{"id":"https://openalex.org/W8071264","doi":null,"title":"Shared HLA antigens and reproductive performance among Hutterites.","display_name":"Shared HLA antigens and reproductive performance among Hutterites.","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W8071264","mag":"8071264","pmid":"https://pubmed.ncbi.nlm.nih.gov/6577788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1685819"},"language":"en","primary_location":{"id":"pmid:6577788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6577788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104361067","display_name":"Carole L. Ober","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Ober","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036803554","display_name":"Alice O. Martin","orcid":"https://orcid.org/0000-0002-9023-506X","observed_orcids":["https://orcid.org/0000-0002-9023-506X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A O Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080697469","display_name":"Joe Leigh Simpson","orcid":"https://orcid.org/0000-0002-5309-6881","observed_orcids":["https://orcid.org/0000-0002-5309-6881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Simpson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111665353","display_name":"Walter W. Hauck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W W Hauck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109938051","display_name":"D. B. Amos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D B Amos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109242126","display_name":"Donna D. Kostyu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D D Kostyu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029785423","display_name":"M Fotino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fotino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110353014","display_name":"F H Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F H Allen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9072,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.91565368,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"5","first_page":"994","last_page":"1004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-antigens","display_name":"HLA antigens","score":0.8650000095367432},{"id":"https://openalex.org/keywords/histocompatibility","display_name":"histocompatibility","score":0.7929999828338623},{"id":"https://openalex.org/keywords/reproductive-performance","display_name":"reproductive performance","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hutterites","display_name":"Hutterites","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hla-a","display_name":"HLA-A","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hla-b","display_name":"HLA-B","score":1.0},{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.7319999933242798},{"id":"https://openalex.org/keywords/prenatal-selection","display_name":"prenatal selection","score":0.5450000166893005},{"id":"https://openalex.org/keywords/inbred-populations","display_name":"inbred populations","score":0.46299999952316284},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.4580000042915344},{"id":"https://openalex.org/keywords/parity","display_name":"parity","score":0.5509999990463257},{"id":"https://openalex.org/keywords/birth-interval","display_name":"birth interval","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.7439074516296387},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7206621170043945},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7036843299865723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5832833051681519},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.5791805386543274},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5536799430847168},{"id":"https://openalex.org/C117376503","wikidata":"https://www.wikidata.org/wiki/Q751093","display_name":"Reproductive success","level":3,"score":0.5241061449050903},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5061191916465759},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4503074586391449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3956220746040344},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.35751888155937195},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.29171985387802124},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001721","descriptor_name":"Birth Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002835","descriptor_name":"Christianity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003241","descriptor_name":"Consanguinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005328","descriptor_name":"Fetal Viability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6577788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6577788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:8071264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6577788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W84817751","https://openalex.org/W1532781251","https://openalex.org/W1968232306","https://openalex.org/W1972733715","https://openalex.org/W1986908311","https://openalex.org/W2038252730","https://openalex.org/W2130667258","https://openalex.org/W2336575980","https://openalex.org/W2411059801","https://openalex.org/W2429899161"],"related_works":["https://openalex.org/W2166565511","https://openalex.org/W1556049405","https://openalex.org/W159365534","https://openalex.org/W2009273285","https://openalex.org/W2101997979","https://openalex.org/W2090110227","https://openalex.org/W2098349425","https://openalex.org/W2123468478","https://openalex.org/W2201037520","https://openalex.org/W2541394196"],"abstract_inverted_index":{"Shared":[0],"histocompatibility":[1,198],"antigens":[2,47,90,132,226,239,255],"between":[3,140,213],"spouses":[4],"may":[5,30,48,227],"affect":[6],"reproductive":[7,65,93,136,200,211],"outcome":[8,66],"adversely":[9],"as":[10],"a":[11,33,55],"result":[12],"of":[13,40,58,154,197],"prenatal":[14],"selection":[15],"against":[16],"compatible":[17,50],"fetuses.":[18],"Evidence":[19],"from":[20,163],"both":[21],"animal":[22],"and":[23,52,62,107,122,168,245],"human":[24,77],"studies":[25],"suggest":[26],"that":[27,37,79,86,112,146,176,194,215,236,252],"histocompatible":[28],"fetuses":[29,51],"not":[31,69,241],"initiate":[32],"maternal":[34],"immunologic":[35],"response":[36],"prevents":[38],"rejection":[39],"the":[41,73,84,160,184,195],"embryo.":[42],"Therefore,":[43],"parents":[44],"sharing":[45,70,88,237],"HLA":[46,89,238,254],"produce":[49],"consequently":[53],"experience":[54],"greater":[56],"frequency":[57],"early":[59],"fetal":[60,261],"losses":[61],"show":[63],"poorer":[64,92],"than":[67,95,124,149,179,221],"couples":[68,87,96,145,175,214],"antigens.":[71],"In":[72,158],"Hutterites,":[74],"an":[75],"inbred":[76],"isolate":[78],"proscribes":[80],"contraception,":[81],"we":[82],"tested":[83],"hypothesis":[85],"have":[91,228],"outcomes":[94],"who":[97],"do":[98],"not.":[99],"The":[100],"Hutterites":[101],"are":[102,256],"characterized":[103],"by":[104],"high":[105],"fertility":[106],"large":[108],"family":[109],"sizes.":[110],"Couples":[111],"share":[113,147,177,216],"zero":[114],"(no.":[115,119,126],"=":[116,120,127],"21),":[117],"one":[118,125,150,180,222],"15),":[121],"more":[123,148,178,203,220],"10)":[128],"HLA-A":[129,223],"or":[130,219,224],"HLA-B":[131,225],"were":[133,142,171],"compared":[134],"for":[135,259],"performance.":[137],"Median":[138],"intervals":[139,156,162],"births":[141],"larger":[143,173,189],"among":[144,174,183],"antigen":[151],"in":[152,205,210],"eight":[153],"11":[155],"examined.":[157],"addition,":[159],"median":[161],"marriage":[164],"to":[165,187],"first,":[166],"fifth,":[167],"tenth":[169],"birth":[170],"consistently":[172],"antigen.":[181],"Differences":[182],"groups":[185],"appear":[186],"become":[188],"with":[190],"increasing":[191],"parity,":[192],"suggesting":[193],"effect":[196],"on":[199],"performance":[201,212],"becomes":[202],"evident":[204],"later":[206],"pregnancies.":[207],"These":[208],"differences":[209],"zero,":[217],"one,":[218],"significant":[229],"evolutionary":[230],"consequences.":[231],"However,":[232],"our":[233],"results":[234],"demonstrate":[235],"does":[240],"preclude":[242],"normal":[243],"pregnancy":[244],"caution":[246],"should":[247],"be":[248],"exercised":[249],"before":[250],"concluding":[251],"shared":[253],"solely":[257],"responsible":[258],"repeated":[260],"losses.":[262]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}