{"id":"https://openalex.org/W80641983","doi":null,"title":"Analysis of three pigment epithelium-derived factor gene polymorphisms in patients with exudative age-related macular degeneration.","display_name":"Analysis of three pigment epithelium-derived factor gene polymorphisms in patients with exudative age-related macular degeneration.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W80641983","mag":"80641983","pmid":"https://pubmed.ncbi.nlm.nih.gov/19223990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642842"},"language":"en","primary_location":{"id":"pmid:19223990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19223990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2642842/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109873143","display_name":"Dietmar Mattes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Dietmar Mattes","raw_affiliation_strings":["Department of Ophthalmology, Medical University of Graz, Austria. di.mattes@meduni-graz.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Graz, Austria. di.mattes@meduni-graz.at","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029297245","display_name":"Anton Haas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anton Haas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089537116","display_name":"Wilfried Renner","orcid":"https://orcid.org/0000-0002-6199-4382","observed_orcids":["https://orcid.org/0000-0002-6199-4382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfried Renner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030905729","display_name":"Iris Steinbrugger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iris Steinbrugger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063900865","display_name":"Yosuf El\u2010Shabrawi","orcid":"https://orcid.org/0000-0003-1704-0183","observed_orcids":["https://orcid.org/0000-0003-1704-0183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yosuf El-Shabrawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090807814","display_name":"Andreas Wedrich","orcid":"https://orcid.org/0000-0003-2533-7067","observed_orcids":["https://orcid.org/0000-0003-2533-7067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Wedrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Christoph Werner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Werner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038542046","display_name":"O. Schmut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otto Schmut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013901190","display_name":"Martin Weger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Weger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2318,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.85610715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"15","issue":null,"first_page":"343","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9010000228881836},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.8489999771118164},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.7080000042915344},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8090000152587891},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.75}],"concepts":[{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.97026526927948},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8582717180252075},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.6314635872840881},{"id":"https://openalex.org/C204452808","wikidata":"https://www.wikidata.org/wiki/Q7370668","display_name":"Rotterdam Study","level":3,"score":0.5104879140853882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.444520503282547},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4151943027973175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.404265820980072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3823639452457428},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3779491186141968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31044405698776245},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.18607786297798157}],"mesh":[{"descriptor_ui":"D000099174","descriptor_name":"Pigment