{"id":"https://openalex.org/W80295472","doi":"https://doi.org/10.1021/jf981340v","title":"Excretion of 14 C-Fumonisin B 1 , 14 C-Hydrolyzed Fumonisin B 1 , and 14 C-Fumonisin B 1 -Fructose in Rats","display_name":"Excretion of 14 C-Fumonisin B 1 , 14 C-Hydrolyzed Fumonisin B 1 , and 14 C-Fumonisin B 1 -Fructose in Rats","publication_year":1999,"publication_date":"1999-09-14","ids":{"openalex":"https://openalex.org/W80295472","doi":"https://doi.org/10.1021/jf981340v","mag":"80295472","pmid":"https://pubmed.ncbi.nlm.nih.gov/10552804"},"language":"en","primary_location":{"id":"doi:10.1021/jf981340v","doi":"https://doi.org/10.1021/jf981340v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf981340v","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083707862","display_name":"William R. Dantzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Dantzer","raw_affiliation_strings":["Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027787735","display_name":"J. G. Hopper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Hopper","raw_affiliation_strings":["Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065918290","display_name":"Kathy Mullin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy Mullin","raw_affiliation_strings":["Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023267063","display_name":"Suzanne Hendrich","orcid":"https://orcid.org/0000-0001-8700-4765","observed_orcids":["https://orcid.org/0000-0001-8700-4765"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Hendrich","raw_affiliation_strings":["Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111582133","display_name":"Patricia A. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia A. Murphy","raw_affiliation_strings":["Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science & Human Nutrition and Laboratory Animal Resources, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111582133"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8913,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.76866499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"10","first_page":"4291","last_page":"4296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fumonisin-b1","display_name":"fumonisin B1","score":0.996999979019165},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.746999979019165},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fusarium-proliferatum","display_name":"Fusarium proliferatum","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mycotoxin-metabolism","display_name":"mycotoxin metabolism","score":0.6869999766349792},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7110000252723694},{"id":"https://openalex.org/keywords/absorption","display_name":"absorption","score":0.35899999737739563},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2781429003","wikidata":"https://www.wikidata.org/wiki/Q420762","display_name":"Fumonisin B1","level":3,"score":0.829333484172821},{"id":"https://openalex.org/C2778431908","wikidata":"https://www.wikidata.org/wiki/Q3268331","display_name":"Fumonisin","level":3,"score":0.8228679299354553},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.7855308651924133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6177002191543579},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5792914032936096},{"id":"https://openalex.org/C2777341090","wikidata":"https://www.wikidata.org/wiki/Q5509912","display_name":"Fusarium proliferatum","level":3,"score":0.5351309180259705},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.5262340903282166},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4102093577384949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40087053179740906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2819640338420868},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.2463718056678772},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.22086665034294128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18482914566993713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11538788676261902}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005519","descriptor_name":"Food Preservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009183","descriptor_name":"Mycotoxins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009183","descriptor_name":"Mycotoxins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037341","descriptor_name":"Fumonisins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jf981340v","doi":"https://doi.org/10.1021/jf981340v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf981340v","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:10552804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10552804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:lib.dr.iastate.edu:fshn_ag_pubs-1095","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/fshn_ag_pubs/91","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Science and Human Nutrition Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W700660","https://openalex.org/W90184995","https://openalex.org/W642247737","https://openalex.org/W1499308810","https://openalex.org/W1514330796","https://openalex.org/W1564951305","https://openalex.org/W1808685515","https://openalex.org/W1831301545","https://openalex.org/W1915812970","https://openalex.org/W1971082817","https://openalex.org/W1972876206","https://openalex.org/W1984587800","https://openalex.org/W1989584164","https://openalex.org/W1992292988","https://openalex.org/W1998243002","https://openalex.org/W2001043662","https://openalex.org/W2008860913","https://openalex.org/W2017180361","https://openalex.org/W2020786596","https://openalex.org/W2034607407","https://openalex.org/W2035735208","https://openalex.org/W2050169105","https://openalex.org/W2051246432","https://openalex.org/W2052829770","https://openalex.org/W2072607078","https://openalex.org/W2077152741","https://openalex.org/W2093509534","https://openalex.org/W2117598555","https://openalex.org/W2167212778","https://openalex.org/W2400857118","https://openalex.org/W2443268396","https://openalex.org/W2490359817"],"related_works":["https://openalex.org/W642247737","https://openalex.org/W99606873","https://openalex.org/W2020786596","https://openalex.org/W1984587800","https://openalex.org/W2068713516","https://openalex.org/W1972990936","https://openalex.org/W2093509534","https://openalex.org/W2016199409","https://openalex.org/W2057400123","https://openalex.org/W2088604446"],"abstract_inverted_index":{"14C-Fumonisin":[0],"B(1)":[1],"(FB(1))":[2],"was":[3,55,65,77,152],"produced":[4],"by":[5,36],"Fusarium":[6],"proliferatum":[7],"M-5991":[8],"in":[9,83,107],"modified":[10],"Myro":[11],"liquid":[12],"medium":[13],"and":[14,28,53,57,64,69,150,165],"purified":[15],"to":[16,133,137,163],">95%":[17],"purity":[18],"with":[19,38,88,115],"a":[20,116,168],"specific":[21],"activity":[22],"of":[23,41,51,59,74,94,110,118,121,145,157,171],"1.7":[24],"mCi/mmol.":[25],"Nine":[26],"male":[27,68,89],"nine":[29],"female":[30,70,84],"F344/N":[31],"rats":[32,85,90],"were":[33,100],"each":[34],"dosed":[35],"gavage":[37],"0.69":[39],"micromol":[40],"(14)C-FB(1),":[42,147],"(14)C-hydrolyzed":[43,75,148,159],"FB(1),":[44,149],"or":[45],"(14)C-FB(1)-fructose/kg":[46],"body":[47],"weight.":[48],"Urinary":[49,72],"excretion":[50,73,109,144,156],"(14)C-FB(1)":[52,164],"(14)C-FB(1)-fructose":[54,151,166],"0.5%":[56],"4.4%":[58],"the":[60,95,111,122,146,158,172],"total":[61,96],"dose,":[62,97],"respectively,":[63],"similar":[66],"between":[67],"rats.":[71],"HFB(1)":[76],"significantly":[78],"greater":[79,169],"(P":[80,103],">":[81,104],"0.05)":[82,105],"as":[86,161],"compared":[87,162],"(17.3%":[91],"vs":[92],"12.8%":[93],"respectively).":[98],"There":[99],"no":[101],"significant":[102],"differences":[106],"biliary":[108,143],"three":[112],"fumonisin":[113],"compounds":[114],"mean":[117],"1.":[119],"4%":[120],"dose":[123],"excreted":[124,135],"at":[125],"4":[126],"h":[127,139],"after":[128,140],"dosing.":[129,141],"Lesser":[130],"amounts":[131],"continued":[132],"be":[134],"up":[136],"9.25":[138],"Although":[142],"similar,":[153],"increased":[154],"urinary":[155],"FB(1)":[160],"indicated":[167],"absorption":[170],"hydrolyzed":[173],"form.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}