{"id":"https://openalex.org/W80578396","doi":null,"title":"Differential effects of a new central adrenergic agonist--modafinil--and D-amphetamine on sleep and early morning behaviour in young healthy volunteers.","display_name":"Differential effects of a new central adrenergic agonist--modafinil--and D-amphetamine on sleep and early morning behaviour in young healthy volunteers.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W80578396","mag":"80578396","pmid":"https://pubmed.ncbi.nlm.nih.gov/2568348"},"language":"en","primary_location":{"id":"pmid:2568348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2568348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112818820","display_name":"Bernd Saletu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"B Saletu","raw_affiliation_strings":["Department of Psychiatry, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021127724","display_name":"Richard Frey","orcid":"https://orcid.org/0000-0003-1816-6159","observed_orcids":["https://orcid.org/0000-0003-1816-6159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Frey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Krupka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Krupka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006420278","display_name":"P. Anderer","orcid":"https://orcid.org/0000-0002-3869-6678","observed_orcids":["https://orcid.org/0000-0002-3869-6678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Anderer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073473043","display_name":"Josef Gr\u00fcnberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Gr\u00fcnberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111739706","display_name":"M.J. Barbanoj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Barbanoj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0314,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.76064757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"183","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.17080000042915344,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modafinil","display_name":"modafinil","score":1.0},{"id":"https://openalex.org/keywords/d-amphetamine","display_name":"d-amphetamine","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alpha-adrenergic-agonists","display_name":"alpha-adrenergic agonists","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sleep-maintenance","display_name":"sleep maintenance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sleep-efficiency","display_name":"sleep efficiency","score":0.6610000133514404},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.5860000252723694},{"id":"https://openalex.org/keywords/stage-2-sleep","display_name":"stage 2 sleep","score":0.8159999847412109},{"id":"https://openalex.org/keywords/subjective-sleep-quality","display_name":"subjective sleep quality","score":0.7490000128746033},{"id":"https://openalex.org/keywords/critical-flicker-frequency","display_name":"critical flicker frequency","score":0.7459999918937683},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pulse-rate","display_name":"pulse rate","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C2780714222","wikidata":"https://www.wikidata.org/wiki/Q410441","display_name":"Modafinil","level":2,"score":0.9169843196868896},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.7726268768310547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.582683265209198},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5576427578926086},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.5263268351554871},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.5173537135124207},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4779213070869446},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.4712446331977844},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4581626057624817},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.3097994923591614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2486405074596405},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2036617398262024},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.09422782063484192},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077408","descriptor_name":"Modafinil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001519","descriptor_name":"Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004576","descriptor_name":"Electromyography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004585","descriptor_name":"Electrooculography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005425","descriptor_name":"Flicker Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2568348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2568348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology research","raw_type":"Clinical Trial"},{"id":"mag:80578396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2568348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W162529770","https://openalex.org/W2073893366","https://openalex.org/W1993116126","https://openalex.org/W2040590783","https://openalex.org/W2071749684","https://openalex.org/W2419544619","https://openalex.org/W2525566136","https://openalex.org/W2018225738","https://openalex.org/W2105199807","https://openalex.org/W2110785271"],"abstract_inverted_index":{"Modafinil":[0],"(CRL":[1],"40476)":[2],"is":[3],"a":[4,15,93,142,161,205],"recently":[5],"developed":[6],"central":[7],"alpha":[8],"adrenergic":[9],"agonist":[10],"with":[11,40],"vigilance-promoting":[12],"properties.":[13],"In":[14,200],"double-blind,":[16],"placebo-controlled":[17],"sleep":[18,54,119,149,173,182,185,203,208,227],"laboratory":[19],"study,":[20],"its":[21],"single-dose":[22],"effects":[23],"on":[24],"objectively":[25],"and":[26,32,38,67,73,78,103,120,123,136,184,198,211,242,261,289,291,309],"subjectively":[27],"evaluated":[28,140],"sleep,":[29],"morning":[30,34,125,132,246,292],"awakening,":[31],"early":[33,124],"behaviour":[35],"were":[36,85,99,139,256],"investigated":[37],"compared":[39,159,194,283],"amphetamine.":[41],"Ten":[42],"young":[43],"healthy":[44],"volunteers":[45],"of":[46,147,169,207,307,312],"both":[47],"sexes":[48],"spent":[49],"12":[50],"nights":[51,64],"in":[52,87,244],"the":[53,107,131,170,196,236,245,259,262,285,300],"laboratory:":[55],"one":[56,59,88],"adaptation":[57],"night,":[58,61],"baseline":[60],"five":[62,79],"drug":[63,108],"(100":[65],"mg":[66,69,72,75,191,280],"200":[68],"modafinil;":[70],"10":[71],"20":[74,190,279],"d-amphetamine;":[76],"placebo)":[77],"subsequent":[80,129],"washout":[81],"nights.":[82],"The":[83],"drugs":[84,264],"administered":[86],"week":[89],"intervals":[90],"according":[91],"to":[92,130,160,195,202,284,302],"Latin":[94],"square":[95],"design.":[96],"Somnopolygraphic":[97],"investigations":[98],"performed":[100],"between":[101,258,304],"22h30":[102],"06h00.":[104],"Subjects":[105],"received":[106],"orally":[109],"half":[110],"an":[111,224],"hour":[112],"before":[113],"bedtime.":[114],"A":[115],"self-rating":[116],"scale":[117],"for":[118],"awakening":[121,240,267],"quality":[122,228,241,268],"behavior":[126],"was":[127,175,229],"completed":[128],"toilet.":[133],"Thereafter,":[134],"noopsychic":[135],"thymopsychic":[137],"variables":[138,150],"utilizing":[141],"psychometric":[143,271],"test-battery.":[144],"Statistical":[145],"analyses":[146],"objective":[148,266],"demonstrated":[151],"that":[152],"modafinil":[153,219,233],"causes":[154],"no":[155,254],"significant":[156,251],"changes":[157],"as":[158,193,282],"placebo.":[162,286],"Sleep":[163],"initiation":[164],"remained":[165,295],"unchanged":[166],"after":[167,178,189,232,235,278],"all":[168],"drugs,":[171],"while":[172,218],"maintenance":[174],"impaired":[176],"dose-dependently":[177],"d-amphetamine.":[179],"Thus,":[180],"total":[181],"time":[183],"efficiency":[186],"decreased":[187],"significantly":[188,230,277],"d-amphetamine":[192,217,281],"placebo":[197,260],"modafinil.":[199,313],"regard":[201],"architecture":[204],"reduction":[206],"stage":[209],"2":[210],"rapid":[212],"eye":[213],"movement-sleep":[214],"occurred":[215],"under":[216],"did":[220,247],"not":[221,248],"exhibit":[222],"such":[223],"effect.":[225],"Subjective":[226,239],"better":[231],"than":[234],"reference":[237],"compound.":[238],"well-being":[243],"show":[249],"any":[250],"findings.":[252],"Furthermore,":[253],"differences":[255],"observed":[257],"other":[263],"concerning":[265],"(evaluated":[269],"by":[270],"tests).":[272],"Critical":[273],"flicker":[274],"frequency":[275],"increased":[276],"Pulse":[287],"rate":[288],"evening":[290],"blood":[293],"pressure":[294],"unchanged.":[296],"These":[297],"data":[298],"stress":[299],"necessity":[301],"differentiate":[303],"\"vigility-increasing\"":[305],"properties":[306,311],"amphetamine":[308],"\"vigilance-promoting\"":[310]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}