2":[19],"and":[20,67,113,200,214,222,236,264],"situated":[21],"in":[22,78,98,127,131,180,248,260],"head-to-head":[24],"orientation":[25],"lies":[26],"the":[27,117,132,147,155,163,167,174,223,243,256],"gene":[28],"encoding":[29],"another":[30,43],"protein,":[34],"CRYAB.":[35],"Because":[36],"they":[37,44,50,58,90],"are":[38,69,169],"uncommonly":[39],"close":[40],"to":[41,72,76,80,88,106,114,116,153,205,207],"one":[42],"share":[45,51],"regulatory":[46],"elements.":[47],"In":[48,86],"addition,":[49],"homology":[53],"as":[54,65,171,173,195,197,212,227,229],"sHSPs,":[55],"suggesting":[56],"that":[57],"perhaps":[59],"perform":[60],"aimilar":[61],"functions.":[62],"SHSPs":[63],"such":[64,210],"CryAB":[68,194],"traditionally":[70],"thought":[71],"provide":[73,252],"protective":[74,108],"effects":[75,109],"cells":[77],"response":[79,87],"variety":[82],"of":[83,100,119,134,149,158,191,220,242,246,258],"stress":[84,89,112],"inducers.":[85],"form":[91],"complexes":[92],"around":[93],"misfolded":[94],"proteins":[95,97,211],"or":[96],"danger":[99],"denaturation.":[101],"has":[103,123],"been":[104,125],"shown":[105],"exhibit":[107],"during":[110],"cellular":[111],"localize":[115],"Z-line":[118],"skeletal":[120],"muscle.":[121],"It":[122],"also":[124,161],"implicated":[126],"cardiac":[128,249,261],"energetics,":[129],"specifically":[130],"production":[133],"ATP,":[135],"however":[136],"little":[137],"known":[139],"about":[140],"its":[141],"molecular":[142,156],"targets.":[143],"Here":[144],"I":[145,160],"report":[146],"use":[148],"yeast":[150],"two-hybrid":[151],"screening":[152],"uncover":[154],"targets":[157],"HspB2.":[159],"detail":[162],"process":[164],"by":[165],"which":[166],"screens":[168],"performed":[170],"well":[172,196,228],"verification":[175],"steps,":[176],"including":[177,193],"co-precipitation":[178],"experiments":[179],"mammalian":[181],"cells.":[182],"Through":[183],"these":[184],"studies":[185],"we":[186],"identify":[187],"many":[188],"novelbinding":[189],"partners":[190,245],"HspB2,":[192],"multiple":[198],"muscle":[199,262],"mitochondrial":[201],"proteins.":[202],"Proteins":[203],"discovered":[204],"bind":[206],"include":[209],"actin":[213],"myosin,":[215],"enzymes":[216],"catalyzing":[217],"various":[218],"steps":[219],"glycolysis":[221],"electron":[224],"transport":[225],"chain,":[226],"redox-,":[230],"protein-,":[234],"kinase-,":[235],"electrolyte-related":[237],"proteins,":[238],"among":[239],"others.":[240],"Studies":[241],"binding":[244],"tissue":[250],"will":[251],"important":[253],"information":[254],"clarifying":[255],"involvement":[257],"maintenance":[263],"metabolism.":[265]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
