{"id":"https://openalex.org/W800401568","doi":"https://doi.org/10.1007/s40778-015-0020-6","title":"The Role of Stem Cell Genomic Instability in Aging","display_name":"The Role of Stem Cell Genomic Instability in Aging","publication_year":2015,"publication_date":"2015-06-25","ids":{"openalex":"https://openalex.org/W800401568","doi":"https://doi.org/10.1007/s40778-015-0020-6","mag":"800401568"},"language":"en","primary_location":{"id":"doi:10.1007/s40778-015-0020-6","doi":"https://doi.org/10.1007/s40778-015-0020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-015-0020-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-015-0020-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-015-0020-6.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042406494","display_name":"Cynthia J. Sieben","orcid":"https://orcid.org/0000-0002-6733-7711","observed_orcids":["https://orcid.org/0000-0002-6733-7711"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J. Hommerding","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011169178","display_name":"Bennett G. Childs","orcid":"https://orcid.org/0000-0001-6078-0588","observed_orcids":["https://orcid.org/0000-0001-6078-0588"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett G. Childs","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081893956","display_name":"Darren J. Baker","orcid":"https://orcid.org/0000-0001-9006-1939","observed_orcids":["https://orcid.org/0000-0001-9006-1939"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darren J. Baker","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA","Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081893956"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0171907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"3","first_page":"151","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8309999704360962},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9330000281333923},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.8960512280464172},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8166446685791016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6873824596405029},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.6821948289871216},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6130607724189758},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5394559502601624},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.44940489530563354},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.41968652606010437},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.41754862666130066},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3625391125679016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3051181435585022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1410827338695526},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13302186131477356},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.1193864643573761}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40778-015-0020-6","doi":"https://doi.org/10.1007/s40778-015-0020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-015-0020-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-015-0020-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40778-015-0020-6","doi":"https://doi.org/10.1007/s40778-015-0020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-015-0020-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-015-0020-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W800401568.pdf","grobid_xml":"https://content.openalex.org/works/W800401568.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W126539919","https://openalex.org/W239602587","https://openalex.org/W1493263872","https://openalex.org/W1508556872","https://openalex.org/W1538419182","https://openalex.org/W1541877559","https://openalex.org/W1612842202","https://openalex.org/W1964551999","https://openalex.org/W1965730026","https://openalex.org/W1966228034","https://openalex.org/W1967064280","https://openalex.org/W1968796569","https://openalex.org/W1970338621","https://openalex.org/W1971100182","https://openalex.org/W1976996876","https://openalex.org/W1977465540","https://openalex.org/W1979765208","https://openalex.org/W1980052833","https://openalex.org/W1981775109","https://openalex.org/W1982763980","https://openalex.org/W1983673827","https://openalex.org/W1984187829","https://openalex.org/W1988280121","https://openalex.org/W1994767653","https://openalex.org/W1995146769","https://openalex.org/W1995365852","https://openalex.org/W1996002936","https://openalex.org/W1998004606","https://openalex.org/W2004314923","https://openalex.org/W2007441754","https://openalex.org/W2016774587","https://openalex.org/W2017117976","https://openalex.org/W2017632960","https://openalex.org/W2021050536","https://openalex.org/W2021264577","https://openalex.org/W2021488377","https://openalex.org/W2022507419","https://openalex.org/W2022527641","https://openalex.org/W2036265947","https://openalex.org/W2040830133","https://openalex.org/W2041036994","https://openalex.org/W2041897873","https://openalex.org/W2043118962","https://openalex.org/W2044512053","https://openalex.org/W2046589688","https://openalex.org/W2047330128","https://openalex.org/W2049462421","https://openalex.org/W2050513874","https://openalex.org/W2054079671","https://openalex.org/W2054165069","https://openalex.org/W2054460914","https://openalex.org/W2054632418","https://openalex.org/W2058097237","https://openalex.org/W2058647415","https://openalex.org/W2065564965","https://openalex.org/W2066442023","https://openalex.org/W2066844712","https://openalex.org/W2067028731","https://openalex.org/W2068409711","https://openalex.org/W2068419083","https://openalex.org/W2069519394","https://openalex.org/W2070618839","https://openalex.org/W2073429636","https://openalex.org/W2075216292","https://openalex.org/W2078003979","https://openalex.org/W2078435477","https://openalex.org/W2081067390","https://openalex.org/W2084233122","https://openalex.org/W2084289371","https://openalex.org/W2085387059","https://openalex.org/W2087239831","https://openalex.org/W2088261700","https://openalex.org/W2091267003","https://openalex.org/W2091413140","https://openalex.org/W2092015913","https://openalex.org/W2094375019","https://openalex.org/W2100436127","https://openalex.org/W2108043548","https://openalex.org/W2108116044","https://openalex.org/W2111920812","https://openalex.org/W2112365416","https://openalex.org/W2116043907","https://openalex.org/W2119506861","https://openalex.org/W2130458932","https://openalex.org/W2130935375","https://openalex.org/W2132606465","https://openalex.org/W2133959309","https://openalex.org/W2136315377","https://openalex.org/W2137790111","https://openalex.org/W2142205521","https://openalex.org/W2142325519","https://openalex.org/W2145578278","https://openalex.org/W2148479228","https://openalex.org/W2158491040","https://openalex.org/W2160740947","https://openalex.org/W2167829409","https://openalex.org/W2169160857","https://openalex.org/W2170321545","https://openalex.org/W2171317581","https://openalex.org/W2603580982"],"related_works":["https://openalex.org/W2054525725","https://openalex.org/W2999332252","https://openalex.org/W3037190600","https://openalex.org/W1977465540","https://openalex.org/W2403657748","https://openalex.org/W2049544435","https://openalex.org/W856695000","https://openalex.org/W2063062036","https://openalex.org/W2136315377","https://openalex.org/W2766158258"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}