{"id":"https://openalex.org/W8042307","doi":"https://doi.org/10.3748/wjg.v12.i16.2601","title":"Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity","display_name":"Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W8042307","doi":"https://doi.org/10.3748/wjg.v12.i16.2601","mag":"8042307","pmid":"https://pubmed.ncbi.nlm.nih.gov/16688809","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087996"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v12.i16.2601","doi":"https://doi.org/10.3748/wjg.v12.i16.2601","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i16.2601","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i16/2601.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W8042307"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v12/i16/2601.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036030883","display_name":"Zhuanzi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhuan-Zi Wang","raw_affiliation_strings":["Graduate School of Chinese Academy of Sciences, Beijing, China. yancz@lzb.ac.cn","Graduate School of Chinese Academy of Sciences Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Chinese Academy of Sciences, Beijing, China. yancz@lzb.ac.cn","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate School of Chinese Academy of Sciences Beijing, China","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161726223","display_name":"Wen-Jian Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Jian Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161681013","display_name":"Hong Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091488867","display_name":"Jianshe Yang","orcid":"https://orcid.org/0000-0001-7069-6072","observed_orcids":["https://orcid.org/0000-0001-7069-6072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-She Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161742748","display_name":"Rong Qiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161543235","display_name":"Xiao Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036030883"],"corresponding_institution_ids":["https://openalex.org/I19820366"],"apc_list":null,"apc_paid":null,"fwci":0.9129,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73205792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"16","first_page":"2601","last_page":"2601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.08160000294446945,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.7350000143051147},{"id":"https://openalex.org/keywords/premature-chromosome-condensation","display_name":"premature chromosome condensation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/radiation-induced-chromosome-damage","display_name":"radiation-induced chromosome damage","score":0.7319999933242798},{"id":"https://openalex.org/keywords/gamma-radiation","display_name":"gamma radiation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.503000020980835},{"id":"https://openalex.org/keywords/ovarian-cancer-cells","display_name":"ovarian cancer cells","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.9256078600883484},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.7596746683120728},{"id":"https://openalex.org/C73397532","wikidata":"https://www.wikidata.org/wiki/Q623749","display_name":"Chromatid","level":4,"score":0.6511492729187012},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6110764741897583},{"id":"https://openalex.org/C178108356","wikidata":"https://www.wikidata.org/wiki/Q7240230","display_name":"Premature chromosome condensation","level":4,"score":0.5913867950439453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5832557678222656},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.422946572303772},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37490400671958923},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.36330223083496094},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33031636476516724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29778891801834106},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2551862895488739},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.24735835194587708},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08447295427322388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3748/wjg.v12.i16.2601","doi":"https://doi.org/10.3748/wjg.v12.i16.2601","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i16.2601","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i16/2601.