{"id":"https://openalex.org/W800608472","doi":null,"title":"Mechanisms of insulin exocytosis and release","display_name":"Mechanisms of insulin exocytosis and release","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W800608472","mag":"800608472"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:1b26763f-fb4e-4459-b893-1dc4029d58ab","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/41371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001448846","display_name":"Sebastian Barg","orcid":"https://orcid.org/0000-0003-4661-5724","observed_orcids":["https://orcid.org/0000-0003-4661-5724"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sebastian Barg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4661-5724","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001448846"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-exocytosis","display_name":"insulin exocytosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/regulated-secretion","display_name":"regulated secretion","score":0.6859999895095825},{"id":"https://openalex.org/keywords/readily-releasable-pool","display_name":"readily releasable pool","score":0.7630000114440918},{"id":"https://openalex.org/keywords/reserve-pool","display_name":"reserve pool","score":0.875},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.847000002861023},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7049999833106995},{"id":"https://openalex.org/keywords/clc-3-chloride-channel","display_name":"ClC-3 chloride channel","score":0.8510000109672546},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.3659999966621399},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/granule-fusion","display_name":"granule fusion","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.9609155654907227},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.8001063466072083},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6421200037002563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5658020973205566},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5154153108596802},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4530080556869507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.426064133644104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40488263964653015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32452550530433655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3094191551208496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3023683428764343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06215152144432068},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:1b26763f-fb4e-4459-b893-1dc4029d58ab","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/41371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:800608472","doi":null,"is_oa":false,"landing_page_url":"http://lup.lub.lu.se/record/41371","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2169314089","https://openalex.org/W206530679","https://openalex.org/W1662787424","https://openalex.org/W1417364451","https://openalex.org/W2050076638","https://openalex.org/W1965002111","https://openalex.org/W7027222701","https://openalex.org/W2004564781","https://openalex.org/W7126143197","https://openalex.org/W4211227437"],"abstract_inverted_index":{"Endocrine":[0],"cells":[1],"as":[2,4,90],"well":[3],"neurons":[5],"release":[6,144,175,196],"their":[7],"hormones":[8],"and":[9,23,59,78,114,145,152,183,195,216,238,242,246,261],"transmitters":[10],"by":[11,55,232],"regulated":[12,231,265],"exocytosis.":[13],"In":[14,177],"the":[15,41,67,75,91,97,108,122,134,146,158,217,255,258,274],"pancreatic":[16],"B-cell,":[17],"stimuli":[18],"like":[19],"glucose":[20],"initiate":[21],"biochemical":[22],"electrical":[24],"processes":[25],"that":[26,124,229],"culminate":[27],"in":[28,74,110,173,197,204,270,285],"influx":[29],"of":[30,36,40,66,107,155,164,190,209,254],"Ca2+,":[31],"which":[32],"then":[33],"triggers":[34],"exocytosis":[35,81],"insulin-containing":[37],"granules.":[38],"Fusion":[39],"secretory":[42],"vesicles":[43],"occurs":[44],"rapidly":[45],"upon":[46,83],"Ca2+-influx":[47],"but":[48],"requires":[49],"a":[50,63,101,111,115,129,210,233],"granule":[51,191,240,256],"to":[52,89,142,187,279],"be":[53,280],"?primed?":[54],"an":[56],"ATP-,":[57],"Ca2+-":[58],"temperature-dependent":[60],"reaction.":[61],"Only":[62],"small":[64],"fraction":[65],"B-cell's":[68],"granules":[69,86,99,109,156],"(~":[70],"0.5":[71],"%)":[72],"are":[73,87,202,277],"primed":[76],"state":[77],"can":[79],"undergo":[80],"immediately":[82],"Ca2+-influx.":[84],"These":[85],"referred":[88],"readily":[92,116],"releasable":[93,117],"pool":[94,113,118],"(RRP),":[95],"whereas":[96],"remaining":[98],"form":[100,163],"?reserve?":[102],"pool.":[103,160],"The":[104,161,207],"functional":[105],"organization":[106],"reserve":[112,159],"could":[119],"account":[120],"for":[121,220,282],"fact":[123],"glucose-stimulated":[125],"insulin":[126,262],"secretion":[127,266,284],"follows":[128],"biphasic":[130],"time":[131],"course,":[132],"with":[133,171,257],"early":[135],"rapid":[136],"component":[137,149],"(1st":[138],"phase":[139],"secretion)":[140],"corresponding":[141],"RRP":[143],"second":[147],"slower":[148],"reflecting":[150],"time-":[151],"ATP-dependent":[153,226],"mobilization":[154],"from":[157],"commonest":[162],"human":[165],"diabetes":[166],"(type-2":[167],"diabetes)":[168],"is":[169,230,267],"associated":[170],"disturbances":[172],"this":[174,178],"pattern.":[176],"thesis,":[179],"electrophysiology,":[180],"fluorescence":[181],"microscopy":[182],"biochemistry":[184],"were":[185],"combined":[186],"explore":[188],"mechanisms":[189],"trafficking,":[192],"priming,":[193],"exocytosis,":[194],"insulin-secreting":[198],"B-cells.":[199],"Three":[200],"aspects":[201],"discussed":[203],"detail:":[205],"1)":[206],"importance":[208],"tight":[211],"interaction":[212],"between":[213,252],"L-type":[214],"Ca2+-channels":[215],"exocytotic":[218],"machinery":[219],"efficient":[221],"secretion;":[222],"2)":[223],"A":[224,248],"novel":[225],"priming":[227],"reaction":[228],"granular":[234],"65-kDa":[235],"sulfonylurea-binding":[236],"protein,":[237],"involves":[239],"acidification":[241],"ClC-3":[243],"chloride":[244],"channels;":[245],"3)":[247],"previously":[249],"overlooked":[250],"delay":[251],"fusion":[253],"plasma":[259],"membrane":[260],"release.":[263],"Since":[264],"very":[268],"similar":[269],"all":[271],"(neuro)-endocrine":[272],"cells,":[273],"data":[275],"obtained":[276],"likely":[278],"relevant":[281],"peptide":[283],"general.":[286]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}