{"id":"https://openalex.org/W806324527","doi":null,"title":"Mechanisms of Bacterial Copper Detoxification and Oxygen Reduction in CueO and Chemotactic Signal Amplification by Receptor Clustering","display_name":"Mechanisms of Bacterial Copper Detoxification and Oxygen Reduction in CueO and Chemotactic Signal Amplification by Receptor Clustering","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W806324527","mag":"806324527"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/194765","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194765","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056347542","display_name":"Satish Kumar Singh","orcid":"https://orcid.org/0000-0003-1991-7727","observed_orcids":["https://orcid.org/0000-0003-1991-7727"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Satish K. Singh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1991-7727","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056347542"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cueo","display_name":"CueO","score":0.9879999756813049},{"id":"https://openalex.org/keywords/multicopper-oxidase","display_name":"multicopper oxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/copper-detoxification","display_name":"copper detoxification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oxygen-reduction-reaction","display_name":"oxygen reduction reaction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8830000162124634},{"id":"https://openalex.org/keywords/reaction-intermediates","display_name":"reaction intermediates","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/receptor-clustering","display_name":"receptor clustering","score":0.8389999866485596},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.515999972820282},{"id":"https://openalex.org/keywords/stopped-flow-kinetics","display_name":"stopped-flow kinetics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/electron-transfer-kinetics","display_name":"electron transfer kinetics","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.6338720321655273},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6162481904029846},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.5730807185173035},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.5492496490478516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5072433352470398},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.44949105381965637},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.43953943252563477},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4336881935596466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3500559329986572},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33030158281326294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31825852394104004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30873769521713257},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19076010584831238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12547829747200012},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10712885856628418},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/194765","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194765","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:806324527","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/bitstream/10150/194765/1/azu_etd_10699_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093238015","https://openalex.org/W2046156129","https://openalex.org/W2626777455","https://openalex.org/W2160326213","https://openalex.org/W4246870838","https://openalex.org/W2113695032","https://openalex.org/W2094702925","https://openalex.org/W2092781147","https://openalex.org/W7127918392","https://openalex.org/W7217270438"],"abstract_inverted_index":{"CueO":[0,68,96,176,235,257,277,318],"is":[1],"a":[2,70,74,102,105,162,201,224,262,272],"multicopper":[3,29,84],"oxidase":[4],"and":[5,14,52,60,73,124,186,229,281,322],"catalyses":[6],"the":[7,36,40,63,119,132,165,179,182,204,210,213,217,227,243,285,306,315,323,328],"four-electron":[8],"reduction":[9,27,156],"of":[10,25,39,48,92,128,135,138,147,169,175,203,212,219,226,234,275,302,317,325],"dioxygen":[11],"to":[12,16,58,117,260,270,295],"water":[13,220],"functions":[15],"protect":[17],"Escherichia":[18],"coli":[19],"against":[20],"copper-induced":[21],"toxicity.":[22],"The":[23,90,144,251,290],"mechanism":[24],"oxygen":[26,155],"in":[28,66,83,87,95,142,208,256,279,288,319],"oxidases":[30,85],"has":[31,69,98],"been":[32,99],"well":[33],"studied,":[34],"but":[35],"key":[37,126],"structures":[38,146,233],"reaction":[41,64,149],"intermediates":[42],"are":[43,151],"not":[44],"known.":[45],"A":[46],"combination":[47],"kinetic":[49,198],"measurements,":[50],"mutagenesis":[51],"X-ray":[53],"crystallographic":[54],"studies":[55,193],"were":[56,159,177,236],"conducted":[57],"entrap":[59],"structurally":[61],"characterize":[62],"states":[65,141,150],"CueO.":[67,143],"methionine-rich":[71,244],"insert":[72],"labile":[75],"copper":[76,88,254,282,303,320],"binding":[77,240],"site,":[78],"two":[79],"features":[80,94,127,168],"found":[81],"only":[82],"involved":[86],"detoxification.":[89],"role":[91,202,316],"these":[93,148],"activity":[97],"investigated.":[100],"In":[101],"separate":[103],"study,":[104],"simple":[106],"mathematical":[107],"model":[108],"based":[109],"on":[110,327],"infectivity":[111],"amongst":[112],"clustered":[113],"receptors":[114],"was":[115,258,268,293],"developed":[116],"explain":[118],"chemotactic":[120],"sensitivity,":[121],"response":[122],"range":[123],"other":[125],"chemotaxis.This":[129],"study":[130],"describes":[131],"successful":[133],"entrapment":[134],"three":[136,170,239],"out":[137],"four":[139],"functional":[140],"crystal":[145,232],"presented.":[152],"Using":[153],"single-turnover":[154],"kinetics":[157],"that":[158],"measured":[160],"using":[161],"stopped-flow":[163],"device,":[164],"optical":[166],"absorption":[167],"different":[171],"fully":[172],"oxidized":[173,184],"forms":[174],"captured:":[178],"native":[180,214],"intermediate,":[181],"resting":[183],"state":[185],"another":[187],"intermediate":[188,215],"lying":[189],"between":[190],"them.":[191],"Stopped-flow":[192],"combined":[194],"with":[195],"electron":[196],"transfer":[197],"measurements":[199],"revealed":[200],"conserved":[205],"residue,":[206],"E506,":[207],"either":[209],"protonation":[211],"or":[216],"release":[218],"molecules":[221],"formed":[222],"as":[223],"product":[225],"reaction.Cu(I)":[228],"Ag(I)":[230,267,300],"bound":[231],"determined":[237],"revealing":[238],"sites":[241],"along":[242],"helix":[245],"used":[246],"by":[247,284,305],"both":[248],"metal":[249],"ions.":[250],"labile,":[252],"regulatory":[253],"site":[255],"shown":[259,269],"be":[261,271,296],"Cu(I)":[263],"susbtrate":[264],"oxidation":[265],"site.":[266],"potent":[273],"inhibitor":[274],"all":[276],"activities":[278],"vitro":[280],"detoxification":[283,304,321,329],"cue":[286,307],"system":[287,292],"vivo.":[289],"cus":[291],"discovered":[294],"necessary":[297],"for":[298],"removing":[299],"inhibition":[301],"system.":[308],"These":[309],"results":[310],"provide":[311],"further":[312],"insights":[313],"into":[314],"effect":[324],"silver":[326],"mechanism.":[330]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
