{"id":"https://openalex.org/W80004777","doi":"https://doi.org/10.1182/blood.v92.2.704","title":"The Prothrombin G20210A Mutation and Factor V Leiden Mutation in Patients With Cerebrovascular Disease","display_name":"The Prothrombin G20210A Mutation and Factor V Leiden Mutation in Patients With Cerebrovascular Disease","publication_year":1998,"publication_date":"1998-07-15","ids":{"openalex":"https://openalex.org/W80004777","doi":"https://doi.org/10.1182/blood.v92.2.704","mag":"80004777","pmid":"https://pubmed.ncbi.nlm.nih.gov/9657778"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v92.2.704","doi":"https://doi.org/10.1182/blood.v92.2.704","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.2.704","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109241836","display_name":"Wolfgang Lalouschek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Lalouschek","raw_affiliation_strings":["University Clinic for Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032912365","display_name":"Susanne Aull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanne Aull","raw_affiliation_strings":["University Clinic for Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056283317","display_name":"Wolfgang Series","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Series","raw_affiliation_strings":["University Clinic for Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035124876","display_name":"Karl Zeiler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl Zeiler","raw_affiliation_strings":["University Clinic for Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic for Neurology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070752127","display_name":"Christine Mannhalter","orcid":"https://orcid.org/0000-0001-7667-8078","observed_orcids":["https://orcid.org/0000-0001-7667-8078"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christine Mannhalter","raw_affiliation_strings":["Department of Laboratory Medicine Molecular Biology Division University Vienna Medical School Vienna, Austria","Department of Laboratory Medicine","Molecular Biology Division","University Clinic for Neurology","University Vienna Medical School","Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine Molecular Biology Division University Vienna Medical School Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Laboratory Medicine","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Division","institution_ids":[]},{"raw_affiliation_string":"University Clinic for Neurology","institution_ids":[]},{"raw_affiliation_string":"University Vienna Medical School","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]},{"raw_affiliation_string":"Vienna, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.3922,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79159465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"92","issue":"2","first_page":"704","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prothrombin-g20210a-mutation","display_name":"prothrombin G20210A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8529999852180481},{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.7099999785423279},{"id":"https://openalex.org/keywords/genetic-predisposition-to-thrombosis","display_name":"genetic predisposition to thrombosis","score":0.75},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.694227933883667},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.6683807373046875},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.6219398975372314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5256370306015015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4710761606693268},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46213498711586},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.41494375467300415},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.41152307391166687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3907335102558136},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.28505486249923706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28397083282470703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2819654047489166},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.26107197999954224},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v92.2.704","doi":"https://doi.org/10.1182/blood.v92.2.704","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.2.704","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v92.2.704.spll6_704_705","doi":"https://doi.org/10.1182/blood.v92.2.704.spll6_704_705","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v92.2.704.spll6_704_705","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9657778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9657778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1485388354","https://openalex.org/W1531281563","https://openalex.org/W1985517420","https://openalex.org/W1992127247","https://openalex.org/W2040572522","https://openalex.org/W2125480116","https://openalex.org/W2163474339","https://openalex.org/W2339305503","https://openalex.org/W2404865726","https://openalex.org/W2407616654","https://openalex.org/W2408270223","https://openalex.org/W2409417821","https://openalex.org/W2410509689","https://openalex.org/W2469292178","https://openalex.org/W2610686450"],"related_works":["https://openalex.org/W2802119608","https://openalex.org/W146706857","https://openalex.org/W2765362111","https://openalex.org/W2748637180","https://openalex.org/W4213248460","https://openalex.org/W1964867773","https://openalex.org/W4245742546","https://openalex.org/W2753133937","https://openalex.org/W3214246029","https://openalex.org/W2132373150"],"abstract_inverted_index":{"To":[0],"the":[1,26,40],"Editor:\n\nGenetic":[2],"variants":[3],"leading":[4],"to":[5,12,19,37],"a":[6,47],"persistent":[7],"hypercoagulable":[8],"state":[9],"may":[10],"predispose":[11],"thrombotic":[13],"events.":[14],"A":[15,20],"recently":[16],"discovered":[17],"G":[18],"mutation":[21],"at":[22],"position":[23],"1691":[24],"of":[25,39],"factor":[27],"V":[28,31],"gene":[29],"(factor":[30],"Leiden":[32],"mutation),":[33],"occurring":[34],"in":[35],"3%":[36],"5%":[38],"normal":[41],"Caucasian":[42],"population,":[43],"has":[44],"emerged":[45],"as":[46],"major":[48]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}