{"id":"https://openalex.org/W79942919","doi":null,"title":"Purified colicin as cytotoxic agent of neoplasia: comparative study with crude colicin.","display_name":"Purified colicin as cytotoxic agent of neoplasia: comparative study with crude colicin.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W79942919","mag":"79942919","pmid":"https://pubmed.ncbi.nlm.nih.gov/3891240"},"language":"en","primary_location":{"id":"pmid:3891240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3891240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytobios","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069399459","display_name":"Hannah Farkas-Himsley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Farkas-Himsley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"H Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3026,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.5082093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"167-168","first_page":"193","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.4133000075817108,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.4133000075817108,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.20630000531673431,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colicins","display_name":"colicins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bacteriocin-purification","display_name":"bacteriocin purification","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dna-loss","display_name":"DNA loss","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mammalian-cell-toxicity","display_name":"mammalian cell toxicity","score":0.5139999985694885},{"id":"https://openalex.org/keywords/bacterial-growth-inhibition","display_name":"bacterial growth inhibition","score":0.9350000023841858},{"id":"https://openalex.org/keywords/3h-thymidine-uptake","display_name":"3H-thymidine uptake","score":0.7409999966621399},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.5830000042915344},{"id":"https://openalex.org/keywords/polypeptide-structure","display_name":"polypeptide structure","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C168707992","wikidata":"https://www.wikidata.org/wiki/Q15439223","display_name":"Colicin","level":4,"score":0.9972174167633057},{"id":"https://openalex.org/C115574571","wikidata":"https://www.wikidata.org/wiki/Q183119","display_name":"Bacteriocin","level":3,"score":0.9520426392555237},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7379137277603149},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5707337260246277},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.5365616679191589},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5328220725059509},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5269948840141296},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4984149932861328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49709275364875793},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4684857130050659},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46335792541503906},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.4177601635456085},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4099385142326355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3822808563709259},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3814729154109955},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3131346106529236},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.22495603561401367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07053941488265991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003087","descriptor_name":"Colicins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003087","descriptor_name":"Colicins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003087","descriptor_name":"Colicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3891240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3891240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytobios","raw_type":"Comparative Study"},{"id":"mag:79942919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3891240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091452959","https://openalex.org/W4362736113","https://openalex.org/W2053463308","https://openalex.org/W843627249","https://openalex.org/W7216676500","https://openalex.org/W1594775465","https://openalex.org/W2096548924","https://openalex.org/W2297125853","https://openalex.org/W2080493648","https://openalex.org/W1654617960"],"abstract_inverted_index":{"Purification":[0],"of":[1,29,34,89,123,126,134],"a":[2,26,45,48],"bacteriocin,":[3],"colicin,":[4],"from":[5,44,78,97],"Escherichia":[6],"coli":[7],"HSC10,":[8],"is":[9,51],"described.":[10],"A":[11,53],"1,800":[12],"fold":[13],"purified":[14],"colicin":[15,35,128],"was":[16,71,102],"obtained":[17,114],"and":[18,38,60,87,147,152,158],"found":[19,140],"to":[20,47,105,115,130,141],"be":[21],"an":[22],"acidic":[23],"polypeptide":[24],"with":[25,85],"molecular":[27],"weight":[28],"82,000":[30],"daltons.":[31],"The":[32,137],"effect":[33,67],"on":[36,68],"bacterial":[37,57,157],"mammalian":[39,69,81,100,159],"cells":[40],"during":[41],"the":[42,66,79,98,107,135],"transition":[43],"crude":[46,151],"pure":[49,127,153],"preparation":[50],"given.":[52],"turbidimetric":[54],"assay":[55],"for":[56,64],"growth":[58],"inhibition":[59,63],"3H-thymidine":[61,118],"uptake":[62,119],"measuring":[65],"cells,":[70,82,101],"used.":[72],"Colicin":[73],"HSC10":[74],"caused":[75],"DNA":[76,95],"loss":[77,96],"bacteriocin-sensitive":[80],"which":[83,93],"increased":[84],"dose":[86],"time":[88],"exposure.":[90],"Therefore,":[91],"flow-cytometry,":[92],"detects":[94],"bacteriocin-affected":[99],"also":[103],"used":[104],"evaluate":[106],"bacteriocin":[108],"potency.":[109],"Similar":[110],"quantitative":[111],"results":[112],"were":[113,139],"those":[116],"using":[117],"inhibition,":[120],"in":[121],"terms":[122],"microgram":[124],"protein":[125],"required":[129],"affect":[131],"adversely":[132],"50%":[133],"cells.":[136,160],"bacteriocins":[138],"retain":[142],"their":[143],"activity":[144],"following":[145],"freezing":[146],"thawing,":[148],"both":[149,156],"as":[150],"preparations,":[154],"against":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
