{"id":"https://openalex.org/W80432145","doi":null,"title":"Long-term response to interferon plus ribavirin in patients with chronic hepatitis C refractory to interferon.","display_name":"Long-term response to interferon plus ribavirin in patients with chronic hepatitis C refractory to interferon.","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W80432145","mag":"80432145","pmid":"https://pubmed.ncbi.nlm.nih.gov/11482039"},"language":"en","primary_location":{"id":"pmid:11482039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11482039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de enfermedades digestivas","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061689613","display_name":"Mois\u00e9s Diago M","orcid":"https://orcid.org/0000-0002-8583-2433","observed_orcids":["https://orcid.org/0000-0002-8583-2433"]},"institutions":[{"id":"https://openalex.org/I4210127649","display_name":"Hospital General Universitario De Valencia","ror":"https://ror.org/03sz8rb35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127649"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Diago","raw_affiliation_strings":["Hepatology Section, Service of Digestive Diseases, Hospital General Universitario, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatology Section, Service of Digestive Diseases, Hospital General Universitario, Valencia, Spain","institution_ids":["https://openalex.org/I4210127649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026814211","display_name":"M. Luj\u00e0n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Luj\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005640639","display_name":"D Valeros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Valeros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026171906","display_name":"Concepci\u00f3n Tuset","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Tuset","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009040414","display_name":"Goizane Marcaida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Marcaida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021823105","display_name":"Vicente Carre\u00f1o Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081979817","display_name":"Rafael Cors","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Cors","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P Carbonell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Carbonell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4969,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70212766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"93","issue":"6","first_page":"353","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":1.0},{"id":"https://openalex.org/keywords/interferon-non-responders","display_name":"interferon non-responders","score":0.7110000252723694},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9589999914169312},{"id":"https://openalex.org/keywords/long-term-treatment-outcomes","display_name":"long-term treatment outcomes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.7429999709129333},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.6919999718666077},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/relapse-after-treatment-cessation","display_name":"relapse after treatment cessation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9362654685974121},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.8693879842758179},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8567222952842712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7305536866188049},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6980279684066772},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6420729160308838},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6316187381744385},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5379102826118469},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5015008449554443},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3796512484550476},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1645597219467163},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11482039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11482039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de enfermedades digestivas","raw_type":"Journal Article"},{"id":"mag:80432145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11482039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134603102","https://openalex.org/W2139315115","https://openalex.org/W2020669072","https://openalex.org/W2015496436","https://openalex.org/W3145708015","https://openalex.org/W2058660837","https://openalex.org/W2416887822","https://openalex.org/W1978739189","https://openalex.org/W1985882441","https://openalex.org/W2097221455"],"abstract_inverted_index":{"OBJECTIVE:":[0],"A":[1,52,67],"sustained":[2],"response":[3,109],"(SR)":[4],"to":[5,26,49,82,239,258,278,292],"interferon":[6],"(IFN)":[7],"is":[8],"only":[9],"observed":[10],"in":[11,44,111,245,261,273,290,297,301],"15-20%":[12],"of":[13,22,33,69,125,142,150,157,215,226,229,247,263,284],"patients":[14,46,72,161,175,264,275],"with":[15,36,87,146],"chronic":[16],"hepatitis":[17],"C":[18],"(CHC).":[19],"The":[20,181,197],"aim":[21],"this":[23,286],"study":[24,58],"was":[25,59,188,206],"determine":[27],"the":[28,34,140,143,155,158,223,250],"long-term":[29,282],"effectiveness":[30],"and":[31,54,78,96,107,122,128,136,168,172,193,203,209,236],"safety":[32],"treatment":[35,187],"IFN":[37,88,279,294],"plus":[38],"ribavirin":[39],"(RIB)":[40],"over":[41,61],"two":[42,184,204],"years":[43,185,205],"CHC":[45,71,274],"without":[47,276],"SR":[48,127,177,182,217,277,283],"IFN.":[50,83,240],"DESIGN:":[51],"prospective":[53],"open":[55],"longitudinal":[56],"follow-up":[57],"conducted":[60],"3":[62],"years.":[63],"PATIENTS":[64],"AND":[65],"METHODS:":[66],"total":[68],"77":[70],"were":[73,85,116,131,166,218,243],"included:":[74],"63":[75],"non-responders":[76,167],"(NR)":[77],"14":[79],"relapsers":[80,291],"(R)":[81],"Patients":[84],"treated":[86],"(3":[89],"MU":[90],"s.c.":[91],"three":[92],"times":[93],"a":[94,281],"week)":[95],"RIB":[97],"(1,000-1,200":[98],"mg":[99],"p.o.":[100],"daily)":[101],"for":[102,270],"12":[103,123,135,271],"months.":[104,180],"Treatment":[105,256],"tolerance":[106],"viral":[108],"(HCV-RNA":[110],"serum":[112],"<":[113],"1,000":[114],"copies/ml)":[115],"assessed":[117],"after":[118,139,178,186,200,233],"1,":[119],"3,":[120],"6":[121,179,201,234],"months":[124,138,202,272],"treatment.":[126],"relapsing":[129],"rates":[130],"subsequently":[132],"evaluated":[133],"6,":[134],"24":[137],"end":[141,156],"treatment,":[144,159,227],"together":[145],"those":[147],"variables":[148,213],"capable":[149,214],"predicting":[151,216],"SR.":[152],"RESULTS:":[153],"At":[154],"19/77":[160],"responded":[162],"(24.7%),":[163],"9/63":[164],"(14.3%)":[165],"10/14":[169],"(71.4%)":[170],"relapsers,":[171],"these":[173],"same":[174],"exhibited":[176],"rate":[183,199,287],"22.1%":[189],"[8/63":[190],"(12.7%)":[191],"NR":[192],"9/14":[194],"(64.3%)":[195],"R].":[196],"relapse":[198],"respectively":[207],"0":[208],"10.5%":[210],"(2/77).":[211],"Independent":[212],"negative":[219,231],"viremia":[220,232],"conversion":[221],"within":[222],"first":[224],"month":[225],"maintenance":[228],"such":[230],"months,":[235],"R":[237,298],"status":[238],"Side":[241],"effects":[242],"recorded":[244],"90.9%":[246],"cases":[248],"(70/77),":[249],"most":[251],"frequent":[252],"being":[253,288],"pseudoinfluenza":[254],"syndrome.":[255],"had":[257],"be":[259],"discontinued":[260],"33.8%":[262],"(26/77).":[265],"CONCLUSIONS:":[266],"Combined":[267],"IFN-RIB":[268],"therapy":[269,295],"obtains":[280],"22.1%,":[285],"higher":[289],"prior":[293],"(64.3%":[296],"versus":[299],"12.7%":[300],"NR).":[302]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
