{"id":"https://openalex.org/W80268276","doi":null,"title":"Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.","display_name":"Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.","publication_year":2005,"publication_date":"2005-09-02","ids":{"openalex":"https://openalex.org/W80268276","mag":"80268276"},"language":"en","primary_location":{"id":"pmh:oai:roderic.uv.es:10550/15125","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/15125","pdf_url":"http://hdl.handle.net/10550/15125","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10550/15125","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052252796","display_name":"Ana Villar\u2010Garea","orcid":"https://orcid.org/0000-0001-8960-1635","observed_orcids":["https://orcid.org/0000-0001-8960-1635"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Villar\u2010Garea","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8960-1635","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052252796"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.921999990940094},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.828000009059906},{"id":"https://openalex.org/keywords/procaine","display_name":"procaine","score":0.847000002861023},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.796999990940094},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.7250000238418579},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9279999732971191},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.6840000152587891},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8008353114128113},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7091548442840576},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.6759350895881653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5820655822753906},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5487251877784729},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5074076056480408},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.46619170904159546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4605516493320465},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.4108070731163025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36395877599716187},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.327404260635376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32357460260391235},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.29748666286468506},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28504884243011475},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.2823484539985657}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:roderic.uv.es:10550/15125","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/15125","pdf_url":"http://hdl.handle.net/10550/15125","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"pmh:oai:www.tdx.cat:10803/9526","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0628106-134822","pdf_url":"http://www.tdx.cat/TDX-0628106-134822","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/567009","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/567009","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/580852","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10550/15125","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:80268276","doi":null,"is_oa":false,"landing_page_url":"http://roderic.uv.es/handle/10550/15125","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:roderic.uv.es:10550/15125","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/15125","pdf_url":"http://hdl.handle.net/10550/15125","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W80268276.pdf","grobid_xml":"https://content.openalex.org/works/W80268276.grobid-xml"},"referenced_works_count":323,"referenced_works":["https://openalex.org/W45123465","https://openalex.org/W160911776","https://openalex.org/W264127248","https://openalex.org/W1484293540","https://openalex.org/W1516432813","https://openalex.org/W1517335907","https://openalex.org/W1522855936","https://openalex.org/W1530652941","https://openalex.org/W1546653512","https://openalex.org/W1556996865","https://openalex.org/W1576096421","https://openalex.org/W1585675256","https://openalex.org/W1605104953","https://openalex.org/W1607145333","https://openalex.org/W1608490912","https://openalex.org/