{"id":"https://openalex.org/W79740683","doi":null,"title":"CHARACTERIZING CONSUMPTION, DEPENDENCE, AND THE ROLE OF GLUCOCORTICOIDS IN AN ANIMAL MODEL OF VOLUNTARY ETHANOL CONSUMPTION","display_name":"CHARACTERIZING CONSUMPTION, DEPENDENCE, AND THE ROLE OF GLUCOCORTICOIDS IN AN ANIMAL MODEL OF VOLUNTARY ETHANOL CONSUMPTION","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W79740683","mag":"79740683"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/34","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=psychology_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076674792","display_name":"Lynda J. Sharrett-Field","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lynda Sharrett\u2010Field","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076674792"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00462661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voluntary-ethanol-consumption","display_name":"voluntary ethanol consumption","score":0.796999990940094},{"id":"https://openalex.org/keywords/ethanol-withdrawal","display_name":"ethanol withdrawal","score":0.7879999876022339},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.8169999718666077},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8109999895095825},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/nr2b-subunit","display_name":"NR2B subunit","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.9290000200271606},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.41100001335144043},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7200000286102295},{"id":"https://openalex.org/keywords/animal-models-of-alcoholism","display_name":"animal models of alcoholism","score":0.6039999723434448},{"id":"https://openalex.org/keywords/blood-ethanol","display_name":"blood ethanol","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.6410583853721619},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.6224557161331177},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.5529770255088806},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.5478305220603943},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4929192066192627},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4910457134246826},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.48274868726730347},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.43475186824798584},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43053731322288513},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.42858558893203735},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4235842227935791},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.4214855432510376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39535531401634216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3629668056964874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3423278033733368},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.32995718717575073},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3226841688156128},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3010150194168091},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/34","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},{"id":"mag:79740683","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=psychology_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1033","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/34","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W79740683.pdf","grobid_xml":"https://content.openalex.org/works/W79740683.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W49251522","https://openalex.org/W286924975","https://openalex.org/W1482383190","https://openalex.org/W1545972494","https://openalex.org/W1653173387","https://openalex.org/W1878375548","https://openalex.org/W1895779671","https://openalex.org/W1901422417","https://openalex.org/W1956210563","https://openalex.org/W1964524363","https://openalex.org/W1967256103","https://openalex.org/W1967413223","https://openalex.org/W1973636066","https://openalex.org/W1975731475","https://openalex.org/W1975927238","https://openalex.org/W1977137145","https://openalex.org/W1977546136","https://openalex.org/W1978125276","https://openalex.org/W1979295154","https://openalex.org/W1980077228","https://openalex.org/W1982977141","https://openalex.org/W1983807711","https://openalex.org/W1984305433","https://openalex.org/W1984415186","https://openalex.org/W1984436557","https://openalex.org/W1985454844","https://openalex.org/W1985532399","https://openalex.org/W1990582581","https://openalex.org/W1991728370","https://openalex.org/W1992064811","https://openalex.org/W1994721894","https://openalex.org/W1996208999","https://openalex.org/W2003250723","https://openalex.org/W2007314303","https://openalex.org/W2011293417","https://openalex.org/W2012075671","https://openalex.org/W2012656447","https://openalex.org/W2017871087","https://openalex.org/W2019175367","https://openalex.org/W2021252648","https://openalex.org/W2022183380","https://openalex.org/W2026479627","https://openalex.org/W2037244083","https://openalex.org/W2038705308","https://openalex.org/W2040006431","https://openalex.org/W2041960873","https://openalex.org/W2043159679","https://openalex.org/W2045161094","https://openalex.org/W2045518055","https://openalex.org/W2048414021","https://openalex.org/W2051283142","https://openalex.org/W2056709999","https://openalex.org/W2057884138","https://openalex.org/W2058584151","https://openalex.org/W2058920776","https://openalex.org/W2063892254","https://openalex.org/W2065175940","https://openalex.org/W2066381672","https://openalex.org/W2069410124","https://openalex.org/W2073997424","https://openalex.org/W2074415034","https://openalex.org/W2077387880","https://openalex.org/W2081070804","https://openalex.org/W2081689319