Epithelium-Derived Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19223990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19223990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2642842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2642842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:80641983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19223990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2642842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2642842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W74870324","https://openalex.org/W164748482","https://openalex.org/W180812339","https://openalex.org/W1484703211","https://openalex.org/W1488341447","https://openalex.org/W1526505338","https://openalex.org/W1882214116","https://openalex.org/W1966374553","https://openalex.org/W1967821317","https://openalex.org/W1975022071","https://openalex.org/W1988077870","https://openalex.org/W1990057691","https://openalex.org/W1993395700","https://openalex.org/W1995006312","https://openalex.org/W1997288094","https://openalex.org/W2011223074","https://openalex.org/W2022084143","https://openalex.org/W2041331503","https://openalex.org/W2043004414","https://openalex.org/W2085238196","https://openalex.org/W2088749707","https://openalex.org/W2091415724","https://openalex.org/W2094719911","https://openalex.org/W2102384125","https://openalex.org/W2105479207","https://openalex.org/W2106901733","https://openalex.org/W2111014976","https://openalex.org/W2113784410","https://openalex.org/W2114733015","https://openalex.org/W2117386992","https://openalex.org/W2120148313","https://openalex.org/W2125236492","https://openalex.org/W2140653050","https://openalex.org/W2158385604","https://openalex.org/W2160429819","https://openalex.org/W2170319465","https://openalex.org/W2418863875","https://openalex.org/W2419306619","https://openalex.org/W2474079320","https://openalex.org/W3145351529"],"related_works":["https://openalex.org/W2074164859","https://openalex.org/W2011223074","https://openalex.org/W2888373059","https://openalex.org/W2114733015","https://openalex.org/W2075682565","https://openalex.org/W2123183824","https://openalex.org/W3018038677","https://openalex.org/W2789838253","https://openalex.org/W1580751347","https://openalex.org/W2159689482"],"abstract_inverted_index":{"PURPOSE:":[0],"Exudative":[1],"age-related":[2],"macular":[3],"degeneration":[4],"(exudative":[5],"AMD)":[6],"is":[7,278],"a":[8,41,65,111,125,195,222,280,288],"common":[9,251],"vision-threatening":[10],"disease,":[11],"with":[12,84,98,137,194,221,242],"both":[13],"environmental":[14],"and":[15,78,118,140,158,168,177,248,252,263],"genetic":[16],"factors":[17],"contributing":[18],"to":[19,109],"its":[20],"development.":[21],"Recently,":[22],"homozygosity":[23],"for":[24,45,284],"the":[25,29,104,119,146,186,209,243,274],"72Met":[26],"variant":[27],"of":[28,55,87,103,121,145,185,199,208,226,273],"pigment":[30],"epithelium-derived":[31],"factor":[32,44,283],"(PEDF)":[33],"Met72Thr":[34,244],"gene":[35,74],"polymorphism":[36,246],"(rs1136287)":[37,245],"was":[38,107,192,219],"identified":[39],"as":[40],"novel":[42],"risk":[43,86,282],"exudative":[46,99,122,138,285],"AMD":[47,123,139,166,261,286],"in":[48,64,124,181,239,287],"Chinese":[49],"patients":[50,97,136,167,262],"from":[51],"Taiwan.":[52],"The":[53,101,130,171],"role":[54],"this":[56],"polymorphism,":[57],"however,":[58],"has":[59],"not":[60,92,162],"yet":[61,93],"been":[62,82,94],"determined":[63,150],"white":[66,126,289],"European":[67,127,290],"population.":[68,128,291],"In":[69],"addition,":[70],"two":[71,172],"other":[72],"PEDF":[73,116,147,156,188,211,276],"polymorphisms,":[75,174],"-5736T>C":[76,175],"(rs12150053)":[77,176],"-5304C>T":[79,178],"(rs12948385),":[80,179],"have":[81,91],"associated":[83,193,220],"increased":[85],"diabetic":[88],"retinopathy,":[89],"but":[90],"studied":[95],"among":[96],"AMD.":[100],"purpose":[102],"present":[105,131],"study":[106,133],"thus":[108],"investigate":[110],"hypothesized":[112],"association":[113],"between":[114,165,260],"these":[115],"polymorphisms":[117,148,237,277],"presence":[120,207],"METHODS:":[129],"case-control":[132],"comprised":[134],"269":[135],"155":[141],"control":[142,169,264],"subjects.":[143,170],"Genotypes":[144],"were":[149,161,180,238,258],"by":[151],"5'-exonuclease":[152],"assays":[153],"(TaqMan).":[154],"RESULTS:":[155],"genotype":[157,191,214,218],"allele":[159],"frequencies":[160,257],"significantly":[163],"different":[164],"promoter":[173,236],"complete":[182],"association.":[183],"Presence":[184],"homozygous":[187,210],"72":[189],"Met/Met":[190],"nonsignificant":[196,223],"odds":[197,224],"ratio":[198,225],"1.00":[200],"(95%":[201,228],"confidence":[202,229],"interval:":[203,230],"0.67-1.49,":[204],"p=0.99).":[205],"Similarly,":[206],"-5736":[212],"TT":[213],"or":[215],"-5304":[216],"CC":[217],"0.99":[227],"0.56":[231],"-":[232],"1.75,":[233],"p=0.97).":[234],"Both":[235],"linkage":[240],"disequilibrium":[241],"(D'=0.83)":[247],"formed":[249],"three":[250],"one":[253],"rare":[254],"haplotype.":[255],"Haplotype":[256],"similar":[259],"subjects":[265],"(p>0.05).":[266],"CONCLUSIONS:":[267],"Our":[268],"data":[269],"suggest":[270],"that":[271],"none":[272],"investigated":[275],"likely":[279],"major":[281]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}