{"id":"https://openalex.org/W80055660","doi":null,"title":"Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals.","display_name":"Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals.","publication_year":2005,"publication_date":"2005-02-25","ids":{"openalex":"https://openalex.org/W80055660","mag":"80055660","pmid":"https://pubmed.ncbi.nlm.nih.gov/15946596"},"language":"en","primary_location":{"id":"pmid:15946596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15946596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N Venkatesan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Venkatesan","raw_affiliation_strings":["K.P. College of Pharmacy, Thiruvannamalai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K.P. College of Pharmacy, Thiruvannamalai, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103294022","display_name":"Vadivu Thiyagarajan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vadivu Thiyagarajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113458758","display_name":"Sathiya Narayanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sathiya Narayanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110323734","display_name":"A. Anami Augustus Arul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arokya Arul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078138900","display_name":"Raja Sundararajan","orcid":"https://orcid.org/0000-0003-2229-6423","observed_orcids":["https://orcid.org/0000-0003-2229-6423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sundararajan Raja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056799219","display_name":"Sengodan Gurusamy Vijaya Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sengodan Gurusamy Vijaya Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013621672","display_name":"Thandavarayan Rajarajan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thandavarayan Rajarajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046358628","display_name":"James B. Perianayagam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Britto Perianayagam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.831,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.97267796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"39","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asparagus-racemosus","display_name":"Asparagus racemosus","score":1.0},{"id":"https://openalex.org/keywords/antidiarrheal-activity","display_name":"antidiarrheal activity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8429999947547913},{"id":"https://openalex.org/keywords/castor-oil-induced-diarrhea","display_name":"castor oil-induced diarrhea","score":0.9079999923706055},{"id":"https://openalex.org/keywords/enteropooling","display_name":"enteropooling","score":0.921999990940094},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.9739999771118164},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6349999904632568},{"id":"https://openalex.org/keywords/ayurveda","display_name":"Ayurveda","score":0.9779999852180481},{"id":"https://openalex.org/keywords/root-extract","display_name":"root extract","score":0.7559999823570251},{"id":"https://openalex.org/keywords/aqueous-and-ethanol-extracts","display_name":"aqueous and ethanol extracts","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778814440","wikidata":"https://www.wikidata.org/wiki/Q2742649","display_name":"Antidiarrhoeal","level":3,"score":0.9372714757919312},{"id":"https://openalex.org/C2778223594","wikidata":"https://www.wikidata.org/wiki/Q4807702","display_name":"Asparagus racemosus","level":3,"score":0.8893175721168518},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7309629321098328},{"id":"https://openalex.org/C2777573665","wikidata":"https://www.wikidata.org/wiki/Q423751","display_name":"Loperamide","level":3,"score":0.6071498990058899},{"id":"https://openalex.org/C2778229996","wikidata":"https://www.wikidata.org/wiki/Q337492","display_name":"Castor oil","level":2,"score":0.5438490509986877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41303640604019165},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.4113119840621948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37421029806137085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3643531799316406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3518720269203186},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.2881675362586975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23405462503433228},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.2083221673965454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07141992449760437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000930","descriptor_name":"Antidiarrheals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027761","descriptor_name":"Asparagus Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15946596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15946596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.577.9481","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.577.9481","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ualberta.ca/~csps/JPPS8(1)/J.Perianayagam/asparagus.pdf","raw_type":"text"},{"id":"mag:80055660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15946596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W365713858","https://openalex.org/W571572828","https://openalex.org/W1490202469","https://openalex.org/W1504183124","https://openalex.org/W1511454777","https://openalex.org/W1578807278","https://openalex.org/W1620485062","https://openalex.org/W1970182011","https://openalex.org/W1970277212","https://openalex.org/W1996171980","https://openalex.org/W1997020418","https://openalex.org/W2000484513","https://openalex.org/W2008364158","https://openalex.org/W2009985331","https://openalex.org/W2018451712","https://openalex.org/W2023417128","https://openalex.org/W2027410314","https://openalex.org/W2027877938","https://openalex.org/W2035164859","https://openalex.org/W2038462428","https://openalex.org/W2049187923","https://openalex.org/W2051807918","https://openalex.org/W2052259733","https://openalex.org/W2052586356","https://openalex.org/W2056128097","https://openalex.org/W2059767624","https://openalex.org/W2059805912","https://openalex.org/W2060937181","https://openalex.org/W2073575825","https://openalex.org/W2076279918","https://openalex.org/W2081197670","https://openalex.org/W2089421172","https://openalex.org/W2093508570","https://openalex.org/W2104224297","https://openalex.org/W2207382912","https://openalex.org/W2737272531"],"related_works":["https://openalex.org/W7096467887","https://openalex.org/W2113171893","https://openalex.org/W2023417128","https://openalex.org/W2290270291","https://openalex.org/W2592401510","https://openalex.org/W3015046097","https://openalex.org/W2419212150","https://openalex.org/W2088420268","https://openalex.org/W2398937566","https://openalex.org/W1964940245"],"abstract_inverted_index":{"PURPOSE:":[0],"Asparagus":[1,48,74],"racemosus":[2,49,75],"Wild":[3],"root":[4,76],"has":[5],"been":[6],"used":[7,113],"traditionally":[8],"in":[9,60,84,137,153,156,160,189],"Ayurveda":[10,22],"for":[11,50,187],"the":[12,19,33,40,89,167,172,177],"treatment":[13,186],"of":[14,21,42,47,58,68,73,91,171,179],"diarrhoea":[15,59,82,132,188],"and":[16,44,70,93,104,133,175],"dysentery.":[17],"However,":[18],"claims":[20],"need":[23],"to":[24,38],"be":[25],"validated":[26],"by":[27],"a":[28,184],"suitable":[29],"experimental":[30,56],"model.":[31],"Therefore,":[32],"present":[34],"study":[35],"was":[36,77,112],"undertaken":[37],"evaluate":[39],"effect":[41,90,170],"ethanol":[43,69,92],"aqueous":[45,71,94],"extracts":[46,72,95,120,145,174],"its":[51],"antidiarrhoeal":[52,66],"potential":[53],"against":[54,128],"several":[55],"models":[57],"Albino":[61],"Wistar":[62],"rats.":[63,85,161],"METHODS:":[64],"The":[65,118,163],"activity":[67,127],"evaluated":[78,88],"using":[79],"castor":[80,129],"oil-induced":[81],"model":[83],"Further,":[86],"we":[87],"on":[96],"gastrointestinal":[97,154],"tract":[98],"motility":[99,155],"after":[100],"charcoal":[101,157],"meal":[102,158],"administration":[103],"PGE2":[105,134],"induced":[106,131,135],"intestinal":[107],"fluid":[108],"accumulation":[109],"(enteropooling).":[110],"Loperamide":[111],"as":[114,183],"positive":[115],"control.":[116],"RESULTS:":[117],"plant":[119,173],"showed":[121,147],"significant":[122,148],"(P":[123,149],"<":[124,150],"0.05)":[125],"inhibitor":[126],"oil":[130],"enteropooling":[136],"rats":[138],"when":[139],"tested":[140],"at":[141],"200":[142],"mg/kg.":[143],"Both":[144],"also":[146],"0.001)":[151],"reduction":[152],"test":[159],"CONCLUSION:":[162],"results":[164],"point":[165],"out":[166],"possible":[168],"anti-diarrhoeal":[169],"substantiate":[176],"use":[178],"this":[180],"herbal":[181],"remedy":[182],"non-specific":[185],"folk":[190],"medicine.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}