{"id":"https://openalex.org/W8017007","doi":null,"title":"THE ROLE OF THE SEPTOHIPPOCAMPAL CHOLINERGIC SYSTEM IN COGNITIVE FUNCTIONS","display_name":"THE ROLE OF THE SEPTOHIPPOCAMPAL CHOLINERGIC SYSTEM IN COGNITIVE FUNCTIONS","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W8017007","mag":"8017007"},"language":"en","primary_location":{"id":"mag:8017007","doi":null,"is_oa":false,"landing_page_url":"https://www.uef.fi/documents/1085457/1371730/54the.pdf/32aaf91c-b8b2-4bf7-8b14-68e1c3da9e9c","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078731023","display_name":"Kuopion Yliopisto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuopion Yliopisto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037764939","display_name":"Sami Ikonen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sami Ikonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4676,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.5810993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septohippocampal-cholinergic-system","display_name":"septohippocampal cholinergic system","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cholinergic-dysfunction","display_name":"cholinergic dysfunction","score":0.8920000195503235},{"id":"https://openalex.org/keywords/apamin","display_name":"apamin","score":0.6899999976158142},{"id":"https://openalex.org/keywords/trichlorfon","display_name":"trichlorfon","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hippocampal-lesions","display_name":"hippocampal lesions","score":0.9869999885559082},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hippocampal-theta-rhythm","display_name":"hippocampal theta rhythm","score":0.7730000019073486},{"id":"https://openalex.org/keywords/place-cells","display_name":"place cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pattern-separation","display_name":"pattern separation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pattern-completion","display_name":"pattern completion","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C2776919887","wikidata":"https://www.wikidata.org/wiki/Q417260","display_name":"Apamin","level":3,"score":0.8559716939926147},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6736757159233093},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6705595850944519},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6637091636657715},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6461597681045532},{"id":"https://openalex.org/C12515866","wikidata":"https://www.wikidata.org/wiki/Q50628021","display_name":"Water maze","level":3,"score":0.5187785625457764},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4700530767440796},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4449107348918915},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4174976050853729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.333837628364563},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.296492338180542},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.24817156791687012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2010928988456726}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:8017007","doi":null,"is_oa":false,"landing_page_url":"https://www.uef.fi/documents/1085457/1371730/54the.pdf/32aaf91c-b8b2-4bf7-8b14-68e1c3da9e9c","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":151,"referenced_works":["https://openalex.org/W12986470","https://openalex.org/W22185870","https://openalex.org/W181238556","https://openalex.org/W589850836","https://openalex.org/W608067738","https://openalex.org/W658467397","https://openalex.org/W1506209295","https://openalex.org/W1508825618","https://openalex.org/W1519616018","https://openalex.org/W1537685381","https://openalex.org/W1540330207","https://openalex.org/W1563845916","https://openalex.org/W1568121073","https://openalex.org/W1587160774","https://openalex.org/W1597264233","https://openalex.org/W1603106091","https://openalex.org/W1605797652","https://openalex.org/W1607428171","https://openalex.org/W1966103661","https://openalex.org/W1969769253","https://openalex.org/W1970616082","https://openalex.org/W1971653931","https://openalex.org/W1971744915","https://openalex.org/W1972197544","https://openalex.org/W1972718612","https://openalex.org/W1972859266","https://openalex.org/W1973085548","https://openalex.org/W1974018894","https://openalex.org/W1974113935","https://openalex.org/W1975862204","https://openalex.org/W1979476827","https://openalex.org/W1979486221","https://openalex.org/W1979530856","https://openalex.org/W1979686107","https://openalex.org/W1981695661","https://openalex.org/W1982064952","https://openalex.org/W1985232500