{"id":"https://openalex.org/W80903083","doi":null,"title":"[Neuropathology of tauopathy].","display_name":"[Neuropathology of tauopathy].","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W80903083","mag":"80903083","pmid":"https://pubmed.ncbi.nlm.nih.gov/24323931"},"language":"ja","primary_location":{"id":"pmid:24323931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24323931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and nerve = Shinkei kenkyu no shinpo","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013784750","display_name":"Mari Yoshida","orcid":"https://orcid.org/0000-0002-8520-6184","observed_orcids":["https://orcid.org/0000-0002-8520-6184"]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mari Yoshida","raw_affiliation_strings":["Institute for Medical Science of Aging, Aichi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Science of Aging, Aichi Medical University","institution_ids":["https://openalex.org/I16528096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013784750"],"corresponding_institution_ids":["https://openalex.org/I16528096"],"apc_list":null,"apc_paid":null,"fwci":0.2406,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.46380361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"65","issue":"12","first_page":"1445","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9599999785423279},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.7200000286102295},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pick-s-disease","display_name":"Pick's disease","score":0.8859999775886536},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corticobasal-degeneration","display_name":"corticobasal degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/argyrophilic-grain-disease","display_name":"argyrophilic grain disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tau-isoforms","display_name":"tau isoforms","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tufted-astrocytes","display_name":"tufted astrocytes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/coiled-bodies","display_name":"coiled bodies","score":0.8349999785423279},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9489612579345703},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.9328953623771667},{"id":"https://openalex.org/C2776936178","wikidata":"https://www.wikidata.org/wiki/Q1755684","display_name":"Corticobasal degeneration","level":4,"score":0.8829517364501953},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.7678056359291077},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6007980704307556},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.5959854125976562},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5616691708564758},{"id":"https://openalex.org/C177738377","wikidata":"https://www.wikidata.org/wiki/Q7683003","display_name":"Tangle","level":2,"score":0.552043080329895},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5272226333618164},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.4796893298625946},{"id":"https://openalex.org/C2777887643","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Pick's disease","level":4,"score":0.46647459268569946},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4224543869495392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4163757264614105},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.39558467268943787},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.39530128240585327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3072549104690552},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24256324768066406},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.23566466569900513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21324467658996582},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.20912420749664307},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.10251155495643616},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020774","descriptor_name":"Pick Disease of the Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020774","descriptor_name":"Pick Disease of the Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24323931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24323931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and nerve = Shinkei kenkyu no shinpo","raw_type":"English Abstract"},{"id":"mag:80903083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24323931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2055932724","https://openalex.org/W1526946111","https://openalex.org/W2044731489","https://openalex.org/W2028570069","https://openalex.org/W4211227716","https://openalex.org/W2229438465","https://openalex.org/W2900486307","https://openalex.org/W4319316995","https://openalex.org/W2035318781","https://openalex.org/W2050922715"],"abstract_inverted_index":{"Microtubules":[0],"are":[1,49,69,108,132,162,190],"key":[2],"cytoskeletal":[3],"elements":[4],"found":[5],"in":[6,20,32,56,110,116,130,148,186],"all":[7],"eukaryotic":[8],"cells.":[9],"Tau":[10],"was":[11,18],"identified":[12,109],"as":[13,23,25,52],"microtubule":[14,21],"associated":[15,44],"protein":[16,68],"and":[17,34,58,97,124,143,147,155,168,183,188],"implicated":[19],"initiation":[22],"well":[24],"assembly.":[26],"Its":[27],"expression":[28,31],"is":[29],"increased":[30],"neurons":[33,57,187],"has":[35],"a":[36],"specific":[37,103],"association":[38],"with":[39,45],"axonal":[40],"microtubules.":[41],"Neurodegenerative":[42],"disorders":[43],"abundant":[46],"tau":[47,67,107,181],"inclusions":[48,55],"collectively":[50],"described":[51],"tauopathies.":[53,73,112],"Pathological":[54],"glial":[59],"cells":[60],"containing":[61],"fibrillary":[62],"aggregates":[63],"of":[64,72,79,106],"abnormally":[65],"hyperphosphorylated":[66],"characteristic":[70],"features":[71,78],"We":[74],"outlined":[75],"the":[76,193],"pathological":[77,173],"major":[80],"tauopathies,":[81],"including":[82],"neurofibrillary":[83],"tangle":[84],"formation":[85],"diseases,":[86],"Pick's":[87],"disease":[88,100,118],"(PiD),":[89],"progressive":[90],"supranuclear":[91],"palsy":[92],"(PSP),":[93],"corticobasal":[94],"degeneration":[95],"(CBD),":[96],"argyrophilic":[98],"grain":[99],"(AGD).":[101],"Disease":[102],"isoform":[104],"compositions":[105],"these":[111],"Neurofibrillary":[113],"tangles":[114],"(NFTs)":[115],"Alzheimer's":[117],"contain":[119,145],"both":[120],"three":[121],"repeat":[122,126],"(3R)-":[123],"four":[125],"(4R)-tau.":[127],"Pick":[128],"bodies":[129,142,154],"PiD":[131],"immunopositive":[133,163],"for":[134,164],"3R-tau.":[135],"In":[136],"PSP":[137,167],"NFTs,":[138],"tufted":[139],"astrocytes,":[140],"coiled":[141,153],"threads":[144,156],"4R-tau":[146],"CBD,":[149],"pretangles,":[150],"astrocytic":[151],"plaques,":[152],"also":[157],"demonstrate":[158],"4R-tau.":[159,165],"Argyrophilic":[160],"grains":[161],"Although":[166],"CBD":[169],"sometimes":[170],"share":[171],"certain":[172],"distribution,":[174],"which":[175],"makes":[176],"clinical":[177],"diagnosis":[178],"difficult,":[179],"cellular":[180],"pathology":[182],"aggregation":[184],"patterns":[185],"glia":[189],"different":[191],"between":[192],"two":[194],"diseases.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}