{"id":"https://openalex.org/W81005182","doi":"https://doi.org/10.1007/978-3-540-45702-2_11","title":"Molecules that Disrupt Memory Circuits in Alzheimer\u2019s Disease: The Attack on Synapses by A\u03b2 Oligomers (ADDLs)","display_name":"Molecules that Disrupt Memory Circuits in Alzheimer\u2019s Disease: The Attack on Synapses by A\u03b2 Oligomers (ADDLs)","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W81005182","doi":"https://doi.org/10.1007/978-3-540-45702-2_11","mag":"81005182"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-540-45702-2_11","doi":"https://doi.org/10.1007/978-3-540-45702-2_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-540-45702-2_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210183285","display_name":"Research and perspectives in neurosciences","issn_l":"0945-6082","issn":["0945-6082","2196-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Neurosciences","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W586459384","display_name":"Memories: Molecules and Circuits"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054687151","display_name":"William L. Klein","orcid":"https://orcid.org/0000-0002-3047-9978","observed_orcids":["https://orcid.org/0000-0002-3047-9978"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William L. Klein","raw_affiliation_strings":["Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108505001","display_name":"Pascale N. Lacor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascale N. Lacor","raw_affiliation_strings":["Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032823810","display_name":"Fernanda G. De Felice","orcid":"https://orcid.org/0000-0001-8358-0589","observed_orcids":["https://orcid.org/0000-0001-8358-0589"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernanda G. De Felice","raw_affiliation_strings":["Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070851422","display_name":"Sergio Teixeira Ferreira","orcid":"https://orcid.org/0000-0001-7160-9866","observed_orcids":["https://orcid.org/0000-0001-7160-9866"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio T. Ferreira","raw_affiliation_strings":["Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, 2205 Tech Drive, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054687151"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":13.1188,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.97950429,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"155","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.7749999761581421},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.9900000095367432},{"id":"https://openalex.org/keywords/arc","display_name":"Arc","score":0.47699999809265137},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/synaptic-spines","display_name":"synaptic spines","score":0.8059999942779541},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9200000166893005},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.847000002861023},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.6010000109672546},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6039999723434448},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.748779296875},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7428646087646484},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.643028974533081},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.5995661616325378},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5673961639404297},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.535190224647522},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.4918239116668701},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.4703769087791443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4165467619895935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3543117642402649},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32333648204803467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27537328004837036},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2595530152320862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2117023468017578},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.18405747413635254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1355287730693817},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08432036638259888},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.08125406503677368},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-540-45702-2_11","doi":"https://doi.org/10.1007/978-3-540-45702-2_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-540-45702-2_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210183285","display_name":"Research and perspectives in neurosciences","issn_l":"0945-6082","issn":["0945-6082","2196-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Neurosciences","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W173047358","https://openalex.org/W476998514","https://openalex.org/W1493908201","https://openalex.org/W1517772582","https://openalex.org/W1575367484","https://openalex.org/W1584774790","https://openalex.org/W1584834830","https://openalex.org/W1705725530","https://openalex.org/W1798313689","https://openalex.org/W1830690443","https://openalex.org/W1857351893","https://openalex.org/W1964371958","https://openalex.org/W1964741226","https://openalex.org/W1966980297","https://openalex.org/W1967464880","https://openalex.org/W1970164987","https://openalex.org/W1972456354","https://openalex.org/W1979415323","https://openalex.org/W1980750700","https://openalex.org/W1981769842","https://openalex.org/W1982373527","https://openalex.org/W1986295281","https://openalex.org/W1986900475","https://openalex.org/W1988590560","https://openalex.org/W1990179627","https://openalex.org/W1993465897","https://openalex.org/W1993759415","https://openalex.org/W1996995902","https://openalex.org/W1999206064","https://openalex.org/W1999486225","https://openalex.org/W2001900724","https://openalex.org/W2004968757","https://openalex.org/W2009174342","https://openalex.org/W2009556855","https://openalex.org/W2019644389","https://openalex.org/W2020497815","https://openalex.org/W2040721710","https://openalex.org/W2043006474","https://openalex.org/W2044107858","https://openalex.org/W2044564411","https://openalex.org/W2047710949","https://openalex.org/W2055766521","https://openalex.org/W2056126207","https://openalex.org/W2060635494","https://openalex.org/W2060683202","https://openalex.org/W2070881916","https://openalex.org/W2072371192","https://openalex.org/W2075481535","https://openalex.org/W2076551719","https://openalex.org/W2078212921","https://openalex.org/W2084559483","https://openalex.org/W2091612053","https://openalex.org/W2093419961","https://openalex.org/W2096410114","https://openalex.org/W2100610042","https://openalex.org/W2103440561","https://openalex.org/W2107225636","https://openalex.org/W2111920180","https://openalex.org/W2118891894","https://openalex.org/W2121963977","https://openalex.org/W2126108937","https://openalex.org/W2128779293","https://openalex.org/W2131897453","https://openalex.org/W2136901555","https://openalex.org/W2141875125","https://openalex.org/W2142186280","https://openalex.org/W2148256023","https://openalex.org/W2150999725","https://openalex.org/W2158226583","https://openalex.org/W2161532460","https://openalex.org/W2162807572","https://openalex.org/W2165021720","https://openalex.org/W2165160052","https://openalex.org/W2167423431","https://openalex.org/W2167425173","https://openalex.org/W2167720733","https://openalex.org/W2168136532","https://openalex.org/W2168670500","https://openalex.org/W2495970857","https://openalex.org/W4229538079","https://openalex.org/W4250195749"],"related_works":["https://openalex.org/W1973552295","https://openalex.org/W24364968","https://openalex.org/W2090377179","https://openalex.org/W2157069791","https://openalex.org/W2040721710","https://openalex.org/W1993465897","https://openalex.org/W2162807572","https://openalex.org/W1983617141","https://openalex.org/W2088639812","https://openalex.org/W7007828996"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}