{"id":"https://openalex.org/W80772303","doi":null,"title":"Effect of Escitalopram on GABA level and anti-oxidant markers in prefrontal cortex and nucleus accumbens of chronic mild stress-exposed albino rats.","display_name":"Effect of Escitalopram on GABA level and anti-oxidant markers in prefrontal cortex and nucleus accumbens of chronic mild stress-exposed albino rats.","publication_year":2009,"publication_date":"2009-06-20","ids":{"openalex":"https://openalex.org/W80772303","mag":"80772303","pmid":"https://pubmed.ncbi.nlm.nih.gov/21383885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047246"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3047246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047246","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101154463","display_name":"Amany Ahmed Shalaby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amany Shalaby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006048580","display_name":"Sahar Mohamed Kamal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sahar Kamal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6999,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.70515111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"2","first_page":"154","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":1.0},{"id":"https://openalex.org/keywords/chronic-mild-stress","display_name":"chronic mild stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9449999928474426},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5830000042915344},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.7350000143051147},{"id":"https://openalex.org/keywords/antioxidant-markers","display_name":"antioxidant biomarkers","score":0.703000009059906},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.8130000233650208},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8880000114440918},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":1.0},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.823806881904602},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.7337259650230408},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.686976969242096},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.612921416759491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47791749238967896},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.47290217876434326},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.46573179960250854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46263283491134644},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.41095712780952454},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4031762182712555},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.40313538908958435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38854801654815674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3752191960811615},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3476789891719818},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2602561414241791},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.22094202041625977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1960754096508026}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3047246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},{"id":"pmid:21383885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21383885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of physiology, pathophysiology and pharmacology","raw_type":"Journal Article"},{"id":"mag:80772303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21383885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3047246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W106814746","https://openalex.org/W1673459884","https://openalex.org/W2416174547"],"related_works":["https://openalex.org/W3180558542","https://openalex.org/W3113602856","https://openalex.org/W2304702067","https://openalex.org/W1763618666","https://openalex.org/W2074602237","https://openalex.org/W4392113075","https://openalex.org/W2034665339","https://openalex.org/W2954601548","https://openalex.org/W2792700527","https://openalex.org/W4388851306"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1,57,62],"is":[2,168],"a":[3,46,143],"critical":[4],"route":[5],"of":[6,32,51,89,100],"damage":[7],"in":[8,39,63,69,83,108,113,121,137,154,161,178,181],"various":[9],"psychological":[10],"stress-induced":[11],"disorders,":[12],"such":[13],"as":[14,104],"depression.":[15],"Antidepressants":[16],"are":[17],"widely":[18],"prescribed":[19],"to":[20,54,59,77,142,146,170,191],"treat":[21],"these":[22,33,84,155],"conditions;":[23],"however,":[24],"few":[25],"animal":[26],"studies":[27],"have":[28,171],"investigated":[29],"the":[30,40,87,131],"effect":[31,173],"drugs":[34],"on":[35],"endogenous":[36],"antioxidant":[37,106,172],"status":[38],"brain.":[41],"The":[42,71,98],"present":[43],"study":[44],"employed":[45],"3":[47],"weeks":[48],"chronic":[49,55],"regimen":[50],"random":[52],"exposure":[53],"mild":[56],"(CMS)":[58],"induce":[60],"oxidative":[61],"brain,":[64],"and":[65,81,151,184],"behavioural":[66],"aberrations":[67],"(anhedonia),":[68],"rats.":[70],"sucrose":[72],"preference":[73],"test":[74],"was":[75,111,119],"used":[76],"identify":[78],"depression-like":[79],"phenotypes,":[80],"reversal":[82],"indices":[85],"indicated":[86],"effectiveness":[88],"treatment":[90],"with":[91,125,175],"escitalopram":[92,128,167],"2.5mg/kg":[93],"daily":[94],"orally":[95],"following":[96],"CMS.":[97,192],"level":[99,144,180],"superoxide":[101],"dismutase":[102],"enzyme(SOD)":[103],"an":[105,176],"markers":[107],"erythrocyte":[109],"lysates":[110],"reduced":[112],"CMS":[114,122],"control":[115,147],"group":[116,123],"while":[117],"it":[118],"elevated":[120],"treated":[124,163],"escitalopram.":[126],"Also":[127],"significantly":[129],"reduce":[130],"thiobarbituric":[132],"acid":[133],"reactive":[134],"substance(TBARS)":[135],"levels":[136,153],"selected":[138],"brain":[139,156],"areas":[140,157],"homogenates":[141,187],"comparable":[145],"group.":[148,164],"Catalase":[149],"activity":[150],"GABA":[152,179],"were":[158],"also":[159],"increase":[160,177],"escitlopram":[162],"In":[165],"conclusion,":[166],"suggested":[169],"associated":[174],"frontal":[182],"cortices":[183],"nucleus":[185],"accumbens":[186],"from":[188],"rats":[189],"exposed":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}