{"id":"https://openalex.org/W80061229","doi":"https://doi.org/10.1096/fasebj.21.6.a1264-c","title":"6\u2010Hydroxydopamine treatment depletes norepinephrine but does not reduce other markers of sympathetic neurons in the heart.","display_name":"6\u2010Hydroxydopamine treatment depletes norepinephrine but does not reduce other markers of sympathetic neurons in the heart.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W80061229","doi":"https://doi.org/10.1096/fasebj.21.6.a1264-c","mag":"80061229"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1264-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1264-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1264-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009764860","display_name":"Mohammad Esfahanian","orcid":"https://orcid.org/0000-0002-3926-3575","observed_orcids":["https://orcid.org/0000-0002-3926-3575"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Esfahanian","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022732945","display_name":"Erica A. Wehrwein","orcid":"https://orcid.org/0000-0002-5197-2147","observed_orcids":["https://orcid.org/0000-0002-5197-2147"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica A Wehrwein","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010886126","display_name":"Lindsay Marie Parker","orcid":"https://orcid.org/0000-0002-4545-8811","observed_orcids":["https://orcid.org/0000-0002-4545-8811"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay M Parker","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019274579","display_name":"Anna Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna A Wright","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006582557","display_name":"Joshua D. Mastenbrook","orcid":"https://orcid.org/0000-0002-9928-3674","observed_orcids":["https://orcid.org/0000-0002-9928-3674"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Mastenbrook","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002671896","display_name":"Martin Novotn\u00fd","orcid":"https://orcid.org/0000-0001-6446-7257","observed_orcids":["https://orcid.org/0000-0001-6446-7257"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Novotny","raw_affiliation_strings":["Chemistry Michigan State University 306 Chemistry East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Michigan State University 306 Chemistry East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057672278","display_name":"Veronika Mocko","orcid":"https://orcid.org/0000-0001-6041-6778","observed_orcids":["https://orcid.org/0000-0001-6041-6778"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronika Mocko","raw_affiliation_strings":["Chemistry Michigan State University 306 Chemistry East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Michigan State University 306 Chemistry East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073641507","display_name":"Greg M. Swain","orcid":"https://orcid.org/0000-0001-6498-8351","observed_orcids":["https://orcid.org/0000-0001-6498-8351"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M Swain","raw_affiliation_strings":["Chemistry Michigan State University 306 Chemistry East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Michigan State University 306 Chemistry East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020174556","display_name":"David L. Kreulen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L Kreulen","raw_affiliation_strings":["Physiology Michigan State University 2105 BPS East Lansing MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Michigan State University 2105 BPS East Lansing MI 48824","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01399209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.18770000338554382,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.1704999953508377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":1.0},{"id":"https://openalex.org/keywords/chemical-sympathectomy","display_name":"chemical sympathectomy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/norepinephrine-depletion","display_name":"norepinephrine depletion","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiac-sympathetic-nerves","display_name":"cardiac sympathetic nerves","score":0.7870000004768372},{"id":"https://openalex.org/keywords/right-atrium","display_name":"right atrium","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-gene-product-9-5","display_name":"protein gene product 9.5","score":0.8799999952316284},{"id":"https://openalex.org/keywords/catecholamine-transporters","display_name":"catecholamine transporters","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cardiac-innervation","display_name":"cardiac innervation","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2911016594","wikidata":"https://www.wikidata.org/wiki/Q15946111","display_name":"Hydroxydopamine","level":4,"score":0.8851220607757568},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.8651589155197144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7070263624191284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7033138871192932},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6884859800338745},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.6775121688842773},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.6692981123924255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5371751189231873},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.49313753843307495},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.492123544216156},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.46543872356414795},{"id":"https://openalex.org/C2777288102","wikidata":"https://www.wikidata.org/wiki/Q780181","display_name":"Oxidopamine","level":5,"score":0.4116849899291992},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.33569955825805664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30664220452308655},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3012835383415222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13484397530555725},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.1330767571926117},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1174432635307312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1143198311328888},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.08087590336799622}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1264-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1264-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1264-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992817289","https://openalex.org/W2047054609","https://openalex.org/W2222007911","https://openalex.org/W1984889164","https://openalex.org/W7100643643","https://openalex.org/W2167583907","https://openalex.org/W2112426670","https://openalex.org/W2210680819","https://openalex.org/W2295059694","https://openalex.org/W2058977564"],"abstract_inverted_index":{"6\u2010hydroxydopamine":[0],"(6\u2010OHDA)":[1],"is":[2,25],"used":[3],"to":[4,39,64,165,192],"\u201cchemically":[5],"denervate\u201d":[6],"tissues":[7],"innervated":[8],"by":[9,83],"nerves":[10],"containing":[11],"catecholamine":[12],"transporters.":[13],"Treatment":[14],"reduces":[15],"the":[16,21,41,50,93,121,146,158,193],"norepinephrine":[17],"(NE)":[18],"content":[19],"of":[20,30,35,43,136,160,195],"heart":[22,177],"but":[23],"little":[24],"known":[26],"about":[27],"other":[28,176],"markers":[29],"sympathetic":[31,47,185],"nerves.":[32],"The":[33],"purpose":[34],"this":[36],"study":[37],"was":[38,62,75,95,103],"examine":[40],"effects":[42],"6\u2010OHDA":[44,53,180],"on":[45,68],"cardiac":[46,184],"neurons":[48,107],"innervating":[49],"right":[51,147],"atrium.":[52],"(250":[54],"mg/kg,":[55],"sub.q,":[56],"3":[57],"doses":[58],"over":[59],"7":[60,70],"days)":[61],"administered":[63],"adult":[65],"rats":[66],"and":[67,142],"day":[69],"hearts":[71],"were":[72,172],"removed.":[73],"There":[74],"a":[76],"significant":[77],"decrease":[78],"in":[79,106,116,145,157,174],"NE":[80,137],"levels":[81,159],"determined":[82],"capillary":[84],"electrophoresis":[85],"with":[86],"electrochemical":[87],"detection":[88],"(p<0.001,":[89],"n=3)":[90],"confirming":[91],"that":[92],"treatment":[94],"effective.":[96],"However,":[97],"immunocytochemical":[98],"staining":[99],"showed":[100,154],"tyrosine":[101],"hydroxylase":[102],"still":[104],"visible":[105],"after":[108],"denervation":[109],"(n=3).":[110],"Western":[111],"blotting":[112],"revealed":[113],"no":[114,155],"differences":[115],"protein":[117],"expression":[118],"for":[119,131,162],"either":[120],"neuronal":[122],"marker":[123],"Protein":[124],"Gene":[125],"Product":[126],"9.5":[127],"(p>0.05,":[128,168],"n=4)":[129],"or":[130],"three":[132],"molecular":[133],"weight":[134],"variants":[135],"transporter":[138],"(NET)":[139],"(80,":[140],"54,":[141],"46":[143],"kD)":[144],"atria":[148],"(p>0.05.":[149],"n=3\u20104).":[150],"In":[151],"addition,":[152],"qPCR":[153],"change":[156],"mRNA":[161],"NET":[163],"compared":[164],"untreated":[166],"controls":[167],"n=6).":[169],"Similar":[170],"results":[171],"seen":[173],"all":[175],"chambers.":[178],"Therefore,":[179],"does":[181],"not":[182],"destroy":[183],"nerve":[186],"fibers;":[187],"its":[188],"action":[189],"appears":[190],"limited":[191],"depletion":[194],"NE.":[196],"Support:":[197],"PO1HL70687.":[198]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