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3093376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087996","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:16688809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16688809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4087996","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4087996/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmh:oai:ir.impcas.ac.cn:113462/6153","doi":null,"is_oa":false,"landing_page_url":"http://ir.imp.cas.cn/handle/113462/6153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wang, ZZ (Zhuan-Zi Wang); Li, WJ (Wen-Jian Li); Zhang, H (Hong Zhang); Yang, JS (Jian-She Yang); Qiu, R (Rong Qiu); Wang, X (Xiao Wang).Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity ,WORLD JOURNAL OF GASTROENTEROLOGY,APR 28 2006,12(16):2601-2605","raw_type":"\u671f\u520a\u8bba\u6587"}],"best_oa_location":{"id":"doi:10.3748/wjg.v12.i16.2601","doi":"https://doi.org/10.3748/wjg.v12.i16.2601","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i16.2601","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i16/2601.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W8042307.pdf","grobid_xml":"https://content.openalex.org/works/W8042307.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W48814320","https://openalex.org/W1982003163","https://openalex.org/W1989340328","https://openalex.org/W1998803530","https://openalex.org/W2004224513","https://openalex.org/W2019424710","https://openalex.org/W2031878572","https://openalex.org/W2033793899","https://openalex.org/W2047242334","https://openalex.org/W2066821059","https://openalex.org/W2075597683","https://openalex.org/W2079344086","https://openalex.org/W2089025347","https://openalex.org/W2091904958","https://openalex.org/W2094543672","https://openalex.org/W2095327530","https://openalex.org/W2098581690","https://openalex.org/W2106076558","https://openalex.org/W2111511435","https://openalex.org/W2115157572","https://openalex.org/W2127507270","https://openalex.org/W2128692700","https://openalex.org/W2129742102","https://openalex.org/W2150807301","https://openalex.org/W2151565099","https://openalex.org/W2152626360","https://openalex.org/W2152685115","https://openalex.org/W2153059911","https://openalex.org/W2171245681","https://openalex.org/W2330023210","https://openalex.org/W2333440328"],"related_works":["https://openalex.org/W2035948700","https://openalex.org/W2387061680","https://openalex.org/W2015413791","https://openalex.org/W1974107872","https://openalex.org/W2347233639","https://openalex.org/W48814320","https://openalex.org/W2357906490","https://openalex.org/W1994992479","https://openalex.org/W2115781580","https://openalex.org/W2158875734"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"whether":[3],"the":[4,12,72,86,106,135,150,154,189],"number":[5,73,178],"of":[6,14,21,40,45,74,140,179,191],"non-rejoining":[7,49,75,119,141,156,180],"G2-chromatid":[8,50,66],"breaks":[9,51,67,78,121,158,183],"can":[10],"predict":[11],"radiosensitivity":[13,152,190],"human":[15,22,27],"cell":[16,46,101,130],"lines.":[17],"METHODS:":[18],"Cell":[19,57],"lines":[20],"ovary":[23],"carcinoma":[24],"cells":[25,29,33,195],"(HO8910),":[26],"hepatoma":[28],"(HepG2)":[30],"and":[31,42,48,103,132,153,193],"liver":[32],"(L02)":[34],"were":[35,68,173],"irradiated":[36],"with":[37],"a":[38,62],"range":[39],"doses":[41,171,202],"assessed":[43],"both":[44],"survival":[47,58,95],"at":[52,79,123],"24":[53,80,124],"h":[54,81,125],"after":[55,82,126],"irradiation.":[56],"was":[59,97,105,115,134,147],"documented":[60],"by":[61,70,85],"colony":[63],"assay.":[64],"Non-rejoining":[65],"measured":[69,122],"counting":[71],"G2":[76,181],"chromatid":[77],"irradiation,":[83],"detected":[84],"prematurely":[87],"chromosome":[88],"condensed":[89],"(PCC)":[90],"technique.":[91],"RESULTS:":[92],"A":[93,111,144],"linear-quadratic":[94],"curve":[96],"observed":[98,116],"in":[99,117,128],"three":[100],"lines,":[102,131],"HepG2":[104,133],"most":[107,136],"sensitive":[108],"to":[109,138],"gamma-radiation.":[110],"dose-dependent":[112],"linear":[113],"increase":[114],"radiation-induced":[118,155],"G2-PCC":[120,142,157],"irradiation":[127],"all":[129],"susceptible":[137],"induction":[139],"breaks.":[143],"close":[145],"correlation":[146],"found":[148],"between":[149],"clonogenic":[151],"(r":[159],"=":[160],"0.923).":[161],"Furthermore,":[162],"survival-aberration":[163],"correlations":[164],"for":[165,187],"two":[166,170,197,201],"or":[167,198],"more":[168,199],"than":[169,200],"lever":[172,203],"also":[174],"significant.":[175],"CONCLUSION:":[176],"The":[177],"PCC":[182],"holds":[184],"considerable":[185],"promise":[186],"predicting":[188],"normal":[192],"tumor":[194],"when":[196],"is":[204],"tested.":[205]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
