{"id":"https://openalex.org/W80973011","doi":null,"title":"Extensive subcutaneous fibrosis in a patient treated with alum precipitated allergenic extract.","display_name":"Extensive subcutaneous fibrosis in a patient treated with alum precipitated allergenic extract.","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W80973011","mag":"80973011","pmid":"https://pubmed.ncbi.nlm.nih.gov/7583869"},"language":"en","primary_location":{"id":"pmid:7583869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7583869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039506772","display_name":"Nicholas A. Orfan","orcid":"https://orcid.org/0009-0000-7227-704X","observed_orcids":["https://orcid.org/0009-0000-7227-704X"]},"institutions":[{"id":"https://openalex.org/I4210155413","display_name":"Bassett Healthcare Network","ror":"https://ror.org/04qvzh720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413"]},{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N A Orfan","raw_affiliation_strings":["Division of Allergy and Immunology, Bassett Healthcare, Cooperstown, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Bassett Healthcare, Cooperstown, New York, USA","institution_ids":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107863552","display_name":"Mark S. Dykewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Dykewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002153642","display_name":"L Barnowsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Barnowsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2806,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77853659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"75","issue":"5","first_page":"453","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.21230000257492065,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.19820000231266022,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-fibrosis","display_name":"subcutaneous fibrosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.859000027179718},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.7559999823570251},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9223794937133789},{"id":"https://openalex.org/C2780924562","wikidata":"https://www.wikidata.org/wiki/Q190527","display_name":"Alum","level":2,"score":0.7724211812019348},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6859527230262756},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5703801512718201},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.5588617324829102},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.556108832359314},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.5434998273849487},{"id":"https://openalex.org/C3018125106","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Injection site","level":2,"score":0.5261910557746887},{"id":"https://openalex.org/C2777300098","wikidata":"https://www.wikidata.org/wiki/Q1164665","display_name":"Subcutaneous tissue","level":2,"score":0.5240169763565063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47124654054641724},{"id":"https://openalex.org/C2994436531","wikidata":"https://www.wikidata.org/wiki/Q949302","display_name":"Skin reaction","level":2,"score":0.4481201171875},{"id":"https://openalex.org/C2993280485","wikidata":"https://www.wikidata.org/wiki/Q5958765","display_name":"Hypersensitivity reaction","level":2,"score":0.42448094487190247},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3827272951602936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20086261630058289},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14346158504486084},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07582816481590271},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7583869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7583869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology","raw_type":"Case Reports"},{"id":"mag:80973011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7583869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092076468","https://openalex.org/W1530334918","https://openalex.org/W2097429268","https://openalex.org/W4239220591","https://openalex.org/W4244551847","https://openalex.org/W1506312791","https://openalex.org/W2185382965","https://openalex.org/W2116642314","https://openalex.org/W2610667423","https://openalex.org/W2416336552"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alum-precipitated":[1,81],"allergenic":[2,82],"extract":[3,83],"(Allpyral)":[4],"used":[5,84],"for":[6,35,85],"immunotherapy":[7,86],"has":[8],"been":[9],"associated":[10,137],"with":[11,41,58,91,138],"subcutaneous":[12,54,89],"nodule":[13],"formation":[14],"at":[15,25,95],"injection":[16],"sites.":[17],"OBJECTIVE:":[18],"We":[19],"describe":[20],"a":[21,116],"severe":[22],"localized":[23],"reaction":[24],"the":[26,96,122],"site":[27,97],"of":[28,98,125],"Allpyral":[29,126],"injections":[30],"and":[31,45,56,72,104],"evaluate":[32],"possible":[33],"mechanisms":[34],"this":[36,139],"reaction.":[37],"METHODS:":[38],"Case":[39],"report":[40],"cutaneous":[42,73],"patch":[43,74],"testing":[44,75],"CAT":[46,67,129],"scan":[47,68,130],"imaging.":[48],"RESULTS:":[49],"The":[50,100],"patient":[51],"developed":[52],"extensive":[53,88],"inflammation":[55],"fibrosis":[57,90],"overlying":[59,92],"skin":[60,93],"changes":[61,94,136],"which":[62],"appear":[63,105],"to":[64,76,106,115,121],"be":[65,107,111],"permanent.":[66,108],"findings":[69],"were":[70],"corroborative":[71],"aluminium":[77],"was":[78,131],"positive.":[79],"CONCLUSIONS:":[80],"caused":[87],"injections.":[99],"lesions":[101],"are":[102],"disfiguring":[103],"This":[109],"may":[110],"due":[112],"in":[113,133],"part":[114],"type":[117],"IV":[118],"hypersensitivity":[119],"response":[120],"aluminum":[123],"component":[124],"extract.":[127],"A":[128],"valuable":[132],"demonstrating":[134],"structural":[135],"lesion.":[140]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}