{"id":"https://openalex.org/W80052973","doi":"https://doi.org/10.1007/s00228-002-0529-3","title":"CYP2D6*10 alleles do not determine plasma fluvoxamine concentration/dose ratio in Japanese subjects","display_name":"CYP2D6*10 alleles do not determine plasma fluvoxamine concentration/dose ratio in Japanese subjects","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W80052973","doi":"https://doi.org/10.1007/s00228-002-0529-3","mag":"80052973","pmid":"https://pubmed.ncbi.nlm.nih.gov/12610741"},"language":"en","primary_location":{"id":"doi:10.1007/s00228-002-0529-3","doi":"https://doi.org/10.1007/s00228-002-0529-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-002-0529-3","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112156782","display_name":"Koichi Ohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koichi Ohara","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan. kohara@shanamaki.hosp.go.jp","Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan. kohara@shanamaki.hosp.go.jp","institution_ids":["https://openalex.org/I4210130763"]},{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050037209","display_name":"Shigeru Tanabu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Tanabu","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuhisa Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhisa Ishibashi","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074375654","display_name":"Keiko Ikemoto","orcid":"https://orcid.org/0009-0003-5731-8845","observed_orcids":["https://orcid.org/0009-0003-5731-8845"]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Ikemoto","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045729343","display_name":"Kimiko Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiko Yoshida","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111711976","display_name":"Haruo Shibuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130763","display_name":"National Hospital Organization Hanamaki Hospital","ror":"https://ror.org/03d6stm02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130763","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruo Shibuya","raw_affiliation_strings":["Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan,","institution_ids":["https://openalex.org/I4210130763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112156782"],"corresponding_institution_ids":["https://openalex.org/I4210130763"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.361,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.53473726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"10","first_page":"659","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6-10-allele","display_name":"CYP2D6*10 allele","score":0.843999981880188},{"id":"https://openalex.org/keywords/fluvoxamine","display_name":"fluvoxamine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cyp2d6-polymorphism","display_name":"CYP2D6 polymorphism","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7120000123977661},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.6140000224113464},{"id":"https://openalex.org/keywords/ethnic-differences-in-drug-metabolism","display_name":"ethnic differences in drug metabolism","score":0.6570000052452087},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.8200101852416992},{"id":"https://openalex.org/C2779910183","wikidata":"https://www.wikidata.org/wiki/Q409236","display_name":"Fluvoxamine","level":5,"score":0.7896119356155396},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6537540555000305},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6523860692977905},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6430850028991699},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5473081469535828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.413652241230011},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3876708745956421},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37990352511405945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27471834421157837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2149866223335266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11813879013061523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05504268407821655},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.05332329869270325},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016666","descriptor_name":"Fluvoxamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016666","descriptor_name":"Fluvoxamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00228-002-0529-3","doi":"https://doi.org/10.1007/s00228-002-0529-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-002-0529-3","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:12610741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12610741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1588051127","https://openalex.org/W1630545408","https://openalex.org/W1785435186","https://openalex.org/W1785901044","https://openalex.org/W1970846917","https://openalex.org/W1982636446","https://openalex.org/W1990912030","https://openalex.org/W2020448861","https://openalex.org/W2031775036","https://openalex.org/W2039848755","https://openalex.org/W2040194216","https://openalex.org/W2060473370","https://openalex.org/W2077369103","https://openalex.org/W2090628258","https://openalex.org/W2094263944","https://openalex.org/W2116318788","https://openalex.org/W2156412357"],"related_works":["https://openalex.org/W1982611012","https://openalex.org/W2011444941","https://openalex.org/W2084743004","https://openalex.org/W3012358180","https://openalex.org/W3112570172","https://openalex.org/W2039848755","https://openalex.org/W1488321941","https://openalex.org/W2108681829","https://openalex.org/W2007404873","https://openalex.org/W2388572940"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}