{"id":"https://openalex.org/W79896775","doi":null,"title":"Measurement and possible function of GnRH in cerebrospinal fluid in ewes.","display_name":"Measurement and possible function of GnRH in cerebrospinal fluid in ewes.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W79896775","mag":"79896775","pmid":"https://pubmed.ncbi.nlm.nih.gov/12698971"},"language":"en","primary_location":{"id":"pmid:12698971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12698971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England). Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112205931","display_name":"Donal C. Skinner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D C Skinner","raw_affiliation_strings":["Department of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, UK. dcs@uwyo.edu","Department of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, UK. dcs@uwyo.edu","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110345395","display_name":"Alain Caraty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Caraty","raw_affiliation_strings":["University of Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":null,"apc_paid":null,"fwci":0.6699,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.64818068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"59","issue":"suppl.","first_page":"25","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ewes","display_name":"ewes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/sexual-behavior","display_name":"sexual behavior","score":0.6959999799728394},{"id":"https://openalex.org/keywords/intracerebroventricular-infusion","display_name":"intracerebroventricular infusion","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8985617160797119},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.47527068853378296},{"id":"https://openalex.org/C2780066322","wikidata":"https://www.wikidata.org/wiki/Q719444","display_name":"Lumbar puncture","level":3,"score":0.45490536093711853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45230984687805176},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4368031620979309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41688451170921326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39849376678466797},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.368306964635849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3632173240184784}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030762","descriptor_name":"Estrous Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12698971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12698971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England). Supplement","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02678713v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02678713","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reproduction [Cambridge]. Supplement, 2002, 59 (suppl.), pp.25-39","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02827716v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02827716","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"8. International Theriological Congress, Aug 2001, Sun City, South Africa","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036631779","https://openalex.org/W2138483584","https://openalex.org/W2132372976","https://openalex.org/W2049492989","https://openalex.org/W2021364293","https://openalex.org/W2171353949","https://openalex.org/W2095058211","https://openalex.org/W2103700559","https://openalex.org/W1530058557","https://openalex.org/W7049089069"],"abstract_inverted_index":{"Large":[0],"mammal":[1],"models":[2],"are":[3,119],"unique":[4],"in":[5,24,50,79,108,116,134,174,185,218,220],"that":[6,99,114,148,172,205],"it":[7],"is":[8,55,112,126,150,168,207],"possible":[9],"to":[10,141],"analyse":[11],"the":[12,36,61,104,109,117,129,158,161,186],"real-time":[13],"release":[14],"of":[15,46,76,106,131,155,180],"neural":[16],"factors":[17,115,156,173,194],"over":[18],"several":[19],"hours":[20],"or":[21,88],"even":[22],"days":[23],"a":[25,132,181,211],"conscious":[26],"unstressed":[27],"state.":[28],"Until":[29],"recently,":[30],"hypophyseal":[31,90,162],"portal":[32,91,163],"blood":[33,92],"sampling":[34],"was":[35],"only":[37],"reliable":[38],"method":[39],"available":[40],"for":[41,192,213],"this":[42,77,124],"purpose.":[43],"However,":[44,202],"development":[45],"an":[47,189],"alternative":[48],"approach,":[49,78],"which":[51,69],"cerebrospinal":[52],"fluid":[53,125],"(CSF)":[54],"collected":[56],"from":[57],"specific":[58],"sites":[59],"within":[60],"cerebroventricular":[62],"system,":[63],"has":[64,94],"provided":[65],"another":[66],"route":[67],"by":[68],"hypothalamic":[70],"activity":[71],"can":[72],"be":[73],"investigated.":[74],"Use":[75],"combination":[80],"with":[81],"other":[82],"methods,":[83],"such":[84,215],"as":[85,178],"intracerebroventricular":[86],"infusion":[87],"simultaneous":[89],"collection,":[93],"yielded":[95],"exciting":[96],"novel":[97],"data":[98],"challenge":[100],"long-held":[101],"dogma":[102],"on":[103],"pathways":[105],"communication":[107,183],"brain.":[110,187],"It":[111],"clear":[113],"CSF":[118,136,159,175],"released":[120],"site-specifically":[121],"and,":[122],"thus,":[123],"not":[127,200],"homogeneous;":[128],"concentration":[130],"factor":[133],"lumbar":[135],"may":[137,176,195],"bear":[138],"no":[139],"relation":[140],"its":[142],"ventricular":[143],"concentration.":[144],"Data":[145],"also":[146],"indicate":[147],"there":[149,167,206],"little,":[151],"if":[152,199],"any,":[153],"transfer":[154],"between":[157],"and":[160],"system.":[164],"In":[165],"addition,":[166],"mounting":[169],"evidence":[170,209],"indicating":[171],"serve":[177],"part":[179],"non-synaptic":[182],"system":[184],"Establishing":[188],"unequivocal":[190],"function":[191],"CSF-borne":[193],"prove":[196],"technically":[197],"difficult,":[198],"impossible.":[201],"we":[203],"believe":[204],"strong":[208],"supporting":[210],"role":[212],"one":[214],"factor,":[216],"GnRH":[217],"CSF,":[219],"sexual":[221],"behaviour.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}