{"id":"https://openalex.org/W8051696","doi":null,"title":"AINEs y estatinas para el tratamiento de la Enfermedad de Alzheimer","display_name":"AINEs y estatinas para el tratamiento de la Enfermedad de Alzheimer","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W8051696","mag":"8051696"},"language":"es","primary_location":{"id":"pmh:oai:dialnet.unirioja.es:ART0000071645","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/oaiart?codigo=1988518","pdf_url":null,"source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archivos de medicina, ISSN 1698-9465, Vol. 2, N\u00ba. 2, 2006","raw_type":"text (article)"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102000639","display_name":"Manuel Men\u00e9ndez\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-5218-0774","observed_orcids":["https://orcid.org/0000-0002-5218-0774"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Men\u00e9ndez\u2010Gonz\u00e1lez","raw_affiliation_strings":["University of Oviedo*"],"raw_orcid":"https://orcid.org/0000-0002-5218-0774","affiliations":[{"raw_affiliation_string":"University of Oviedo*","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060544791","display_name":"Marta Mart\u00ednez Rivera","orcid":"https://orcid.org/0000-0001-7509-9357","observed_orcids":["https://orcid.org/0000-0001-7509-9357"]},"institutions":[{"id":"https://openalex.org/I4210163478","display_name":"Hospital Monte Naranco","ror":"https://ror.org/04c1s4764","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210163478","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Mart\u00ednez Rivera","raw_affiliation_strings":["Hospital Monte Naranco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Monte Naranco","institution_ids":["https://openalex.org/I4210163478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002394616","display_name":"Pablo P\u00e9rez\u2010Pi\u00f1era","orcid":"https://orcid.org/0000-0002-9167-0004","observed_orcids":["https://orcid.org/0000-0002-9167-0004"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo P\u00e9rez Pi\u00f1era","raw_affiliation_strings":["University of Oviedo*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oviedo*","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039809412","display_name":"Mar\u00eda Teresa Calatayud Noguera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Teresa Calatayud Noguera","raw_affiliation_strings":["University of Oviedo*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oviedo*","institution_ids":["https://openalex.org/I165339363"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00099751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"2","first_page":"1","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9739999771118164},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.871999979019165},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amyloid-pathology","display_name":"amyloid pathology","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/isoprenoid-pathway","display_name":"isoprenoid pathway","score":0.9020000100135803},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.8486924767494202},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.43443763256073}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dialnet.unirioja.es:ART0000071645","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/oaiart?codigo=1988518","pdf_url":null,"source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archivos de medicina, ISSN 1698-9465, Vol. 2, N\u00ba. 2, 2006","raw_type":"text (article)"},{"id":"mag:235340603","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/descarga/articulo/1988518.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401293","display_name":"Dialnet (Universidad de la Rioja)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168974976","host_organization_name":"Universidad de La Rioja","host_organization_lineage":["https://openalex.org/I168974976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:8051696","doi":null,"is_oa":false,"landing_page_url":"http://imed.pub/ojs2/index.php/archmed/article/download/7/7","pdf_url":null,"source":{"id":"https://openalex.org/S130261356","display_name":"Archivos de Medicina","issn_l":"1698-9465","issn":["1698-9465"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318851","host_organization_name":"Universidad de