{"id":"https://openalex.org/W804877462","doi":null,"title":"Role of hypoxia-inducible factor-1 alpha in neural stem/progenitor cell function following hypoxia","display_name":"Role of hypoxia-inducible factor-1 alpha in neural stem/progenitor cell function following hypoxia","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W804877462","mag":"804877462"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/34","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1033&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1033&context=biom_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040047040","display_name":"Kate M. Candelario","orcid":"https://orcid.org/0000-0003-2290-2657","observed_orcids":["https://orcid.org/0000-0003-2290-2657"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kate M. Candelario","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2290-2657","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040047040"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02316922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.7490000128746033},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation","display_name":"oxygen-glucose deprivation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glycolytic-metabolism","display_name":"glycolytic metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/brain-repair","display_name":"brain repair","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7132555246353149},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6664921045303345},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.47669097781181335},{"id":"https://openalex.org/C31194975","wikidata":"https://www.wikidata.org/wiki/Q20970095","display_name":"HIF1A","level":3,"score":0.4705144464969635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43098607659339905},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.42649421095848083},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4171856939792633},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4115999937057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35846272110939026},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3543892502784729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32617777585983276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2789512276649475},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.255010187625885},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.13833710551261902},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.09716084599494934},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.09004145860671997},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/34","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1033&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},{"id":"mag:804877462","doi":null,"is_oa":false,"landing_page_url":"http://repository.unm.edu/handle/1928/12990","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/34","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1033&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W804877462.pdf","grobid_xml":"https://content.openalex.org/works/W804877462.grobid-xml"},"referenced_works_count":204,"referenced_works":["https://openalex.org/W86858381","https://openalex.org/W1514099358","https://openalex.org/W1514100422","https://openalex.org/W1533672300","https://openalex.org/W1550989298","https://openalex.org/W1589449569","https://openalex.org/W1643680178","https://openalex.org/W1768274470","https://openalex.org/W1849819493","https://openalex.org/W1859730138","https://openalex.org/W1906569886","https://openalex.org/W1924772544","https://openalex.org/W1964149603","https://openalex.org/W1965681567","https://openalex.org/W1965785177","https://openalex.org/W1969024031","https://openalex.org/W1969619562","https://openalex.org/W1972470996","https://openalex.org/W1974716477","https://openalex.org/W1976066269","https://openalex.org/W1976152949","https://openalex.org/W1978597908","https://openalex.org/W1981444928","https://openalex.org/W1981829804","https://openalex.org/W1982835579","https://openalex.org/W1983089266","https://openalex.org/W1983675756","https://openalex.org/W1984183927","https://openalex.org/W1985334727","https://openalex.org/W1986418714","https://openalex.org/W1987169758","https://openalex.org/W1987285745","https://openalex.org/W1987522740","https://openalex.org/W1990295156","https://openalex.org/W1990906839","https://openalex.org/W1990923337","https://openalex.org/W1991148019","https://openalex.org/W1991311502","https://openalex.org/W1992414855","https://openalex.org/W1992466747","https://openalex.org/W1994569384","https://openalex.org/W1995049749","https://openalex.org/W1997801266","https://openalex.org/W2000090066","https://openalex.org/W2000770398","https://openalex.org/W2001915682","https://openalex.org/W2002030791","https://openalex.org/W2002198698","https://openalex.org/W2