","https://openalex.org/W1987369275","https://openalex.org/W1987526918","https://openalex.org/W1988485844","https://openalex.org/W1989619711","https://openalex.org/W1990441521","https://openalex.org/W1990542201","https://openalex.org/W1990640328","https://openalex.org/W1990753810","https://openalex.org/W1991695937","https://openalex.org/W1992223942","https://openalex.org/W1992388076","https://openalex.org/W1994067502","https://openalex.org/W1995188023","https://openalex.org/W1995403150","https://openalex.org/W1995581633","https://openalex.org/W2000292298","https://openalex.org/W2002085774","https://openalex.org/W2004073629","https://openalex.org/W2008772754","https://openalex.org/W2008798843","https://openalex.org/W2009928698","https://openalex.org/W2010551875","https://openalex.org/W2010875080","https://openalex.org/W2012551683","https://openalex.org/W2013027575","https://openalex.org/W2014127226","https://openalex.org/W2015692984","https://openalex.org/W2015756255","https://openalex.org/W2016659621","https://openalex.org/W2016943722","https://openalex.org/W2017169966","https://openalex.org/W2018041359","https://openalex.org/W2018434736","https://openalex.org/W2018503518","https://openalex.org/W2018964056","https://openalex.org/W2020272049","https://openalex.org/W2021346798","https://openalex.org/W2022864922","https://openalex.org/W2026183536","https://openalex.org/W2028934645","https://openalex.org/W2029501430","https://openalex.org/W2032118090","https://openalex.org/W2033121351","https://openalex.org/W2037767516","https://openalex.org/W2039802534","https://openalex.org/W2041800086","https://openalex.org/W2042916788","https://openalex.org/W2043392919","https://openalex.org/W2045683730","https://openalex.org/W2045946963","https://openalex.org/W2046769649","https://openalex.org/W2046960293","https://openalex.org/W2047399799","https://openalex.org/W2047750300","https://openalex.org/W2048528277","https://openalex.org/W2049289902","https://openalex.org/W2049948139","https://openalex.org/W2050046507","https://openalex.org/W2050557318","https://openalex.org/W2052515926","https://openalex.org/W2052602887","https://openalex.org/W2052898293","https://openalex.org/W2056615752","https://openalex.org/W2056838173","https://openalex.org/W2057182436","https://openalex.org/W2057793088","https://openalex.org/W2058113871","https://openalex.org/W2058996065","https://openalex.org/W2059680732","https://openalex.org/W2061664301","https://openalex.org/W2061883053","https://openalex.org/W2062060507","https://openalex.org/W2064243563","https://openalex.org/W2064618087","https://openalex.org/W2066800543","https://openalex.org/W2069435892","https://openalex.org/W2071593047","https://openalex.org/W2071637530","https://openalex.org/W2071763142","https://openalex.org/W2072926455","https://openalex.org/W2076425653","https://openalex.org/W2077785499","https://openalex.org/W2080061206","https://openalex.org/W2080071110","https://openalex.org/W2083530736","https://openalex.org/W2084199611","https://openalex.org/W2089413581","https://openalex.org/W2089662788","https://openalex.org/W2090676343","https://openalex.org/W2093374391","https://openalex.org/W2098951907","https://openalex.org/W2103692957","https://openalex.org/W2104227586","https://openalex.org/W2110765139","https://openalex.org/W2118112683","https://openalex.org/W2120250915","https://openalex.org/W2126561217","https://openalex.org/W2128042752","https://openalex.org/W2133052659","https://openalex.org/W2142276934","https://openalex.org/W2142925815","https://openalex.org/W2149514592","https://openalex.org/W2152185487","https://openalex.org/W2154548294","https://openalex.org/W2163815564","https://openalex.org/W2165129700","https://openalex.org/W2167403166","https://openalex.org/W2168849139","https://openalex.org/W2280108666","https://openalex.org/W2410446460","https://openalex.org/W3148499377","https://openalex.org/W4238666786","https://openalex.org/W4406056526","https://openalex.org/W7098038332"],"related_works":["https://openalex.org/W1983793840","https://openalex.org/W21528754","https://openalex.org/W2411473729","https://openalex.org/W2077912875","https://openalex.org/W1751585141","https://openalex.org/W2754644051","https://openalex.org/W1519616018","https://openalex.org/W7163364453","https://openalex.org/W4312077009","https://openalex.org/W2082284920"],"abstract_inverted_index":{"Cholinergic":[0],"dysfunction":[1,10],"is":[2,11,34,99,396],"a":[3,77,157,171,257,278,283,334,353,426,446],"hallmark":[4],"of":[5,45,89,118,123,128,144,167,181,191,207,212,224,261,270,289,316,330,339,401,408,415,419,436,441,453,459,475],"Alzheimer\u2019s":[6],"disease":[7],"(AD).