{"id":"https://openalex.org/W799267243","doi":"https://doi.org/10.5352/jls.2009.19.3.403","title":"Effects of Treadmill Exercise on Memory, Hippocampal Cell Proliferation, BDNF, TrkB, and Forebrain Cholinergic Cells in Adolescent Rats","display_name":"Effects of Treadmill Exercise on Memory, Hippocampal Cell Proliferation, BDNF, TrkB, and Forebrain Cholinergic Cells in Adolescent Rats","publication_year":2009,"publication_date":"2009-03-31","ids":{"openalex":"https://openalex.org/W799267243","doi":"https://doi.org/10.5352/jls.2009.19.3.403","mag":"799267243"},"language":"en","primary_location":{"id":"doi:10.5352/jls.2009.19.3.403","doi":"https://doi.org/10.5352/jls.2009.19.3.403","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2009.19.3.403","pdf_url":"http://koreascience.or.kr:80/article/JAKO200912651520386.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO200912651520386.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062086434","display_name":"Hee\u2010Hyuk Lee","orcid":"https://orcid.org/0000-0001-5757-2104","observed_orcids":["https://orcid.org/0000-0001-5757-2104"]},"institutions":[{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Lee, Hee-Hyuk;","raw_affiliation_strings":["Department of Sports Science , Hannam University , Daejeon 306-791 , Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sports Science , Hannam University , Daejeon 306-791 , Korea","institution_ids":["https://openalex.org/I112728665"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062086434"],"corresponding_institution_ids":["https://openalex.org/I112728665"],"apc_list":null,"apc_paid":null,"fwci":0.0975,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47821012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"19","issue":"3","first_page":"403","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-rats","display_name":"adolescent rats","score":0.6790000200271606},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.6190000176429749},{"id":"https://openalex.org/keywords/memory-enhancement","display_name":"memory enhancement","score":0.3869999945163727},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.39100000262260437},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.3089999854564667},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.9635701179504395},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6896457672119141},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6717469692230225},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6079198122024536},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5953188538551331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5860733985900879},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5764902830123901},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.5291332006454468},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5257759094238281},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4886167645454407},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4217085838317871},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37894198298454285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.313944548368454},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09854570031166077},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09545767307281494}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5352/jls.2009.19.3.403","doi":"https://doi.org/10.5352/jls.2009.19.3.403","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2009.19.3.403","pdf_url":"http://koreascience.or.kr:80/article/JAKO200912651520386.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},{"id":"mag:1654746836","doi":null,"is_oa":false,"landing_page_url":"https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE01162054","pdf_url":null,"source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\uc0dd\uba85\uacfc\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":{"id":"doi:10.5352/jls.2009.19.3.403","doi":"https://doi.org/10.5352/jls.2009.19.3.403","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2009.19.3.403","pdf_url":"http://koreascience.or.kr:80/article/JAKO200912651520386.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W799267243.pdf","grobid_xml":"https://content.openalex.org/works/W799267243.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W182877123","https://openalex.org/W761807580","https://openalex.org/W1670625131","https://openalex.org/W1964644228","https://openalex.org/W1969854375","https://openalex.org/W1983706324","https://openalex.org/W1985645068","https://openalex.org/W1992694866","https://openalex.org/W1992790917","https://openalex.org/W1993109188","https://openalex.org/W1995188451","https://openalex.org/W2002161951","https://openalex.org/W2003972991","https://openalex.org/W2005805321","https://openalex.org/W2005940536","https://openalex.org/W2006653627","https://openalex.org/W2009030299","https://openalex.org/W2021551531","https://openalex.org/W2025288365","https://openalex.org/W2026472945","https://openalex.org/W2040072583","https://openalex.org/W2045309216","https://openalex.org/W2053326179","https://openalex.org/W2055503718","https://openalex.org/W2057070563","https://openalex.org/W2059981865