002248781","https://openalex.org/W2002514998","https://openalex.org/W2002537553","https://openalex.org/W2004468189","https://openalex.org/W2004590336","https://openalex.org/W2006079390","https://openalex.org/W2010099473","https://openalex.org/W2011810742","https://openalex.org/W2012693239","https://openalex.org/W2014386715","https://openalex.org/W2015344488","https://openalex.org/W2016685143","https://openalex.org/W2017964197","https://openalex.org/W2018039414","https://openalex.org/W2020818011","https://openalex.org/W2021422667","https://openalex.org/W2024174118","https://openalex.org/W2024320298","https://openalex.org/W2024466310","https://openalex.org/W2025738240","https://openalex.org/W2026598324","https://openalex.org/W2026990513","https://openalex.org/W2027705428","https://openalex.org/W2030275112","https://openalex.org/W2031942587","https://openalex.org/W2032196626","https://openalex.org/W2033559853","https://openalex.org/W2033958147","https://openalex.org/W2035608099","https://openalex.org/W2035983112","https://openalex.org/W2036062846","https://openalex.org/W2036914347","https://openalex.org/W2039892303","https://openalex.org/W2042742511","https://openalex.org/W2043206878","https://openalex.org/W2043622238","https://openalex.org/W2043820074","https://openalex.org/W2044892825","https://openalex.org/W2047286267","https://openalex.org/W2047305865","https://openalex.org/W2048525391","https://openalex.org/W2049614454","https://openalex.org/W2050560941","https://openalex.org/W2050817965","https://openalex.org/W2051070943","https://openalex.org/W2052133467","https://openalex.org/W2052454749","https://openalex.org/W2056634709","https://openalex.org/W2057269156","https://openalex.org/W2057608998","https://openalex.org/W2058691572","https://openalex.org/W2058868183","https://openalex.org/W2061116292","https://openalex.org/W2061239191","https://openalex.org/W2062098209","https://openalex.org/W2062515127","https://openalex.org/W2063541896","https://openalex.org/W2063567991","https://openalex.org/W2064341136","https://openalex.org/W2064696266","https://openalex.org/W2065754676","https://openalex.org/W2066553255","https://openalex.org/W2067856703","https://openalex.org/W2068896673","https://openalex.org/W2068969996","https://openalex.org/W2069224399","https://openalex.org/W2069466069","https://openalex.org/W2070306500","https://openalex.org/W2070679665","https://openalex.org/W2070749449","https://openalex.org/W2073221687","https://openalex.org/W2073390876","https://openalex.org/W2073793186","https://openalex.org/W2074061707","https://openalex.org/W2074820129","https://openalex.org/W2075317738","https://openalex.org/W2076432328","https://openalex.org/W2076511723","https://openalex.org/W2077129920","https://openalex.org/W2077467483","https://openalex.org/W2077599130","https://openalex.org/W2079000034","https://openalex.org/W2079365338","https://openalex.org/W2082323684","https://openalex.org/W2083628520","https://openalex.org/W2084037323","https://openalex.org/W2084498863","https://openalex.org/W2084652820","https://openalex.org/W2085424855","https://openalex.org/W2089204174","https://openalex.org/W2090231093","https://openalex.org/W2091068407","https://openalex.org/W2092800106","https://openalex.org/W2095147658","https://openalex.org/W2095490681","https://openalex.org/W2095885953","https://openalex.org/W2096064481","https://openalex.org/W2096796354","https://openalex.org/W2097259163","https://openalex.org/W2098972920","https://openalex.org/W2099397203","https://openalex.org/W2099616702","https://openalex.org/W2101363175","https://openalex.org/W2103953491","https://openalex.org/W2104551938","https://openalex.org/W2104968232","https://openalex.org/W2105086774","https://openalex.org/W2107450931","https://openalex.org/W2108145145","https://openalex.org/W2108340830","https://openalex.org/W2109120242","https://openalex.org/W2109492293","https://openalex.org/W2109503237","https://openalex.org/W2115217673","https://openalex.org/W2116400580","https://openalex.org/W2117506912","https://openalex.org/W2118336842","https://openalex.org/W2118758371","https://openalex.org/W2119590183","https://openalex.org/W2119739306","https://openalex.org/W2120457826","https://openalex.org/W2121860798","https://openalex.org/W2122356899","https://openalex.org/W2122826701","https://openalex.org/W2123048941","https://openalex.org/W2124493352","https://openalex.org/W2125724189","https://openalex.org/W2126182481","https://openalex.org/W2127786249","https://openalex.org/W2129282529","https://openalex.org/W2129428247","https://openalex.org/W2129974396","https://openalex.org/W2133437679","https://openalex.org/W2133619319","https://openalex.org/W2134717451","https://openalex.org/W2135180965","https://openalex.org/W2135836641","https://openalex.org/W2136496098","https://openalex.org/W2141600996","https://openalex.org/W2143337494","https://openalex.org/W2145116035","