Manizales","host_organization_lineage":["https://openalex.org/P4310318851"],"host_organization_lineage_names":["Universidad de Manizales"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Archivos de Medicina","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W166560457","https://openalex.org/W1551964881","https://openalex.org/W1566291746","https://openalex.org/W1678111194","https://openalex.org/W1977451682","https://openalex.org/W1978841341","https://openalex.org/W1984964878","https://openalex.org/W1988892584","https://openalex.org/W1999607830","https://openalex.org/W2003188394","https://openalex.org/W2003898971","https://openalex.org/W2009145128","https://openalex.org/W2012983715","https://openalex.org/W2026453296","https://openalex.org/W2046454316","https://openalex.org/W2047613132","https://openalex.org/W2050881912","https://openalex.org/W2052644439","https://openalex.org/W2055092854","https://openalex.org/W2068477037","https://openalex.org/W2068932980","https://openalex.org/W2080550827","https://openalex.org/W2083556882","https://openalex.org/W2090811490","https://openalex.org/W2098878950","https://openalex.org/W2099556509","https://openalex.org/W2103071556","https://openalex.org/W2108326377","https://openalex.org/W2113690827","https://openalex.org/W2130823547","https://openalex.org/W2137497029","https://openalex.org/W2140954104","https://openalex.org/W2141362400","https://openalex.org/W2147486806","https://openalex.org/W2163110760","https://openalex.org/W2328351515"],"related_works":["https://openalex.org/W235340603","https://openalex.org/W2605074443","https://openalex.org/W2011359059","https://openalex.org/W7028720487","https://openalex.org/W3160646065","https://openalex.org/W2121147806","https://openalex.org/W1594133701","https://openalex.org/W3042562854","https://openalex.org/W1566291746","https://openalex.org/W2132041873"],"abstract_inverted_index":{"Los":[0,61],"estudios":[1,62,122,145],"observacionales":[2,123,146],"coinciden":[3],"en":[4,35,54,63,90,171,204],"se\u00f1alar":[5],"que":[6,75,100,108,125,127,132,149,196],"el":[7,13,83,202],"uso":[8],"prolongado":[9],"de":[10,15,18,25,30,32,42,48,57,70,107,110,116,140,147,155,163,167,177],"AINEs":[11,34],"reduce":[12],"riesgo":[14,139,154],"desarrollar":[16,141],"Enfermedad":[17],"Alzheimer":[19],"(EA)":[20],"y":[21,143,210],"retrasa":[22],"la":[23,26,36,43,71,105,117,174,181,190,208],"instauraci\u00f3n":[24],"enfermedad.":[27],"El":[28,165],"mecanismo":[29,166],"acci\u00f3n":[31,168],"los":[33,76,121,131,144],"EA":[37],"parece":[38],"ser":[39],"una":[40,67],"modulaci\u00f3n":[41],"gamma-secretasa,":[44],"bien":[45,51],"a":[46,130],"trav\u00e9s":[47],"las":[49,55,178,184],"ciclooxigenasas":[50],"por":[52,82,98,201],"inducci\u00f3n":[53],"mismas":[56],"un":[58,215],"cambio":[59],"alost\u00e9rico.":[60],"modelos":[64],"animales":[65],"demuestran":[66,126],"clara":[68],"disminuci\u00f3n":[69],"neuropatolog\u00eda":[72],"amiloidea":[73],"mientras":[74],"ensayos":[77,93],"cl\u00ednicos":[78,94],"no":[79,150],"han":[80],"conseguido":[81,200],"momento":[84,203],"demostrar":[85],"eficacia,":[86],"aunque":[87],"se":[88,133,212],"encuentran":[89],"curso":[91],"4":[92],"con":[95,173,180,183,189,218],"distintos":[96],"AINEs,":[97],"lo":[99],"a\u00fan":[101,211],"debemos":[102],"mantener":[103],"abierta":[104],"posibilidad":[106],"alguno":[109],"ellos":[111],"consiga":[112],"aprobaci\u00f3n":[113],"para":[114],"tratamiento":[115],"EA.\\nExiste":[118],"discrepancia":[119],"entre":[120],"caso-control,":[124],"aquellos":[128],"pacientes":[129],"les":[134],"prescrib\u00edan":[135],"estatinas":[136],"tienen":[137],"menor":[138],"demencia,":[142],"cohortes":[148],"hallaron":[151],"reducci\u00f3n":[152],"del":[153,192],"sufrir":[156],"ning\u00fan":[157],"tipo":[158],"demencia":[159],"tras":[160],"1-2":[161],"a\u00f1os":[162],"seguimiento.":[164],"puede":[169],"estar":[170],"relaci\u00f3n":[172],"capacidad":[175],"inmunomoduladora":[176],"estatinas,":[179],"interacci\u00f3n":[182,188],"secretasas":[185],"o":[186],"mediante":[187],"v\u00eda":[191],"isoprenoide.":[193],"La":[194],"estatina":[195],"m\u00e1s":[197],"\u00e9xito":[198],"ha":[199],"experimentaci\u00f3n":[205],"cl\u00ednica":[206],"es":[207],"atorvastatina":[209],"encuentra":[213],"activo":[214],"ensayo":[216],"cl\u00ednico":[217],"esta":[219],"mol\u00e9cula.":[220]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