W1659768997","https://openalex.org/W1673514954","https://openalex.org/W1677658690","https://openalex.org/W1807822788","https://openalex.org/W1812576394","https://openalex.org/W1817131636","https://openalex.org/W1897299284","https://openalex.org/W1917603270","https://openalex.org/W1920958927","https://openalex.org/W1934395836","https://openalex.org/W1935102817","https://openalex.org/W1945361080","https://openalex.org/W1949662878","https://openalex.org/W1963657604","https://openalex.org/W1964096828","https://openalex.org/W1964302569","https://openalex.org/W1964318436","https://openalex.org/W1964539968","https://openalex.org/W1965669510","https://openalex.org/W1966554737","https://openalex.org/W1966829835","https://openalex.org/W1967064280","https://openalex.org/W1968174732","https://openalex.org/W1969062733","https://openalex.org/W1969269167","https://openalex.org/W1969323007","https://openalex.org/W1969910220","https://openalex.org/W1972533251","https://openalex.org/W1973759523","https://openalex.org/W1974349078","https://openalex.org/W1974463288","https://openalex.org/W1975486218","https://openalex.org/W1976172452","https://openalex.org/W1977010911","https://openalex.org/W1977032812","https://openalex.org/W1977507636","https://openalex.org/W1977628064","https://openalex.org/W1977654605","https://openalex.org/W1977872548","https://openalex.org/W1978157954","https://openalex.org/W1979273476","https://openalex.org/W1981064450","https://openalex.org/W1981501904","https://openalex.org/W1981615091","https://openalex.org/W1982089215","https://openalex.org/W1982273994","https://openalex.org/W1982489603","https://openalex.org/W1982541898","https://openalex.org/W1982619775","https://openalex.org/W1987709906","https://openalex.org/W1987760376","https://openalex.org/W1988492454","https://openalex.org/W1988794054","https://openalex.org/W1989051882","https://openalex.org/W1990057158","https://openalex.org/W1991410988","https://openalex.org/W1991753493","https://openalex.org/W1993475919","https://openalex.org/W1994301929","https://openalex.org/W1994465394","https://openalex.org/W1995303686","https://openalex.org/W1996507777","https://openalex.org/W1997029250","https://openalex.org/W1997565776","https://openalex.org/W1998256752","https://openalex.org/W1998475911","https://openalex.org/W1998517881","https://openalex.org/W1998737325","https://openalex.org/W1999178101","https://openalex.org/W1999284470","https://openalex.org/W1999510229","https://openalex.org/W1999946050","https://openalex.org/W2000877431","https://openalex.org/W2001373252","https://openalex.org/W2004499293","https://openalex.org/W2005928381","https://openalex.org/W2008054969","https://openalex.org/W2008479450","https://openalex.org/W2008922065","https://openalex.org/W2011221870","https://openalex.org/W2011783533","https://openalex.org/W2012028536","https://openalex.org/W2012469190","https://openalex.org/W2012575565","https://openalex.org/W2012670964","https://openalex.org/W2014150894","https://openalex.org/W2015052870","https://openalex.org/W2016632389","https://openalex.org/W2018051857","https://openalex.org/W2018304597","https://openalex.org/W2019114478","https://openalex.org/W2019474060","https://openalex.org/W2020483638","https://openalex.org/W2020699105","https://openalex.org/W2021722016","https://openalex.org/W2021744310","https://openalex.org/W2023056476","https://openalex.org/W2023404623","https://openalex.org/W2024088186","https://openalex.org/W2024425375","https://openalex.org/W2024819383","https://openalex.org/W2025021474","https://openalex.org/W2025784041","https://openalex.org/W2027391379","https://openalex.org/W2028556682","https://openalex.org/W2029733458","https://openalex.org/W2029897520","https://openalex.org/W2030980795","https://openalex.org/W2031003536","https://openalex.org/W2031131841","https://openalex.org/W2032736838","https://openalex.org/W2033378658","https://openalex.org/W2033758245","https://openalex.org/W2034602099","https://openalex.org/W2035087809","https://openalex.org/W2035209422","https://openalex.org/W2036720950","https://openalex.org/W2037185271","https://openalex.org/W2039696546","https://openalex.org/W2040149948","https://openalex.org/W2040754208","https://openalex.org/W2040999102","https://openalex.org/W2043033879","https://openalex.org/W2044216740","https://openalex.org/W2044573387","https://openalex.org/W2045040554","https://openalex.org/W2046069528","https://openalex.org/W2047608167","https://openalex.org/W2049340909","https://openalex.org/W2049987819","https://openalex.org/W2050360708","https://openalex.org/W2050643804","https://openalex.org/W2050946836","https://openalex.org/W2052497922","https://openalex.org/W2053331671","https://openalex.org/W2053958797","https://openalex.org/W2054112754","https://openalex.org/W2054307692","https://openalex.org/W2055722183","https://openalex.org/W2056031143","https://openalex.org/W2056827933","https://openalex.org/W2057978402","https://openalex.org/W2058203909","https://openalex.org/W2058607217","https://openalex.org/W2059123635","https://openalex.org/W2060321052","https://openalex.org/W2060446375","https://openalex.org/W2061471485","https://openalex.org/W2061946349","https://openalex.org/W2064175713","https://openalex.org/W2065399757","https://openalex.org/W2066061693","https://openalex.org/W2066279187","https://openalex.org/W2066389184","https://openalex.org/W2067487392","https://openalex.org/W2069200751","https://openalex.org/W2069503557","https://openalex.org/W2069885647","https://openalex.org/W2070089404","https://openalex.org/W2070484728","https://openalex.org/W2070897057","https://openalex.org/W2073157961","https://openalex.org/W2075520328","https://openalex.org/W2076503198","https://openalex.org/W2076911571","https://openalex.org/W2077053535","https://openalex.org/W2077890483","https://openalex.org/W2078362264","https://openalex.org/W2078454854","https://openalex.org/W2079080667","https://openalex.org/W2079117752","https://openalex.org/W2081091627","https://openalex.org/W2082139701","https://openalex.org/W2082739830","https://openalex.org/W2083279359","https://openalex.org/W2083414728","https://openalex.org/W2083535257","https://openalex.org/W2084325219","https://openalex.org/W2084390009","https://openalex.org/W2084748297","https://openalex.org/W2085995080","https://openalex.org/W2086492419","https://openalex.org/W2089122195","https://openalex.org/W2090249473","https://openalex.org/W2091529776","https://openalex.org/W2093188241","https://openalex.org/W2093189184","https://openalex.org/W2093603211","https://openalex.org/W2095111919","https://openalex.org/W2097084183","https://openalex.org/W2097727084","https://openalex.org/W2097836350","https://openalex.org/W2097903491","https://openalex.org/W2098249941","https://openalex.org/W2099166288","https://openalex.org/W2099292393","https://openalex.org/W2102691929","https://openalex.org/W2103419911","https://openalex.org/W2104022826","https://openalex.org/W2104042521","https://openalex.org/W2104110616","https://openalex.org/W2104247152","https://openalex.org/W2104870341","https://openalex.org/W2106292925","https://openalex.org/W2106584820","https://openalex.org/W2106775330","https://openalex.org/W2106807780","https://openalex.org/W2107270084","https://openalex.org/W2107627035","https://openalex.org/W2107733280","https://openalex.org/W2108342665","https://openalex.org/W2109677420","https://openalex.org/W2109881276","https://openalex.org/W2109895173","https://openalex.org/W2111041465","https://openalex.org/W2113144329","https://openalex.org/W2113261653","https://openalex.org/W2113972309","https://openalex.org/W2114063466","https://openalex.org/W2114221123","https://openalex.org/W2114599216","https://openalex.org/W2115354390","https://openalex.org/W2116960636","https://openalex.org/W2118474157","https://openalex.org/W2118916005","https://openalex.org/W2118972462","https://openalex.org/W2120594989","https://openalex.org/W2120646148","https://openalex.org/W2121256763","https://openalex.org/W2121296685","https://openalex.org/W2121417064","https://openalex.org/W2122116522","https://openalex.org/W2123927456","https://openalex.org/W2126242600","https://openalex.org/W2126474190","https://openalex.org/W2126824096","https://openalex.org/W2127230663","https://openalex.org/W2128071342","https://openalex.org/W2128720603","https://openalex.org/W2128760892","https://openalex.org/W2130621926","https://openalex.org/W2131226513","https://openalex.org/W2131485957","https://openalex.org/W2131611809","https://openalex.org/W2132554729","https://openalex.org/W2134009718","https