","https://openalex.org/W2060986800","https://openalex.org/W2061238653","https://openalex.org/W2066934210","https://openalex.org/W2067856703","https://openalex.org/W2070648258","https://openalex.org/W2071804866","https://openalex.org/W2072360085","https://openalex.org/W2074620251","https://openalex.org/W2075404405","https://openalex.org/W2078553163","https://openalex.org/W2078945917","https://openalex.org/W2089178573","https://openalex.org/W2091927578","https://openalex.org/W2099867701","https://openalex.org/W2100464372","https://openalex.org/W2102060609","https://openalex.org/W2111443630","https://openalex.org/W2115565337","https://openalex.org/W2120095635","https://openalex.org/W2140112919","https://openalex.org/W2156480905","https://openalex.org/W2160392194","https://openalex.org/W2166602438","https://openalex.org/W2167194856"],"related_works":["https://openalex.org/W1654746836","https://openalex.org/W7083181600","https://openalex.org/W2125764464","https://openalex.org/W3179121143","https://openalex.org/W2299583812","https://openalex.org/W3127384861","https://openalex.org/W2268414058","https://openalex.org/W2355537562","https://openalex.org/W3190600414","https://openalex.org/W2159756187"],"abstract_inverted_index":{"\ubcf8":[0],"\uc5f0\uad6c\ub294":[1],"\uccad\uc18c\ub144\uae30":[2,86],"\ud770\uc950\ub97c":[3],"\ub300\uc0c1\uc73c\ub85c":[4],"4\uc8fc\uac04\uc758":[5],"\uc800\uac15\ub3c4":[6],"\ud2b8\ub808\ub4dc\ubc00":[7],"\uc6b4\ub3d9\uc774":[8,22,87],"\uae30\uc5b5\ub825\uacfc":[9],"\ud574\ub9c8":[10,76],"\uc2e0\uacbd\uc138\ud3ec\uc0dd\uc131,":[11],"BDNF,":[12,109],"Trkb,":[13],"\uc911\uaca9":[14],"\ucf5c\ub9b0\uc138\ud3ec\uc5d0":[15],"\ubbf8\uce58\ub294":[16,24],"\ud6a8\uacfc\ub97c":[17,25],"\uc870\uc0ac\ud558\uae30":[18],"\uc704\ud558\uc5ec":[19],"\uc218\ud589\ub418\uc5c8\ub2e4.":[20],"\uba3c\uc800":[21],"\uae30\uc5b5\ub825\uc5d0":[23],"step-through":[26,171],"avoidance\uc5d0\uc11c":[27],"\uac80\uc0ac\ud55c":[28],"\uacb0\uacfc":[29],"\uc6b4\ub3d9\uc744":[30,70],"\uc2e4\uc2dc\ud588\ub358":[31],"\ud770\uc950\uc758":[32],"retention":[33],"latency\uac00":[34],"\ub300\uc870\uad70\uc5d0":[35,63],"\ube44\ud574":[36,64],"\uc720\uc758\ud558\uac8c":[37,65],"\uc99d\uac00\ub418\uc5b4":[38],"\uae30\uc5b5\ub825":[39,43,88],"\ud5a5\uc0c1\uc744":[40],"\ub098\ud0c0\ub0b4\uc5c8\ub2e4.":[41],"\uc774\ud6c4":[42],"\ud5a5\uc0c1\uae30\uc804\uc73c\ub85c":[44],"\ud574\ub9c8\uc5d0\uc11c":[45],"\uc2e0\uacbd\uc138\ud3ec\uc99d\uc2dd\uacfc":[46],"BDNF":[47,78,230],"\ubc0f":[48],"TrkB":[49,59,111,232],"\ub2e8\ubc31\uc9c8":[50,60],"\ubc1c\ud604\uc744":[51],"\uc815\ub7c9\ud654":[52],"\ud55c":[53],"\uacb0\uacfc\uc5d0\uc11c\ub3c4":[54],"\uc6b4\ub3d9\uad70\uc758":[55],"\uc2e0\uacbd\uc138\ud3ec":[56],"\uc0dd\uc131\uc728\uacfc":[57],"BDNF\uc640":[58],"\ubc1c\ud604":[61,79],"\ubaa8\ub450":[62],"\uc99d\uac00\ub41c":[66],"\uac83\uc73c\ub85c":[67,82],"\ub098\ud0c0\ub0ac\ub2e4.":[68,83],"\uac8c\ub2e4\uac00":[69],"\ud1b5\ud55c":[71],"\uc804\ub1cc":[72],"\ucf5c\ub9b0\uc138\ud3ec":[73],"\uc218\uc758":[74],"\uc99d\uac00\uac00":[75],"\uc2e0\uacbd\uc138\ud3ec\uc0dd\uc131\uacfc":[77],"\uc99d\uac00\uc5d0":[80],"\uae30\uc5ec\ud558\ub294":[81],"\uc774\ub7ec\ud55c":[84],"\uacb0\uacfc\ub294":[85],"\ud5a5\uc0c1\uc5d0":[89],"\ub3c4\uc6c0\uc774":[90],"\ub420":[91],"\uc218":[92],"\uc788\uc74c\uc744":[93],"\ubcf4\uc5ec\uc8fc\ub294":[94],"\uac83\uc774\ub2e4.":[95],"This":[96],"study":[97,211],"investigated":[98],"the":[99,113,132,136,141,147,170,217,236,249],"effects":[100],"of":[101,169,238],"treadmill":[102,156,214],"exercise":[103,142,148,247],"on":[104,154],"memory":[105,180,222,254],"ability,":[106],"cell":[107,199,226],"proliferation,":[108,227],"and":[110,115,140,187,201,231,234],"in":[112,119,146,176],"hippocampus":[114],"forebrain":[116,202,239],"cholinergic":[117,203,240],"cells":[118,204],"adolescent":[120,218,250],"rats.":[121],"Male":[122],"Sprague-Dawley":[123],"rats":[124],"(4":[125],"weeks":[126],"old)":[127],"were":[128,150,193,205],"randomly":[129],"assigned":[130],"to":[131,152,178],"following":[133],"two":[134],"groups:":[135],"sedentary":[137],"group":[138,143,149],"(n=10)":[139],"(n=10).":[144],"Rats":[145],"forced":[151],"run":[153],"a":[155],"for":[157,164],"30":[158],"min,":[159],"five":[160],"times":[161],"per":[162],"week":[163],"4":[165],"weeks.":[166],"The":[167,209],"latency":[168],"avoidance":[172],"task":[173],"was":[174],"used":[175],"order":[177],"evaluate":[179],"ability.":[181],"Hippocampal":[182,198],"brain-derived":[183],"neurotrophic":[184],"factor":[185],"(BDNF)":[186],"tropomyosin-related":[188],"kinase":[189],"B":[190],"(TrkB)":[191],"expression":[192],"assessed":[194,206],"by":[195,207],"Western":[196],"blotting.":[197],"proliferation":[200],"immunohistochemistry.":[208],"present":[210],"showed":[212],"that":[213,245],"running":[215],"during":[216,248],"period":[219,251],"significantly":[220],"improved":[221],"capability,":[223],"increased":[224],"hippocampal":[225,229],"up-regulated":[228],"expression,":[233],"enhanced":[235],"number":[237],"cells.":[241],"These":[242],"results":[243],"suggest":[244],"regular":[246],"may":[252],"enhance":[253],"function.":[255]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
