{"id":"https://openalex.org/W80624533","doi":null,"title":"Endothelial barrier function and Na+/K(+)-ATPase pump density in herpetic stromal disease.","display_name":"Endothelial barrier function and Na+/K(+)-ATPase pump density in herpetic stromal disease.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W80624533","mag":"80624533","pmid":"https://pubmed.ncbi.nlm.nih.gov/8550332"},"language":"en","primary_location":{"id":"pmid:8550332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8550332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"W J O'Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J O'Brien","raw_affiliation_strings":["Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M L Palmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Palmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Guy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Guy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109954847","display_name":"Jerry Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3938,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.60585808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"37","issue":"1","first_page":"29","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.48339998722076416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.48339998722076416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.17499999701976776,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpetic-stromal-keratitis","display_name":"herpetic stromal keratitis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.9459999799728394},{"id":"https://openalex.org/keywords/corneal-endothelium","display_name":"corneal endothelium","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.7670000195503235},{"id":"https://openalex.org/keywords/corneal-hydration","display_name":"corneal hydration","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ouabain-binding","display_name":"ouabain binding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7273103594779968},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.6505236625671387},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.5654777884483337},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.5616609454154968},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.5160843729972839},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.514446496963501},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.47741782665252686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4147990942001343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32618027925491333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3234395980834961},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3069149851799011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2056477665901184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.196550190448761},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1702265441417694},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.13012439012527466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09262287616729736},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08327117562294006},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004728","descriptor_name":"Endothelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004728","descriptor_name":"Endothelium, Corneal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015715","descriptor_name":"Corneal Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015715","descriptor_name":"Corneal Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015715","descriptor_name":"Corneal Edema","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8550332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8550332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:80624533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8550332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G405978938","display_name":"VISION RESEARCH TRAINING","funder_award_id":"5t32ey007016-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4207920608","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY001931","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4605353813","display_name":"CORNEAL FUNCTION IN HERPESVIRUS INDUCED STROMAL DISEASE","funder_award_id":"5r01ey007120-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2258750","https://openalex.org/W9542495","https://openalex.org/W13126823","https://openalex.org/W29506661","https://openalex.org/W73999867","https://openalex.org/W74536404","https://openalex.org/W92698692","https://openalex.org/W98479187","https://openalex.org/W99404935","https://openalex.org/W195882844","https://openalex.org/W203975652","https://openalex.org/W1844420489","https://openalex.org/W1968608567","https://openalex.org/W1971519888","https://openalex.org/W1972528203","https://openalex.org/W1974185050","https://openalex.org/W1978111169","https://openalex.org/W1991328345","https://openalex.org/W1997998362","https://openalex.org/W2000722681","https://openalex.org/W2024494932","https://openalex.org/W2033522791","https://openalex.org/W2052274546","https://openalex.org/W2052485577","https://openalex.org/W2052838077","https://openalex.org/W2072088029","https://openalex.org/W2080834864","https://openalex.org/W2083416343","https://openalex.org/W2083687478","https://openalex.org/W2083781121","https://openalex.org/W2086428886","https://openalex.org/W2093033018","https://openalex.org/W2093700540","https://openalex.org/W2140674121","https://openalex.org/W2147953100","https://openalex.org/W2150415624","https://openalex.org/W2294824445","https://openalex.org/W2987329348"],"related_works":["https://openalex.org/W1978111169","https://openalex.org/W78365937","https://openalex.org/W1973763767","https://openalex.org/W4206663190","https://openalex.org/W99404935","https://openalex.org/W1974185050","https://openalex.org/W2258750","https://openalex.org/W122715865","https://openalex.org/W3124863277","https://openalex.org/W2030914403"],"abstract_inverted_index":{"PURPOSE:":[0],"Corneal":[1],"edema":[2,89,150,176],"is":[3],"a":[4,24,31,164],"significant":[5,166],"component":[6],"of":[7,11,21,26,43,81,97,101,111,147,200,218],"the":[8,41,79,82,98,109,198],"various":[9,104],"forms":[10],"herpes":[12],"simplex":[13],"virus":[14],"type":[15],"1":[16],"(HSV-1)-induced":[17],"stromal":[18,72,115,152,220],"disease.":[19,153],"Maintenance":[20],"corneal":[22,27,67,88,149,201,208],"thickness,":[23],"reflection":[25],"hydration,":[28],"depends":[29],"on":[30],"physical":[32],"barrier":[33,118,210],"formed":[34],"by":[35,40,70,94,160,191],"endothelial":[36,117,132,209],"cell-cell":[37],"junctions":[38],"and":[39,50,112,120,139,151],"activity":[42],"Na+/K(+)-ATPase":[44,121,155],"pumps":[45],"that":[46,207],"regulate":[47],"ion":[48],"flux":[49],"thus":[51],"influence":[52],"water":[53],"movement":[54],"through":[55],"this":[56,216],"cell":[57],"layer.":[58],"These":[59,204],"functions":[60],"were":[61,124,141],"measured":[62,125,159],"in":[63,92,126,171,215],"corneas":[64,173],"with":[65,87,197],"increased":[66],"thickness":[68],"caused":[69],"HSV-1-induced":[71,219],"disease":[73,86],"to":[74,78,178,188],"determine":[75],"their":[76],"contribution":[77],"pathogenesis":[80],"edema.":[83,202],"METHODS:":[84],"Stromal":[85],"was":[90,212,225],"induced":[91],"rabbits":[93],"intrastromal":[95],"injection":[96],"RE":[99],"strain":[100],"HSV-1.":[102],"At":[103],"times":[105],"after":[106,194],"infection,":[107,195],"during":[108,145,174],"development":[110],"recovery":[113],"from":[114],"disease,":[116],"function":[119,211],"pump":[122,156,223],"sites":[123],"excised":[127],"rabbit":[128],"corneas.":[129,184],"RESULTS:":[130],"The":[131],"permeability":[133],"coefficient,":[134],"Ktrans,":[135],"for":[136],"14C-dextran,":[137],"3H-inulin,":[138],"14C-mannitol,":[140],"not":[142,213],"altered":[143,214],"significantly":[144],"periods":[146],"maximal":[148],"Endothelial":[154],"density,":[157],"as":[158],"ouabain":[161],"binding,":[162],"showed":[163],"statistically":[165],"(P":[167],"<":[168],"0.05)":[169],"decrease":[170],"HSV-1-infected":[172],"peak":[175],"compared":[177],"mock":[179],"antigen-injected":[180],"or":[181],"uninjected":[182],"control":[183],"Pump":[185],"density":[186,224],"returned":[187],"baseline":[189],"values":[190],"24":[192],"days":[193],"concurrent":[196],"resolution":[199],"CONCLUSIONS:":[203],"results":[205],"indicate":[206],"form":[217],"edema;":[221],"however,":[222],"reduced":[226],"significantly.":[227]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