","https://openalex.org/W2083443798","https://openalex.org/W2084664557","https://openalex.org/W2087807424","https://openalex.org/W2088112853","https://openalex.org/W2090979638","https://openalex.org/W2095421975","https://openalex.org/W2095882872","https://openalex.org/W2096387598","https://openalex.org/W2096426163","https://openalex.org/W2100193366","https://openalex.org/W2102170600","https://openalex.org/W2106546364","https://openalex.org/W2109477769","https://openalex.org/W2112758820","https://openalex.org/W2114815831","https://openalex.org/W2116173566","https://openalex.org/W2116806046","https://openalex.org/W2118494079","https://openalex.org/W2121113124","https://openalex.org/W2124134368","https://openalex.org/W2133809833","https://openalex.org/W2144768202","https://openalex.org/W2152690383","https://openalex.org/W2157040086","https://openalex.org/W2160579680","https://openalex.org/W2161648669","https://openalex.org/W2163979186","https://openalex.org/W2170017401","https://openalex.org/W2325388645","https://openalex.org/W2408030789","https://openalex.org/W2911771682","https://openalex.org/W2916481247"],"related_works":["https://openalex.org/W2624994890","https://openalex.org/W2074008943","https://openalex.org/W5737588","https://openalex.org/W1977137145","https://openalex.org/W4381384275","https://openalex.org/W2767105672","https://openalex.org/W2038052527","https://openalex.org/W2015207248","https://openalex.org/W2147509050","https://openalex.org/W3003873960"],"abstract_inverted_index":{"Alcohol":[0],"abuse":[1],"disorders":[2,26],"(AUD)":[3],"represent":[4],"a":[5,69,85,153,172,258],"serious":[6],"worldwide":[7],"health":[8],"problem":[9],"with":[10,59,177,184],"far":[11],"reaching":[12],"social,":[13],"financial,":[14],"and":[15,47,49,104,114,121,149,193,204,251,271,277,296,324,352,389,408],"interpersonal":[16],"implications.":[17],"One":[18],"of":[19,24,34,55,76,91,116,127,159,202,220,255,262,274,291,299,320,348,354,365,392],"the":[20,28,53,74,100,111,117,124,157,167,185,194,200,205,253,275,289,297,301,382,403],"most":[21],"devastating":[22],"facets":[23],"these":[25,211],"is":[27,39,171,226,241],"propensity":[29],"to":[30,41,52,82,109,135,190,238,248,266,287,310,314,345,358,370,374,410],"relapse":[31,43,81],"following":[32,208,284,362,386],"periods":[33],"abstinence.":[35],"Ethanol":[36],"withdrawal":[37],"(EWD)":[38],"believed":[40],"promote":[42,180],"by":[44,379],"increasing":[45],"anxiety":[46],"craving,":[48],"may":[50,139,151],"contribute":[51],"development":[54,75,195,254,298],"cognitive":[56,206],"decline":[57],"associated":[58],"long-term":[60],"dependence.":[61],"Clinical":[62],"data":[63,163],"suggest":[64,164],"that":[65,165,229],"stress":[66,92],"also":[67],"plays":[68],"main":[70,173],"role":[71,290],"in":[72,95,99,122,218,257,293,381,396],"both":[73],"AUD":[77],"as":[78,80,182,197,199,377],"well":[79,198],"drinking.":[83],"As":[84,224],"physiological":[86],"stressor,":[87],"EtOH":[88,105,148,222,294,316,326,350,366,371],"elevates":[89],"levels":[90,270,319,327,342,353,361],"hormones":[93],"(cortisol":[94],"humans,":[96],"corticosterone":[97],"(CORT)":[98],"rat).":[101],"Both":[102],"CORT":[103,150,268,292,341,360],"have":[106,132,214],"been":[107,133,188,216],"shown":[108,189],"alter":[110],"composition,":[112],"function,":[113],"activity":[115],"N-methyl-D-aspartate":[118],"(NMDA)":[119],"receptor,":[120,169],"particular,":[123],"NR2B":[125,278,404],"subunit":[126],"this":[128,240],"receptor.":[129],"These":[130,245],"alterations":[131],"suggested":[134],"mediate":[136],"EWD,":[137],"which":[138,170],"negatively":[140],"impact":[141,236],"abstinence":[142],"rates.":[143],"This":[144],"synergistic":[145],"interaction":[146],"between":[147],"present":[152],"therapeutic":[154],"target":[155,174],"for":[156,175],"treatment":[158,183],"EWD.":[160,209],"In":[161],"fact,":[162],"blocking":[166],"glucocorticoid":[168,276,302,406],"CORT,":[176],"RU-486":[178],"could":[179],"abstinence,":[181],"drug":[186],"has":[187],"reduce":[191],"consumption":[192,250,295,321,336,351,355,416],"dependence,":[196,300,376],"severity":[201],"EWD":[203],"deficits":[207],"However,":[210],"latter":[212],"effects":[213],"not":[215,332],"validated":[217],"models":[219],"voluntary":[221,260],"consumption.":[223],"there":[225],"considerable":[227],"evidence":[228],"active":[230],"versus":[231],"passive":[232],"intake":[233],"can":[234],"significantly":[235,333],"neuroadaptations":[237],"ethanol":[239],"an":[242],"important":[243],"consideration.":[244],"studies":[246],"sought":[247],"characterize":[249],"evaluate":[252],"dependence":[256],"chronic":[259],"model":[261],"intermittent":[263],"access":[264,309,313],"(IA)":[265],"EtOH.":[267,311],"plasma":[269],"protein":[272,397],"expression":[273,398],"receptors":[279,407],"were":[280,343,356],"measured":[281,378],"during":[282,308],"and/or":[283],"exposure.":[285,367],"Finally,":[286],"assess":[288],"receptor":[303],"antagonist":[304],"ORG-34517":[305,411],"was":[306,372,399],"administered":[307],"IA":[312,369],"20%":[315],"produced":[317],"varying":[318],"(2.0-6.7g/kg/24hr":[322],"exposure)":[323],"blood":[325],"(6.3-116.9":[328],"mg/dl),":[329],"but":[330],"did":[331],"affect":[334],"food":[335],"or":[337,405,417],"weight":[338],"gain.":[339],"Baseline":[340],"found":[344],"be":[346],"predictive":[347],"subsequent":[349],"sufficient":[357,373],"elevate":[359],"one":[363],"hour":[364],"Further,":[368],"produce":[375],"elevations":[380],"acoustic":[383],"startle":[384],"reflex":[385],"26":[387],"hours":[388],"five":[390],"days":[391],"withdrawal.":[393,418],"No":[394],"alteration":[395],"observed":[400],"regarding":[401],"either":[402],"exposure":[409],"had":[412],"no":[413],"effect":[414],"on":[415]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}