":[8],"This":[9,36],"assumed":[12],"to":[13,40,83,138,176,196,219,248,266,273,277,302,398],"be":[14,220,249],"mainly":[15],"responsible":[16],"for":[17],"the":[18,24,28,43,46,115,141,154,164,178,189,202,225,240,262,268,271,286,303,306,314,321,324,328,336,340,345,349,359,363,374,380,384,406,409,413,416,420,429,437,442,451],"cognitive":[19,32,51,116,381,394],"defects":[20],"in":[21,50,101,149,229,233,239,275,310,313,320,327,348,358,412],"AD.":[22],"However,":[23,232,298],"mechanism":[25],"by":[26,108,222,251,449],"which":[27],"cholinergic":[29,48,259,365,410,422,443,479],"system":[30,49,366,411,444],"regulates":[31,379,388],"functions":[33,395],"elusive.":[35],"study":[37],"was":[38,81,104,131,135,160,174,264],"designed":[39],"find":[41],"out":[42],"role":[44,407],"septohippocampal":[47,364],"functions.":[52],"The":[53,95,126,210,391],"methods":[54],"used":[55],"were":[56,216,246],"behavioural":[57],"testing":[58],"(water":[59],"maze,":[60,63,156],"radial":[61,150],"arm":[62,151],"passive":[64,121],"avoidance":[65,122],"and":[66,68,72,120,214,243,291,383,432],"Y-maze)":[67],"electrophysiology":[69],"(hippocampal":[70],"EEG-recording":[71],"place":[73,287,307],"cell":[74,308],"recording).":[75],"Apamin,":[76],"potassium":[78],"channel":[79],"blocker,":[80],"found":[82,137,175,265],"improve":[84,201],"water":[85,155,203],"maze":[86,204,485],"spatial":[87,165,205,483],"navigation":[88,166,206],"medial":[90],"septal":[91],"(MS)":[92],"lesioned":[93,147,290,322,350],"mice.":[94,125,169,183,193,209,231],"memory":[96,142,179,447],"defect":[97,143,180,448],"that":[98],"present":[100],"MS-lesioned":[102,124,182,230],"mice":[103,130,148],"almost":[105],"completely":[106],"reversed":[107],"apamin.":[109],"Apamin":[110,134],"had":[111,185,295],"no":[112,186],"effect":[113,187,392],"on":[114,188,373,393],"parameters":[117],"Y-maze":[119],"performance":[127,190],"intact":[129,192,234],"not":[132,200,218],"affected.":[133],"also":[136],"dose-dependently":[139],"reverse":[140],"hippocampal":[145,226,241,389],"(HC)":[146],"maze.":[152],"In":[153,194,255,282],"similar":[158,296],"observation":[159],"made:":[161],"apamin":[162,215],"improved":[163],"HC-lesioned":[168],"Metrifonate,":[170],"cholinesterase":[172],"inhibitor,":[173],"alleviate":[177],"Metrifonate":[184],"contrast":[195],"apamin,":[197],"metrifonate":[198,213,236],"did":[199],"hippocampal-lesioned":[208],"effects":[211,372],"observed":[217],"mediated":[221,250],"modulation":[223],"theta":[227,490],"rhythm":[228],"mice,":[235],"induced":[237],"changes":[238,245],"theta,":[242],"these":[244],"shown":[247],"non-M1M2":[252],"muscarinic":[253],"receptors.":[254],"addition,":[256],"selective":[258],"lesion":[260],"septum":[263,474],"impair":[267],"ability":[269],"hippocampus":[272],"remap":[274],"response":[276,309],"new":[279,304,341,355],"visual":[280],"environment.":[281],"familiar":[284,346],"environment,":[285,305],"fields":[288],"sham":[292],"operated":[293],"animals":[294,323],"characteristics.":[297],"upon":[299],"subsequent":[300],"exposures":[301],"controls":[311],"evolved":[312,326],"direction":[315,329],"pattern":[317,325,331],"separation,":[318],"whereas":[319,352],"completion.":[332],"As":[333],"result,":[335],"final":[337],"representation":[338,356],"environment":[342,347],"still":[343],"resembled":[344],"rats":[351,495],"totally":[354],"developed":[357],"controls.":[360],"Taken":[361],"together,":[362],"has":[367],"at":[368],"least":[369],"two":[370],"differential":[371],"hippocampus:":[375,421],"one,":[376],"M1-mediated":[377],"effect,":[378,387],"functions,":[382],"other,":[385],"M3/M5-mediated":[386],"EEG.":[390],"likely":[397],"involve":[399],"inhibition":[400],"afterhyperpolarisation.":[402],"These":[403],"findings":[404],"support":[405],"regulation":[414],"predominant":[417],"mode":[418],"innervation":[423],"acts":[424],"as":[425],"switch":[427],"between":[428],"information":[430,433,454],"gathering":[431,455],"processing":[434],"modes":[435],"hippocampus.":[438],"Thus,":[439],"degeneration":[440],"induces":[445],"reducing":[450],"occurrence":[452],"mode.":[456],"National":[457],"Library":[458],"Medicine":[460],"Classification:":[461],"WL":[462,464],"314,":[463],"102,":[465],"WT":[466],"155":[467],"Medical":[468],"Subject":[469],"Headings:":[470],"Alzheimer":[471],"disease;":[472],"hippocampus;":[473],"brain;":[476],"apamin;":[477],"trichlorfon;":[478],"agents;":[480],"receptors,":[481],"muscarinic;":[482],"behavior;":[484],"learning;":[486],"memory;":[487],"cognition;":[488],"electroencephalography;":[489],"rhythm;":[491],"models,":[492],"animal;":[493],"mice;":[494]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}