https://openalex.org/W2148250994","https://openalex.org/W2148744621","https://openalex.org/W2150696636","https://openalex.org/W2151068043","https://openalex.org/W2151260260","https://openalex.org/W2153508530","https://openalex.org/W2164986141","https://openalex.org/W2165866239","https://openalex.org/W2166559804","https://openalex.org/W2167705610","https://openalex.org/W2168272960","https://openalex.org/W2169079203","https://openalex.org/W2172266256","https://openalex.org/W2414244206","https://openalex.org/W3188106608"],"related_works":["https://openalex.org/W2062235618","https://openalex.org/W2076511723","https://openalex.org/W2143309030","https://openalex.org/W4200109237","https://openalex.org/W1982002134","https://openalex.org/W2507862591","https://openalex.org/W2016862425","https://openalex.org/W2045128053","https://openalex.org/W2766321891","https://openalex.org/W3203986067"],"abstract_inverted_index":{"Stroke":[0],"can":[1,46],"be":[2,89,283],"caused":[3],"by":[4,13,36,161,285],"focal":[5],"ischemia":[6,15],"due":[7,98,106],"to":[8,22,88,91,99,107,151,191,224,227,250,262,282,343],"cerebral":[9],"artery":[10],"occlusion":[11],"or":[12],"global":[14,19],"that":[16,45,66,74,148,172,187,229,243,259,302,341],"occurs":[17,67],"when":[18],"blood":[20],"supply":[21],"the":[23,75,94,111,143,159,220,271,336],"brain":[24,32,350],"is":[25,34,78,139,246],"interrupted.":[26],"The":[27,319],"acute":[28],"phase":[29,56],"of":[30,41,53,102,110,118,123,129,135,146,195,222,235,265,274,321,327],"ischemic":[31,168],"injury":[33],"followed":[35],"a":[37,184,193,299],"more":[38,85],"prolonged":[39,156],"period":[40],"revascularization":[42],"and":[43,120,155,158,203,309,334],"repair":[44,55,121],"last":[47],"for":[48,80,113,248,338,348],"several":[49],"months.":[50],"One":[51],"hallmark":[52],"this":[54,207],"includes":[57],"an":[58,127],"endogenous":[59,328],"neural":[60],"stem/progenitor":[61],"cell":[62],"(NSPC)":[63],"regenerative":[64],"response":[65,77],"concomitant":[68],"with":[69],"angiogenesis.":[70],"Several":[71],"studies":[72,86,340],"suggest":[73],"cytogenic":[76],"beneficial":[79,95],"recovery":[81],"following":[82,316],"stroke,":[83],"however,":[84],"need":[87],"done":[90],"determine":[92,289],"whether":[93,290],"effects":[96],"are":[97],"functional":[100],"replacement":[101],"lost":[103],"neurons":[104,228],"and/or":[105],"nutritive":[108],"functions":[109],"NSPCs":[112,147,163,173,218,223,249,260,275,291,315],"penumbral":[114],"tissue.":[115],"Therapeutic":[116],"targeting":[117],"regeneration":[119],"phases":[122],"stroke":[124],"will":[125],"require":[126],"understanding":[128,326],"NSPC":[130,329,346],"function,":[131],"particularly":[132],"under":[133,181,276,331],"conditions":[134,278,333],"hypoxia/ischemia.":[136],"This":[137],"dissertation":[138],"focused":[140],"on":[141],"elucidating":[142],"metabolic":[144,272],"properties":[145,294,330],"allow":[149],"them":[150],"withstand":[152],"sudden":[153],"onset":[154],"hypoxia,":[157],"mechanisms":[160],"which":[162],"may":[164],"provide":[165,225],"neuroprotection":[166],"against":[167],"damage.":[169],"We":[170,240,257],"found":[171],"express":[174,305],"stabilized":[175],"hypoxia-inducible":[176],"factor-1":[177],"alpha":[178,215,245],"(HIF-1":[179],"alpha)":[180],"normoxic":[182,277],"conditions,":[183],"transcription":[185],"factor":[186],"has":[188],"been":[189],"shown":[190],"regulate":[192],"variety":[194],"genes":[196],"including":[197],"those":[198],"involved":[199],"in":[200,212,217,255,295,313],"angiogenesis,":[201],"neuroprotection,":[202],"glycolytic":[204],"metabolism.":[205],"In":[206],"dissertation,":[208],"we":[209,297],"show":[210,242],"that,":[211],"vitro,":[213],"HIF-1":[214,244,286],"expression":[216],"mediates":[219],"ability":[221],"protection":[226],"undergo":[230],"oxygen-glucose":[231],"deprivation":[232],"through":[233],"regulation":[234],"vascular":[236],"endothelial":[237],"growth":[238],"factor.":[239],"also":[241],"required":[247],"survive":[251],"24":[252],"h":[253],"anoxia":[254],"culture.":[256],"determined":[258],"appear":[261,281],"produce":[263],"most":[264],"their":[266],"ATP":[267],"via":[268],"glycolysis,":[269],"although":[270],"phenotype":[273],"does":[279],"not":[280],"regulated":[284],"alpha.":[287],"To":[288],"display":[292],"similar":[293],"vivo,":[296],"created":[298],"nestin-CreERT2/R26R-YFP/Hif1afl/fl":[300],"mouse":[301],"could":[303],"simultaneously":[304],"yellow":[306],"fluorescent":[307],"protein":[308],"delete":[310],"Hif1a":[311],"specifically":[312],"nestin-positive":[314],"tamoxifen":[317],"administration.":[318],"results":[320],"these":[322],"experiments":[323],"increase":[324],"our":[325],"hypoxic":[332],"form":[335],"basis":[337],"future":[339],"aim":[342],"therapeutically":[344],"manipulate":[345],"function":[347],"facilitating":[349],"repair.":[351]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}