://openalex.org/W2135025419","https://openalex.org/W2135830745","https://openalex.org/W2136270288","https://openalex.org/W2136492640","https://openalex.org/W2136796186","https://openalex.org/W2136956385","https://openalex.org/W2137001129","https://openalex.org/W2137223619","https://openalex.org/W2139401049","https://openalex.org/W2139613313","https://openalex.org/W2140045506","https://openalex.org/W2140204965","https://openalex.org/W2140510283","https://openalex.org/W2141158999","https://openalex.org/W2141452262","https://openalex.org/W2142928043","https://openalex.org/W2144792857","https://openalex.org/W2144806790","https://openalex.org/W2145750252","https://openalex.org/W2147176162","https://openalex.org/W2147511945","https://openalex.org/W2148509326","https://openalex.org/W2148760132","https://openalex.org/W2149078121","https://openalex.org/W2149703257","https://openalex.org/W2149724080","https://openalex.org/W2149790281","https://openalex.org/W2151836161","https://openalex.org/W2152166370","https://openalex.org/W2153121423","https://openalex.org/W2153900602","https://openalex.org/W2155725346","https://openalex.org/W2155820845","https://openalex.org/W2158526038","https://openalex.org/W2159172903","https://openalex.org/W2159578337","https://openalex.org/W2161081212","https://openalex.org/W2161452781","https://openalex.org/W2161493114","https://openalex.org/W2162296692","https://openalex.org/W2162421580","https://openalex.org/W2163311832","https://openalex.org/W2163408209","https://openalex.org/W2164157942","https://openalex.org/W2166647372","https://openalex.org/W2168909179","https://openalex.org/W2171657985","https://openalex.org/W2172087672","https://openalex.org/W2182746672","https://openalex.org/W2312333799","https://openalex.org/W2313004864","https://openalex.org/W2316388803","https://openalex.org/W2401901272","https://openalex.org/W2407081633","https://openalex.org/W2408913229","https://openalex.org/W2409985478","https://openalex.org/W2415554219","https://openalex.org/W2421239614","https://openalex.org/W2511531422","https://openalex.org/W2952410637","https://openalex.org/W4299637024","https://openalex.org/W7097581514"],"related_works":["https://openalex.org/W2126242600","https://openalex.org/W1819264890","https://openalex.org/W2133738594","https://openalex.org/W7097611051","https://openalex.org/W2475155143","https://openalex.org/W2552981621","https://openalex.org/W2170918883","https://openalex.org/W7220502842","https://openalex.org/W2133856384","https://openalex.org/W2319765741"],"abstract_inverted_index":{"Genetic":[0],"alterations":[1,363,492],"and":[2,12,48,64,161,223,254,288,295,304,332,371,397,400,429,441,456,488,517,533,573],"deregulation":[3],"of":[4,14,44,60,66,83,91,104,109,128,140,146,158,167,189,202,206,211,277,308,322,329,338,353,392,406,454,466,470,474,486,508,536,548,571],"the":[5,10,19,22,32,41,45,81,92,102,110,144,147,165,174,181,187,209,320,326,347,362,365,390,404,407,410,420,430,436,451,472,475,482,491,495,506,558,569,575,582],"epigenetic":[6,23,42],"mechanisms":[7],"collaborate":[8],"in":[9,40,136,220,231,258,265,309,389,417,450,529,534,539,546,551,568],"initiation":[11],"progression":[13],"cancer.":[15],"In":[16,171],"contrast":[17],"to":[18,51,246,434],"genetic":[20],"defects,":[21],"abnormalities":[24],"are":[25,341,356,468],"potentially":[26],"reversible.":[27],"This":[28,235],"fact":[29,236],"has":[30],"driven":[31],"search":[33],"for":[34,281,343,358,382,395,403],"drugs":[35,366,496],"that":[36,132,364,481],"induce":[37,263,447],"selectively":[38],"changes":[39,449,501,564],"patterns":[43],"tumor":[46],"cells":[47,267],"thus":[49],"lead":[50],"differentiation,":[52],"cell":[53,56,177,252,256,369,372,383,414,424,498],"death":[54],"and/or":[55],"growth":[57,370,415],"arrest.":[58],"Inhibitors":[59],"DNA":[61,159,233,243],"(cytosine-5)-methyltransferases":[62],"(DNMTs)":[63],"inhibitors":[65,79,100,276,446],"Zn(II)-dependent":[67,278],"histone":[68,503,530],"deacetylases":[69],"(HDACs)":[70],"have":[71,120,130],"been":[72],"developed":[73],"with":[74,227,584],"this":[75],"purpose.":[76],"The":[77,98,274,306,380,500],"DNMTs":[78],"allow":[80,101],"reactivation":[82],"genes,":[84,87],"including":[85],"tumor-suppressor":[86],"silenced":[88,106],"through":[89],"hypermethylation":[90],"CpG":[93],"island":[94],"at":[95,113,214,427,438,460,505],"their":[96,114,134,333,461],"promoter.":[97],"HDACs":[99,169,279,524],"reexpression":[103],"genes":[105,510,576],"by":[107,494],"ypoacetylation":[108],"histones":[111],"associated":[112],"promoters.":[115],"Despite":[116,443],"all":[117,444,465],"these":[118,330,445],"chemicals":[119],"promising":[121],"effects":[122,166],"on":[123,315,368,376,497,502],"cultured":[124],"cancer":[125,176],"cells,":[126,222],"many":[127],"them":[129,467],"side-effects":[131],"limit":[133],"use":[135],"anticancer":[137],"chemotherapy.":[138],"Because":[139],"that,":[141],"we":[142,162],"analyzed":[143],"properties":[145],"anesthetic":[148],"procaine":[149,207,250],"(4-aminobenzoic":[150],"acid":[151],"2-diethylaminoethyl":[152],"ester)":[153],"as":[154,541,543],"a":[155,323,544],"new":[156],"inducer":[157],"demethylation":[160],"also":[163,567],"compared":[164],"seven":[168,275],"inhibitors.":[170],"both":[172,439],"cases,":[173],"breast":[175],"line":[178],"MCF7":[179,221,266,316],"was":[180],"model":[182],"system.":[183],"1.":[184],"Procaine":[185],"reduces":[186,251],"proportion":[188],"5-methylcytosine":[190],"into":[191],"global":[192,232,242,452],"genomic":[193],"DNA,":[194],"achieving":[195],"its":[196,225,377],"maximum":[197],"effect":[198],"within":[199],"24-48":[200],"h":[201,386],"treatment.":[203,562],"Low":[204],"concentrations":[205,337,352,394],"decrease":[208,230,545],"amount":[210],"5-":[212],"methylcytosine":[213],"RAR\u00a6\u00c22":[215],"promoter,":[216],"which":[217],"is":[218,388,555],"hypermethylated":[219],"reactivate":[224,471],"expression":[226,473,484,578],"only":[228],"small":[229],"methylation.":[234],"could":[237],"be":[238],"an":[239,527],"advantage,":[240],"since":[241],"hypomethylation":[244],"leads":[245],"chromosomal":[247],"instability.":[248],"Finally,":[249],"proliferation":[253],"arrests":[255],"cycle":[257,373,425,437],"mitosis,":[259],"but":[260],"does":[261],"not":[262,464],"apoptosis":[264],"after":[268,581],"treatments":[269,384],"3":[270],"days":[271],"long.":[272],"2.":[273],"chosen":[280],"comparison":[282],"were:":[283],"two":[284],"carboxylic":[285,354,431],"acids":[286,340,355,399,422,432],"(butanoic":[287],"valproic":[289,398],"acid);":[290],"one":[291],"N-(2\u00a1\u00af-aminophenyl)":[292],"benzamide":[293],"(MS-275);":[294],"four":[296],"hydroxamic":[297,301,339,421],"acids(trichostatin":[298],"A,":[299],"suberoylanilide":[300],"acid,":[302],"CX":[303],"CY).":[305],"results":[307],"vitro":[310],"HDAC":[311],"activity":[312],"assays":[313],"performed":[314],"nuclear":[317],"extracts":[318],"show":[319],"existence":[321],"relationship":[324],"between":[325],"chemical":[327,378],"structure":[328],"compounds":[331],"activity:":[334],"low":[335,401],"micromolar":[336,402],"sufficient":[342],"inhibiting":[344],"almost":[345],"completely":[346],"deacetylase":[348],"activity,":[349],"whereas":[350,419],"millimolar":[351,393],"required":[357],"similar":[359,448],"effects.":[360],"Also":[361],"cause":[367],"arrest":[374,416,435],"depend":[375],"structure.":[379],"IC50":[381],"24":[385],"long":[387],"range":[391],"butanoic":[396],"rest":[405],"chemicals.":[408],"At":[409],"IC50,":[411,463],"MS-275":[412],"induces":[413,526],"G1/G0,":[418],"stop":[423],"mostly":[426],"G2/M":[428],"seems":[433,480],"G1/G0":[440],"G2/M.":[442],"acetylation":[453],"H4":[455,531],"H3":[457],"when":[458],"employed":[459],"respective":[462],"able":[469],"same":[476],"genes.":[477],"Moreover,":[478],"it":[479],"induced":[483,493],"levels":[485],"CDKN1A":[487],"GADD45\u00a6\u00c2":[489],"determine":[490],"cycle.":[499],"modifications":[504],"promoters":[507,559,570],"six":[509],"(":[511],"CDKN1A,":[512],"GADD45\u00a6\u00c2,":[513],"JunD,":[514],"IGFBP3,":[515],"MT1X":[516,572],"MT2A)":[518],"upon":[519,560],"CY":[520,561],"treatment":[521,583],"were":[522],"studied.":[523],"inhibition":[525],"increase":[528],"tetraacetylation":[532],"dimethylation":[535,547],"lysine":[537,549],"4":[538],"H3,":[540],"well":[542],"9":[550],"H3.":[552],"Additionally,":[553],"HDAC2":[554],"released":[556],"from":[557],"These":[563],"take":[565],"place":[566],"MT2A,":[574],"whose":[577],"remains":[579],"unaltered":[580],"CY.":[585]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
