{"id":"https://openalex.org/W81010624","doi":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","title":"von Hippel\u2013Lindau (VHL) Protein","display_name":"von Hippel\u2013Lindau (VHL) Protein","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W81010624","doi":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","mag":"81010624"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-378630-2.00333-9","doi":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Biological Chemistry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2564134648","display_name":"Encyclopedia of Biological Chemistry"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054486813","display_name":"Ronald  C. Conaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.C. Conaway","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City,Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City,Missouri, USA","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060208809","display_name":"Joan Weliky Conaway","orcid":"https://orcid.org/0000-0002-2786-0663","observed_orcids":["https://orcid.org/0000-0002-2786-0663"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.W. Conaway","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City,Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City,Missouri, USA","institution_ids":["https://openalex.org/I114131015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114131015"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"570","last_page":"571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-hippel-lindau-protein","display_name":"von Hippel-Lindau protein","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hypoxia-inducible-genes","display_name":"hypoxia-responsive genes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7599999904632568},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/vhl-mutation","display_name":"VHL mutation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/kidney-tumors","display_name":"kidney tumors","score":0.5550000071525574},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endocrine-tumors","display_name":"endocrine tumors","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2778886567","wikidata":"https://www.wikidata.org/wiki/Q741315","display_name":"Von Hippel\u2013Lindau disease","level":3,"score":0.5682691335678101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28200364112854004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23359522223472595},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-378630-2.00333-9","doi":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-378630-2.00333-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Biological Chemistry","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W70776352","https://openalex.org/W1991421091","https://openalex.org/W2017686473","https://openalex.org/W2060254175","https://openalex.org/W2172170481","https://openalex.org/W2596045242"],"related_works":["https://openalex.org/W70776352","https://openalex.org/W2019408347","https://openalex.org/W2790470850","https://openalex.org/W7097451361","https://openalex.org/W2614257677","https://openalex.org/W1558616810","https://openalex.org/W4230725997","https://openalex.org/W2515668698","https://openalex.org/W1994596453","https://openalex.org/W2096547947"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}